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HUMAN:MYPT1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PPP1R12A (synonyms: MBS, MYPT1)
Protein Name(s) Protein phosphatase 1 regulatory subunit 12A

Myosin phosphatase-targeting subunit 1 Myosin phosphatase target subunit 1 Protein phosphatase myosin-binding subunit

External Links
UniProt O14974
EMBL D87930
AY380574
AF458589
AK302692
AC018476
AC073569
AC074270
BC047898
BC092481
BC111752
AB042196
CCDS CCDS44947.1
CCDS44948.1
CCDS58259.1
CCDS58260.1
RefSeq NP_001137357.1
NP_001137358.1
NP_001231919.1
NP_001231921.1
NP_002471.1
UniGene Hs.49582
PDB 2KJY
PDBsum 2KJY
ProteinModelPortal O14974
SMR O14974
BioGrid 110742
DIP DIP-33186N
IntAct O14974
MINT MINT-195983
STRING 9606.ENSP00000261207
PhosphoSite O14974
OGP O14974
MaxQB O14974
PaxDb O14974
PRIDE O14974
Ensembl ENST00000261207
ENST00000437004
ENST00000450142
ENST00000546369
ENST00000550107
GeneID 4659
KEGG hsa:4659
UCSC uc001syz.3
uc001sza.3
uc001szb.3
uc001szc.2
CTD 4659
GeneCards GC12M080142
H-InvDB HIX0010848
HGNC HGNC:7618
HPA HPA039443
HPA041296
MIM 602021
neXtProt NX_O14974
PharmGKB PA33617
eggNOG COG0666
GeneTree ENSGT00760000119141
HOGENOM HOG000290648
HOVERGEN HBG052561
InParanoid O14974
KO K06270
OMA TDKQTTT
OrthoDB EOG7060Q5
PhylomeDB O14974
TreeFam TF105543
Reactome REACT_160315
ChiTaRS PPP1R12A
EvolutionaryTrace O14974
GeneWiki PPP1R12A
GenomeRNAi 4659
NextBio 17954
PRO PR:O14974
Proteomes UP000005640
Bgee O14974
CleanEx HS_PPP1R12A
ExpressionAtlas O14974
Genevestigator O14974
GO GO:0015629
GO:0005813
GO:0043292
GO:0005737
GO:0005925
GO:0000776
GO:0005654
GO:0072357
GO:0071889
GO:0004857
GO:0019208
GO:0019901
GO:0004871
GO:0051297
GO:0000086
GO:0000278
GO:0007067
GO:0043086
GO:0045944
GO:0006470
GO:0030155
GO:0035507
GO:0046822
GO:0007165
Gene3D 1.25.40.20
InterPro IPR002110
IPR020683
IPR017401
Pfam PF00023
PIRSF PIRSF038141
PRINTS PR01415
SMART SM00248
SUPFAM SSF48403
PROSITE PS50297
PS50088

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0030018

Z disc

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9DBR7

C

Seeded From UniProt

complete

part_of

GO:0031672

A band

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9DBR7

C

Seeded From UniProt

complete

involved_in

GO:0035508

positive regulation of myosin-light-chain-phosphatase activity

PMID:25816133[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:2000008)

Seeded From UniProt

complete

NOT|involved_in

GO:1903140

regulation of establishment of endothelial barrier

PMID:25816133[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

PMID:21423176[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0072357

PTW/PP1 phosphatase complex

PMID:20354225[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0071889

14-3-3 protein binding

PMID:20354225[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007098

centrosome cycle

PMID:18477460[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:19245366[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043292

contractile fiber

PMID:20634291[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043086

negative regulation of catalytic activity

PMID:19245366[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035507

regulation of myosin-light-chain-phosphatase activity

PMID:20354225[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030155

regulation of cell adhesion

PMID:20354225[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:18477460[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P06493

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:18477460[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P53350

F

Seeded From UniProt

complete

enables

GO:0019208

phosphatase regulator activity

PMID:18477460[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019208

phosphatase regulator activity

PMID:20354225[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:18477460[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

PMID:18477460[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:18477460[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004857

enzyme inhibitor activity

PMID:19245366[5]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:18477460[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0035508

positive regulation of myosin-light-chain-phosphatase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000652892
UniProtKB:O14974

P

Seeded From UniProt

complete

part_of

GO:0031672

A band

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1309528
MGI:MGI:1916417
PANTHER:PTN000652891

C

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1309528
MGI:MGI:1916417
PANTHER:PTN000652891

C

Seeded From UniProt

complete

enables

GO:0019208

phosphatase regulator activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001193544
UniProtKB:O14974

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001193544
WB:WBGene00003196

C

Seeded From UniProt

complete

enables

GO:0004857

enzyme inhibitor activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001193544
UniProtKB:O14974

F

Seeded From UniProt

complete

part_of

GO:0015629

actin cytoskeleton

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046822

regulation of nucleocytoplasmic transport

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR7
ensembl:ENSMUSP00000069257

P

Seeded From UniProt

complete

involved_in

GO:0035690

cellular response to drug

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR7
ensembl:ENSMUSP00000069257

P

Seeded From UniProt

complete

part_of

GO:0031672

A band

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR7
ensembl:ENSMUSP00000069257

C

Seeded From UniProt

complete

part_of

GO:0030018

Z disc

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR7
ensembl:ENSMUSP00000069257

C

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9DBR7
ensembl:ENSMUSP00000069257

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017401

P

Seeded From UniProt

complete

enables

GO:0019208

phosphatase regulator activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017401

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031775

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-5671772
Reactome:R-HSA-5668947

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-3002811

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Clark, PR et al. (2015) Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE 10 e0120075 PubMed GONUTS page
  2. ↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Zagórska, A et al. (2010) New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. Sci Signal 3 ra25 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 Yamashiro, S et al. (2008) Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1. Dev. Cell 14 787-97 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Webb, JD et al. (2009) MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH). Biochem. J. 420 327-33 PubMed GONUTS page
  6. ↑ Lontay, B et al. (2010) Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy. J. Biol. Chem. 285 29357-66 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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