GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:MY18A

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MYO18A (synonyms: KIAA0216, MYSPDZ)
Protein Name(s) Unconventional myosin-XVIIIa

Molecule associated with JAK3 N-terminus MAJN Myosin containing a PDZ domain

External Links
UniProt Q92614
EMBL AB177858
AB177860
D86970
CR933614
BC039612
CCDS CCDS45641.1
CCDS45642.1
RefSeq NP_510880.2
NP_976063.1
UniGene Hs.462590
ProteinModelPortal Q92614
SMR Q92614
BioGrid 134384
IntAct Q92614
STRING 9606.ENSP00000346291
PhosphoSite Q92614
DMDM 33301318
MaxQB Q92614
PaxDb Q92614
PRIDE Q92614
Ensembl ENST00000527372
ENST00000531253
ENST00000533112
GeneID 399687
KEGG hsa:399687
UCSC uc002hds.2
uc002hdt.1
uc002hdu.1
uc010csa.1
uc010wbd.1
CTD 399687
GeneCards GC17M027400
HGNC HGNC:31104
HPA HPA019646
HPA021121
MIM 609517
610067
neXtProt NX_Q92614
PharmGKB PA134978348
eggNOG COG5022
GeneTree ENSGT00650000093350
HOGENOM HOG000113701
HOVERGEN HBG052543
InParanoid Q92614
KO K10362
PhylomeDB Q92614
TreeFam TF339614
Reactome REACT_121141
ChiTaRS MYO18A
GeneWiki MYO18A
GenomeRNAi 399687
NextBio 105494
PRO PR:Q92614
Proteomes UP000005640
Bgee Q92614
CleanEx HS_MYO18A
ExpressionAtlas Q92614
Genevestigator Q92614
GO GO:0042641
GO:0005793
GO:0000139
GO:0016020
GO:0016459
GO:0005802
GO:0051015
GO:0043531
GO:0005524
GO:0003677
GO:0003774
GO:0044822
GO:0031032
GO:0016477
GO:0006259
GO:0007030
GO:0048194
GO:0043066
GO:0050714
Gene3D 2.30.42.10
4.10.270.10
InterPro IPR000048
IPR027401
IPR001609
IPR002928
IPR027417
IPR001478
IPR020587
Pfam PF00063
PF01576
PF00595
PRINTS PR00193
SMART SM00015
SM00242
SM00228
SUPFAM SSF50156
SSF52540
PROSITE PS50096
PS51456
PS50106

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051645

Golgi localization

PMID:24485452[1]

ECO:0000315

P

Figure 3c: knockout of MYO18A resulted in decreased dispersion of Golgi bodies.

complete
CACAO 9490

GO:0043066

negative regulation of apoptotic process

PMID:24485452[1]

ECO:0000315

P

figure 7: siRNA knockout of MYO18A results in decreased survival after being subjected to DNA damage, indicating MYO18A participates in a pathway preventing apoptosis.

complete
CACAO 9491

GO:0090161

Golgi ribbon formation

PMID:19837035[2]

ECO:0000315

P

figure 5 - siRNA KO of Myo18A results in condensation of the normal golgi ribbon structure around the nucleus, analogous to figure 3.

complete
CACAO 9522

GO:0090164

asymmetric Golgi ribbon formation

PMID:19837035[2]

ECO:0000315

P

Figure 6- KO of Myo18A results in dilated cisternae of the Golgi Apparatus. It is asymmetrical dilation of the trans-golgi.

complete
CACAO 9523

involved_in

GO:0043030

regulation of macrophage activation

PMID:25965346[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1903028

positive regulation of opsonization

PMID:21123169[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090164

asymmetric Golgi ribbon formation

PMID:19837035[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0090161

Golgi ribbon formation

PMID:19837035[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:24485452[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

PMID:23990465[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0050714

positive regulation of protein secretion

PMID:23345592[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048194

Golgi vesicle budding

PMID:19837035[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[8]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0043531

ADP binding

PMID:23990465[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0042641

actomyosin

PMID:18854160[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031032

actomyosin structure organization

PMID:18854160[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

NOT|enables

GO:0016887

ATPase activity

PMID:23990465[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0016477

cell migration

PMID:18854160[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007030

Golgi organization

PMID:19837035[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005802

trans-Golgi network

PMID:19837035[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:23990465[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048194

C

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020587

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001609
InterPro:IPR004009
InterPro:IPR020587

F

Seeded From UniProt

complete

involved_in

GO:0006259

DNA metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020587

P

Seeded From UniProt

complete

part_of

GO:0016459

myosin complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001609
InterPro:IPR002928
InterPro:IPR004009

C

Seeded From UniProt

complete

enables

GO:0051015

actin filament binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR031244

F

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:9918798[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0333
UniProtKB-SubCell:SL-0132

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016459

myosin complex

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0518

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005793

endoplasmic reticulum-Golgi intermediate compartment

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0098

C

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0310

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Farber-Katz, SE et al. (2014) DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3. Cell 156 413-27 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Dippold, HC et al. (2009) GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Cell 139 337-51 PubMed GONUTS page
  3. ↑ Yang, L et al. (2015) SP-R210 (Myo18A) Isoforms as Intrinsic Modulators of Macrophage Priming and Activation. PLoS ONE 10 e0126576 PubMed GONUTS page
  4. ↑ Sever-Chroneos, Z et al. (2011) Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A. J. Biol. Chem. 286 4854-70 PubMed GONUTS page
  5. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 Taft, MH et al. (2013) Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3. J. Biol. Chem. 288 30029-41 PubMed GONUTS page
  7. ↑ Ng, MM et al. (2013) GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Mol. Biol. Cell 24 796-808 PubMed GONUTS page
  8. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Tan, I et al. (2008) A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow. Cell 135 123-36 PubMed GONUTS page
  10. ↑ Chang, NS et al. (1998) Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity. Biochem. Biophys. Res. Commun. 253 743-9 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:MY18A&oldid=5936003"