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HUMAN:MTNB

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) APIP (ECO:0000255 with HAMAP-Rule:MF_03116)
Protein Name(s) Methylthioribulose-1-phosphate dehydratase (ECO:0000255 with HAMAP-Rule:MF_03116)

MTRu-1-P dehydratase (ECO:0000255 with HAMAP-Rule:MF_03116) APAF1-interacting protein (ECO:0000255 with HAMAP-Rule:MF_03116) hAPIP

External Links
UniProt Q96GX9
EMBL AF132963
AK292648
AC107928
BC008440
BC009077
BC017594
CCDS CCDS7895.1
RefSeq NP_057041.2
UniGene Hs.447794
PDB 4M6R
PDBsum 4M6R
ProteinModelPortal Q96GX9
SMR Q96GX9
BioGrid 119265
IntAct Q96GX9
MINT MINT-1156691
STRING 9606.ENSP00000278359
PhosphoSite Q96GX9
DMDM 74731866
MaxQB Q96GX9
PaxDb Q96GX9
PeptideAtlas Q96GX9
PRIDE Q96GX9
DNASU 51074
Ensembl ENST00000395787
GeneID 51074
KEGG hsa:51074
UCSC uc001mvs.2
CTD 51074
GeneCards GC11M034861
HGNC HGNC:17581
HPA HPA021188
HPA024131
MIM 612491
neXtProt NX_Q96GX9
PharmGKB PA142672601
eggNOG COG0235
GeneTree ENSGT00390000001680
HOGENOM HOG000192424
HOVERGEN HBG080536
InParanoid Q96GX9
KO K08964
OrthoDB EOG74TX0H
PhylomeDB Q96GX9
TreeFam TF105632
Reactome REACT_75881
UniPathway UPA00904
GeneWiki APIP
GenomeRNAi 51074
NextBio 53699
PRO PR:Q96GX9
Proteomes UP000005640
Bgee Q96GX9
CleanEx HS_APIP
ExpressionAtlas Q96GX9
Genevestigator Q96GX9
GO GO:0005829
GO:0042802
GO:0046570
GO:0008270
GO:0006915
GO:0034641
GO:0019509
GO:0019284
GO:0043066
GO:0006595
GO:0070372
GO:0044281
GO:0000096
Gene3D 3.40.225.10
HAMAP MF_03116
InterPro IPR001303
IPR017714
IPR027514
PANTHER PTHR10640
Pfam PF00596
SMART SM01007
SUPFAM SSF53639
TIGRFAMs TIGR03328

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0005737

cytoplasm

PMID:23285211[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0070269

pyroptosis

PMID:24367089[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:24367089[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051289

protein homotetramerization

PMID:24367089[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046570

methylthioribulose 1-phosphate dehydratase activity

PMID:24367089[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

PMID:24367089[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070372

regulation of ERK1 and ERK2 cascade

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9WVQ5

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:22837397[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

PMID:22837397[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

PMID:23285211[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046570

methylthioribulose 1-phosphate dehydratase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067541
SGD:S000003785
UniProtKB:Q96GX9

F

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067541
SGD:S000003785
UniProtKB:Q96GX9

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000067541
UniProtKB:Q96GX9

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96GX9

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19060904[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96GX9

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16189514[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q96GX9

F

Seeded From UniProt

complete

involved_in

GO:0070372

regulation of ERK1 and ERK2 cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVQ5
ensembl:ENSMUSP00000011055

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9WVQ5
ensembl:ENSMUSP00000011055

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017714
InterPro:IPR027514

C

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017714
InterPro:IPR027514

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017714
InterPro:IPR027514

F

Seeded From UniProt

complete

enables

GO:0046570

methylthioribulose 1-phosphate dehydratase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:4.2.1.109

F

Seeded From UniProt

complete

enables

GO:0008270

zinc ion binding

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000106743

F

Seeded From UniProt

complete

involved_in

GO:0019284

L-methionine salvage from S-adenosylmethionine

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000106743

P

Seeded From UniProt

complete

enables

GO:0046570

methylthioribulose 1-phosphate dehydratase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000106743

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6804596

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

involved_in

GO:0009086

methionine biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0486

P

Seeded From UniProt

complete

enables

GO:0016829

lyase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0456

F

Seeded From UniProt

complete

involved_in

GO:0008652

cellular amino acid biosynthetic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0028

P

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00904

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Mary, C et al. (2012) Functional identification of APIP as human mtnB, a key enzyme in the methionine salvage pathway. PLoS ONE 7 e52877 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Kang, W et al. (2014) Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc. Natl. Acad. Sci. U.S.A. 111 E54-61 PubMed GONUTS page
  3. ↑ 3.0 3.1 Ko, DC et al. (2012) Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. Proc. Natl. Acad. Sci. U.S.A. 109 E2343-52 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  6. ↑ Venkatesan, K et al. (2009) An empirical framework for binary interactome mapping. Nat. Methods 6 83-90 PubMed GONUTS page
  7. ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
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