GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

HUMAN:MTAP

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MTAP (ECO:0000255 with HAMAP-Rule:MF_03155) (synonyms: MSAP)
Protein Name(s) S-methyl-5'-thioadenosine phosphorylase (ECO:0000255 with HAMAP-Rule:MF_03155)

5'-methylthioadenosine phosphorylase (ECO:0000255 with HAMAP-Rule:MF_03155) MTA phosphorylase (ECO:0000255 with HAMAP-Rule:MF_03155) MTAP (ECO:0000255 with HAMAP-Rule:MF_03155) MTAPase (ECO:0000255 with HAMAP-Rule:MF_03155)

External Links
UniProt Q13126
EMBL U22233
L40432
L42634
L42627
L42628
L42629
L42630
L42631
L42632
L42633
HE654772
HE654773
HE654774
HE654775
HE654776
HE654777
AY712791
AL359922
CH471071
BC026106
CCDS CCDS6509.1
PIR I38969
RefSeq NP_002442.2
UniGene Hs.193268
PDB 1CB0
1CG6
1K27
1SD1
1SD2
3LN5
3OZC
3OZD
3OZE
PDBsum 1CB0
1CG6
1K27
1SD1
1SD2
3LN5
3OZC
3OZD
3OZE
ProteinModelPortal Q13126
SMR Q13126
BioGrid 110611
IntAct Q13126
MINT MINT-268764
STRING 9606.ENSP00000369519
BindingDB Q13126
ChEMBL CHEMBL4941
DrugBank DB00173
PhosphoSite Q13126
DMDM 143811423
REPRODUCTION-2DPAGE Q13126
UCD-2DPAGE Q13126
MaxQB Q13126
PaxDb Q13126
PRIDE Q13126
DNASU 4507
Ensembl ENST00000380172
ENST00000580900
GeneID 4507
KEGG hsa:4507
UCSC uc003zph.3
uc031tcz.1
uc031tda.1
uc031tdb.1
uc031tdc.1
uc031tdd.1
uc031tde.1
CTD 4507
GeneCards GC09P021792
H-InvDB HIX0007954
HIX0025895
HGNC HGNC:7413
HPA HPA046915
MIM 112250
156540
neXtProt NX_Q13126
Orphanet 85182
PharmGKB PA31220
eggNOG COG0005
GeneTree ENSGT00550000074874
HOGENOM HOG000228986
HOVERGEN HBG002487
KO K00772
OrthoDB EOG771270
PhylomeDB Q13126
TreeFam TF312883
BioCyc MetaCyc:HS01913-MONOMER
Reactome REACT_75881
SABIO-RK Q13126
SignaLink Q13126
UniPathway UPA00904
ChiTaRS MTAP
EvolutionaryTrace Q13126
GeneWiki MTAP
GenomeRNAi 4507
NextBio 17416
PRO PR:Q13126
Proteomes UP000005640
Bgee Q13126
CleanEx HS_MTAP
ExpressionAtlas Q13126
Genevestigator Q13126
GO GO:0005737
GO:0005829
GO:0070062
GO:0005634
GO:0004645
GO:0017061
GO:0034641
GO:0019509
GO:0006139
GO:0006595
GO:0006166
GO:0044281
GO:0000096
Gene3D 3.40.50.1580
HAMAP MF_01963
InterPro IPR010044
IPR000845
IPR001369
IPR018099
PANTHER PTHR11904
Pfam PF01048
SUPFAM SSF53167
TIGRFAMs TIGR01694
PROSITE PS01240

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0070062

extracellular exosome

PMID:19056867[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

NOT|involved_in

GO:0006738

nicotinamide riboside catabolic process

PMID:19001417[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000224684
SGD:S000004007

P

Seeded From UniProt

complete

enables

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000224684
RGD:1310114
SGD:S000004007

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000224684
UniProtKB:Q13126

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000224684
SGD:S000004007

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0033574

response to testosterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TP15
ensembl:ENSRNOP00000031214

P

Seeded From UniProt

complete

enables

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TP15
ensembl:ENSRNOP00000031214

F

Seeded From UniProt

complete

involved_in

GO:0032259

methylation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9CQ65
ensembl:ENSMUSP00000061092

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000845
InterPro:IPR035994

F

Seeded From UniProt

complete

involved_in

GO:0009116

nucleoside metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000845
InterPro:IPR035994

P

Seeded From UniProt

complete

enables

GO:0016763

transferase activity, transferring pentosyl groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR018099

F

Seeded From UniProt

complete

enables

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR010044

F

Seeded From UniProt

complete

enables

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.4.2.28

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000337064

C

Seeded From UniProt

complete

enables

GO:0017061

S-methyl-5-thioadenosine phosphorylase activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000337064

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000337064

C

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000337064

P

Seeded From UniProt

complete

involved_in

GO:0006139

nucleobase-containing compound metabolic process

PMID:8687427[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004645

phosphorylase activity

PMID:8687427[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035722

interleukin-12-mediated signaling pathway

Reactome:R-HSA-9020591

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

Reactome:R-HSA-1237112

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8950365
Reactome:R-HSA-1237160

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0016757

transferase activity, transferring glycosyl groups

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0328

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006166

purine ribonucleoside salvage

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0660

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0019509

L-methionine salvage from methylthioadenosine

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00904

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  2. ↑ Belenky, P et al. (2009) Nicotinamide riboside and nicotinic acid riboside salvage in fungi and mammals. Quantitative basis for Urh1 and purine nucleoside phosphorylase function in NAD+ metabolism. J. Biol. Chem. 284 158-64 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Della Ragione, F et al. (1996) Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA. Biochem. Biophys. Res. Commun. 223 514-9 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=HUMAN:MTAP&oldid=5956321"