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HUMAN:MT21A
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | METTL21A (synonyms: FAM119A, HCA557B) | |
| Protein Name(s) | Protein N-lysine methyltransferase METTL21A
HSPA lysine methyltransferase HSPA-KMT Hepatocellular carcinoma-associated antigen 557b Methyltransferase-like protein 21A | |
| External Links | ||
| UniProt | Q8WXB1 | |
| EMBL | AF455817 AK093812 AC079767 BC009462 BC033720 | |
| CCDS | CCDS2376.1 | |
| RefSeq | NP_001120867.1 NP_660323.3 XP_005246396.1 XP_005246397.1 XP_005246398.1 XP_006712392.1 | |
| UniGene | Hs.664764 | |
| PDB | 4LEC | |
| PDBsum | 4LEC | |
| ProteinModelPortal | Q8WXB1 | |
| SMR | Q8WXB1 | |
| BioGrid | 127352 | |
| IntAct | Q8WXB1 | |
| STRING | 9606.ENSP00000385481 | |
| PhosphoSite | Q8WXB1 | |
| DMDM | 150382834 | |
| MaxQB | Q8WXB1 | |
| PaxDb | Q8WXB1 | |
| PRIDE | Q8WXB1 | |
| DNASU | 151194 | |
| Ensembl | ENST00000406927 ENST00000411432 ENST00000425132 ENST00000426075 ENST00000442521 ENST00000448007 ENST00000458426 | |
| GeneID | 151194 | |
| KEGG | hsa:151194 | |
| UCSC | uc002vce.3 uc002vcf.2 | |
| CTD | 151194 | |
| GeneCards | GC02M208446 | |
| HGNC | HGNC:30476 | |
| HPA | HPA034712 | |
| MIM | 615257 | |
| neXtProt | NX_Q8WXB1 | |
| PharmGKB | PA145008433 | |
| eggNOG | COG0500 | |
| GeneTree | ENSGT00550000074572 | |
| HOVERGEN | HBG059353 | |
| InParanoid | Q8WXB1 | |
| PhylomeDB | Q8WXB1 | |
| TreeFam | TF313206 | |
| ChiTaRS | METTL21A | |
| GenomeRNAi | 151194 | |
| NextBio | 86616 | |
| PRO | PR:Q8WXB1 | |
| Proteomes | UP000005640 | |
| Bgee | Q8WXB1 | |
| CleanEx | HS_FAM119A | |
| ExpressionAtlas | Q8WXB1 | |
| Genevestigator | Q8WXB1 | |
| GO | GO:0005737 GO:0051117 GO:0030544 GO:0016279 GO:0018022 GO:0006479 | |
| Gene3D | 3.40.50.150 | |
| InterPro | IPR019410 IPR029063 | |
| Pfam | PF10294 | |
| SUPFAM | SSF53335 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016279 |
protein-lysine N-methyltransferase activity |
ECO:0000314 |
F |
Figure 2C |
complete | |||||
|
enables |
GO:0008276 |
protein methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006479 |
protein methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016279 |
protein-lysine N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0051117 |
ATPase binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0043462 |
regulation of ATPase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018022 |
peptidyl-lysine methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_direct_input:(UniProtKB:P11142)|has_direct_input:(UniProtKB:P0DMV8)|has_direct_input:(UniProtKB:P11021)|has_direct_input:(UniProtKB:P54652)|has_direct_input:(UniProtKB:P17066)|has_direct_input:(UniProtKB:P0DMV9) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016279 |
protein-lysine N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
has_direct_input:(UniProtKB:P11142)|has_direct_input:(UniProtKB:P0DMV9)|has_direct_input:(UniProtKB:P11021)|has_direct_input:(UniProtKB:P54652)|has_direct_input:(UniProtKB:P17066)|has_direct_input:(UniProtKB:P0DMV8) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016279 |
protein-lysine N-methyltransferase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006479 |
protein methylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016279 |
protein-lysine N-methyltransferase activity |
Reactome:R-HSA-8932221 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006479 |
protein methylation |
Reactome:R-HSA-8876725 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005654 |
nucleoplasm |
Reactome:R-HSA-8932221 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032259 |
methylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008168 |
methyltransferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 1.12 Jakobsson, ME et al. (2013) Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J. Biol. Chem. 288 27752-63 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Cloutier, P et al. (2013) A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. PLoS Genet. 9 e1003210 PubMed GONUTS page
- ↑ 3.0 3.1 Kernstock, S et al. (2012) Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Nat Commun 3 1038 PubMed GONUTS page
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