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HUMAN:MSI1H

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MSI1
Protein Name(s) RNA-binding protein Musashi homolog 1

Musashi-1

External Links
UniProt O43347
EMBL AB012851
AC003982
AB072590
AB072591
AB072592
AB073212
CCDS CCDS9196.1
RefSeq NP_002433.1
UniGene Hs.158311
ProteinModelPortal O43347
SMR O43347
BioGrid 110577
IntAct O43347
MINT MINT-1432501
STRING 9606.ENSP00000257552
PhosphoSite O43347
MaxQB O43347
PaxDb O43347
PRIDE O43347
DNASU 4440
Ensembl ENST00000257552
GeneID 4440
KEGG hsa:4440
UCSC uc001tye.2
CTD 4440
GeneCards GC12M120779
HGNC HGNC:7330
HPA CAB022337
MIM 603328
neXtProt NX_O43347
PharmGKB PA31137
eggNOG COG0724
GeneTree ENSGT00730000110584
HOGENOM HOG000234441
HOVERGEN HBG002295
InParanoid O43347
KO K14411
OMA METDAPQ
OrthoDB EOG715Q6V
PhylomeDB O43347
TreeFam TF325419
GeneWiki MSI1
GenomeRNAi 4440
NextBio 17313
PRO PR:O43347
Proteomes UP000005640
Bgee O43347
CleanEx HS_MSI1
ExpressionAtlas O43347
Genevestigator O43347
GO GO:0005737
GO:0005634
GO:0005844
GO:0000166
GO:0044822
GO:0008266
GO:0003723
GO:0030855
GO:0007399
GO:0009725
Gene3D 3.30.70.330
InterPro IPR012677
IPR000504
Pfam PF00076
SMART SM00360
PROSITE PS50102

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

PMID:22428049[1]

ECO:0000314

P

Figure 4

complete
CACAO 4756

enables

GO:0003723

RNA binding

PMID:22681889[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:1990904

ribonucleoprotein complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001215
FB:FBgn0004237
FB:FBgn0004838
MGI:MGI:1916394
PANTHER:PTN002689974
UniProtKB:P09651
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:Q14103
UniProtKB:Q96EP5
UniProtKB:Q99729

C

Seeded From UniProt

complete

part_of

GO:0005844

polysome

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107376
MGI:MGI:1923876
PANTHER:PTN002690062

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:107376
MGI:MGI:1923876
PANTHER:PTN002690062
WB:WBGene00003423

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:104819
MGI:MGI:1330294
MGI:MGI:893588
MGI:MGI:97286
PANTHER:PTN002689974
RGD:1306751
RGD:1310403
RGD:1310906
RGD:3153
RGD:69234
SGD:S000003391
SGD:S000005483
TAIR:locus:2019622
TAIR:locus:2076096
TAIR:locus:2079874
TAIR:locus:2083810
TAIR:locus:2122009
TAIR:locus:2159401
TAIR:locus:2179939
UniProtKB:P19338
UniProtKB:P22626
UniProtKB:P38159
UniProtKB:P62995
UniProtKB:Q03250
UniProtKB:Q13148
UniProtKB:Q14103
UniProtKB:Q9SVM8

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

F

Seeded From UniProt

complete

enables

GO:0008266

poly(U) RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

F

Seeded From UniProt

complete

part_of

GO:0005844

polysome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

C

Seeded From UniProt

complete

enables

GO:0003727

single-stranded RNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61474
ensembl:ENSMUSP00000120516

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000504
InterPro:IPR035979

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR034126
InterPro:IPR034130

F

Seeded From UniProt

complete

involved_in

GO:0007399

nervous system development

PMID:9790759[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:9790759[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Muto, J et al. (2012) RNA-binding protein Musashi1 modulates glioma cell growth through the post-transcriptional regulation of Notch and PI3 kinase/Akt signaling pathways. PLoS ONE 7 e33431 PubMed GONUTS page
  2. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 Good, P et al. (1998) The human Musashi homolog 1 (MSI1) gene encoding the homologue of Musashi/Nrp-1, a neural RNA-binding protein putatively expressed in CNS stem cells and neural progenitor cells. Genomics 52 382-4 PubMed GONUTS page