HUMAN:MRP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	ABCC1 (synonyms: MRP, MRP1)
Protein Name(s)	Multidrug resistance-associated protein 1 ATP-binding cassette sub-family C member 1 Leukotriene C(4) transporter LTC4 transporter
External Links
UniProt	P33527
EMBL	L05628 AF022853 AF022827 AF022828 AF022829 AF022831 AF022833 AF022835 AF022837 AF022839 AF022841 AF022850 AF022849 AF022848 AF022847 AF022846 AF022845 AF022844 AF022843 AF022842 AF022852 AF022851 AF022840 AF022838 AF022836 AF022834 AF022832 AF022826 AF022825 AF022824 AF022830 AF022853 AF022824 AF022825 AF022826 AF022828 AF022830 AF022832 AF022834 AF022836 AF022838 AF022848 AF022847 AF022846 AF022845 AF022844 AF022843 AF022842 AF022841 AF022839 AF022852 AF022851 AF022850 AF022849 AF022837 AF022835 AF022833 AF022831 AF022829 AF022827 AF022853 AF022824 AF022825 AF022826 AF022827 AF022829 AF022831 AF022833 AF022835 AF022837 AF022847 AF022846 AF022845 AF022844 AF022843 AF022842 AF022841 AF022840 AF022838 AF022852 AF022851 AF022850 AF022849 AF022848 AF022836 AF022834 AF022832 AF022830 AF022828 AF022853 AF022824 AF022825 AF022826 AF022827 AF022828 AF022829 AF022830 AF022831 AF022832 AF022833 AF022834 AF022835 AF022836 AF022837 AF022838 AF022839 AF022840 AF022841 AF022842 AF022843 AF022844 AF022845 AF022846 AF022847 AF022848 AF022849 AF022850 AF022851 EF419769 AC025778 AC130651 AC136624 AB209120 U91318 AC003026
CCDS	CCDS42122.1
PIR	A44231
RefSeq	NP_004987.2 XP_005255386.1 XP_006720947.1
UniGene	Hs.391464
PDB	2CBZ 4C3Z
PDBsum	2CBZ 4C3Z
ProteinModelPortal	P33527
SMR	P33527
BioGrid	110503
IntAct	P33527
MINT	MINT-2802626
BindingDB	P33527
ChEMBL	CHEMBL3004
DrugBank	DB05812 DB00345 DB00701 DB01072 DB01076 DB01394 DB00286 DB00091 DB00970 DB00694 DB00586 DB01248 DB00997 DB00445 DB00199 DB00773 DB00693 DB00143 DB01016 DB01050 DB01177 DB00224 DB00328 DB00762 DB00602 DB00709 DB00563 DB00834 DB01204 DB01165 DB01229 DB01174 DB01032 DB00396 DB01045 DB00503 DB01098 DB01232 DB06335 DB01138 DB05294 DB08881 DB00661 DB00570 DB00541 DB00399
TCDB	3.A.1.208.8
PhosphoSite	P33527
DMDM	296439301
MaxQB	P33527
PaxDb	P33527
PRIDE	P33527
Ensembl	ENST00000399410 ENST00000621144
GeneID	4363
KEGG	hsa:4363
UCSC	uc010bvi.3
CTD	4363
GeneCards	GC16P016043
H-InvDB	HIX0134370
HGNC	HGNC:51
HPA	CAB016097 HPA002380
MIM	158343
neXtProt	NX_P33527
PharmGKB	PA244
eggNOG	COG1132
GeneTree	ENSGT00770000120479
HOVERGEN	HBG108314
InParanoid	P33527
KO	K05665
OMA	DISRHHN
OrthoDB	EOG7MWGW0
PhylomeDB	P33527
TreeFam	TF105199
Reactome	REACT_150420 REACT_15480 REACT_163862
ChiTaRS	ABCC1
EvolutionaryTrace	P33527
GeneWiki	ABCC1
GenomeRNAi	4363
NextBio	17171
PRO	PR:P33527
Proteomes	UP000005640 UP000005640
Bgee	P33527
CleanEx	HS_ABCC1
ExpressionAtlas	P33527
Genevestigator	P33527
GO	GO:0070062 GO:0005887 GO:0016020 GO:0005886 GO:0005524 GO:0016887 GO:0042626 GO:0005215 GO:0019369 GO:0006200 GO:0009235 GO:0006691 GO:0042493 GO:0044281 GO:0055085 GO:0006810 GO:0006766 GO:0006767
Gene3D	3.40.50.300
InterPro	IPR003593 IPR011527 IPR003439 IPR017871 IPR030241 IPR005292 IPR027417
PANTHER	PTHR24223:SF203
Pfam	PF00664 PF00005
SMART	SM00382
SUPFAM	SSF52540 SSF90123
TIGRFAMs	TIGR00957
PROSITE	PS50929 PS00211 PS50893

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016323	basolateral plasma membrane	PMID:24130369^[1]	ECO:0000314			C		Figure 1	complete CACAO 9062
involved_in	GO:0060326	cell chemotaxis	PMID:17050692^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8CG09	P		Seeded From UniProt	complete
enables	GO:0046623	sphingolipid-translocating ATPase activity	PMID:17050692^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	transports_or_maintains_localization_of:(CHEBI:37550)	Seeded From UniProt	complete
involved_in	GO:0099039	sphingolipid translocation	PMID:17050692^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(CHEBI:37550)	Seeded From UniProt	complete
enables	GO:0004012	phospholipid-translocating ATPase activity	PMID:17050692^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	transports_or_maintains_localization_of:(CHEBI:37550)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17050692^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045332	phospholipid translocation	PMID:17050692^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	transports_or_maintains_localization_of:(CHEBI:37550)	Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:24130369^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	PMID:15999530^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:3112 SGD:S000002542 TAIR:locus:2061559 UniProtKB:A7KVC2 UniProtKB:Q10RX7	P		Seeded From UniProt	complete
involved_in	GO:0042908	xenobiotic transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000657997 RGD:71101 TAIR:locus:2061559 UniProtKB:Q9LK64	F		Seeded From UniProt	complete
involved_in	GO:0034775	glutathione transmembrane transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658336 RGD:3112	P		Seeded From UniProt	complete
enables	GO:0034634	glutathione transmembrane transporter activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658336 RGD:3112	F		Seeded From UniProt	complete
part_of	GO:0016323	basolateral plasma membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658318 RGD:3112 UniProtKB:P33527	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1352447 PANTHER:PTN000657997 RGD:2366 RGD:3112 RGD:620268 UniProtKB:O15439 UniProtKB:O15440	C		Seeded From UniProt	complete
enables	GO:0008559	xenobiotic transmembrane transporting ATPase activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	F		Seeded From UniProt	complete
involved_in	GO:0006855	drug transmembrane transport	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000658334 RGD:3112	P		Seeded From UniProt	complete
part_of	GO:0005774	vacuolar membrane	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001954664 TAIR:locus:2043268 TAIR:locus:2061559 TAIR:locus:2077750 TAIR:locus:2081755 TAIR:locus:2090039 TAIR:locus:2090049 TAIR:locus:2094721 TAIR:locus:2204202 UniProtKB:Q7GB25 UniProtKB:Q9LK64	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0015889	cobalamin transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015420	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35379 ensembl:ENSMUSP00000097743	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR011527 InterPro:IPR017871 InterPro:IPR036640	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292 InterPro:IPR011527 InterPro:IPR036640	C		Seeded From UniProt	complete
enables	GO:0016887	ATPase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003439 InterPro:IPR017871	F		Seeded From UniProt	complete
enables	GO:0022857	transmembrane transporter activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292	F		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011527	F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR005292 InterPro:IPR011527	P		Seeded From UniProt	complete
enables	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	PMID:1360704^[7] Reactome:R-HSA-266070	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:1360704^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:1360704^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1360704^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:1360704^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005215	transporter activity	PMID:1360704^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	Reactome:R-HSA-382556	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0015420	cobalamin-transporting ATPase activity	Reactome:R-HSA-3095901	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009235	cobalamin metabolic process	Reactome:R-HSA-196741	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006691	leukotriene metabolic process	Reactome:R-HSA-2142691	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-3095901 Reactome:R-HSA-266070 Reactome:R-HSA-1454916	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mitra, P et al. (2006) Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. U.S.A. 103 16394-9 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ Beljanski, V et al. () Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo 19 657-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cole, SP et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258 1650-4 PubMed GONUTS page

[PMID:24130369-1] 1.0 ^1.1 Klein, DM et al. (2014) Localization of multidrug resistance-associated proteins along the blood-testis barrier in rat, macaque, and human testis. Drug Metab. Dispos. 42 89-93 PubMed GONUTS page

[PMID:17050692-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Mitra, P et al. (2006) Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. Proc. Natl. Acad. Sci. U.S.A. 103 16394-9 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:20458337-4] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:15999530-5] Beljanski, V et al. () Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2). In Vivo 19 657-60 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 ^6.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1360704-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Cole, SP et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258 1650-4 PubMed GONUTS page

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HUMAN:MRP1

Contents

Annotations

Notes

References

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