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HUMAN:MPIP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) CDC25A
Protein Name(s) M-phase inducer phosphatase 1

Dual specificity phosphatase Cdc25A

External Links
UniProt P30304
EMBL M81933
AY137580
AF527417
BC007401
BC018642
AF277722
CCDS CCDS2760.1
CCDS2761.1
PIR A41648
RefSeq NP_001780.2
NP_963861.1
UniGene Hs.437705
PDB 1C25
PDBsum 1C25
ProteinModelPortal P30304
SMR P30304
BioGrid 107428
DIP DIP-166N
IntAct P30304
MINT MINT-124723
STRING 9606.ENSP00000303706
BindingDB P30304
ChEMBL CHEMBL3775
DEPOD P30304
PhosphoSite P30304
DMDM 50403734
MaxQB P30304
PaxDb P30304
PRIDE P30304
DNASU 993
Ensembl ENST00000302506
ENST00000351231
GeneID 993
KEGG hsa:993
UCSC uc003csh.1
uc003csi.1
CTD 993
GeneCards GC03M048173
HGNC HGNC:1725
HPA HPA005855
MIM 116947
neXtProt NX_P30304
PharmGKB PA26259
eggNOG COG5105
GeneTree ENSGT00390000018747
HOGENOM HOG000082672
HOVERGEN HBG052501
InParanoid P30304
KO K06645
OMA NLTVTMD
OrthoDB EOG7288R1
PhylomeDB P30304
TreeFam TF101056
BRENDA 3.1.3.48
Reactome REACT_1006
REACT_111214
REACT_1321
REACT_1614
REACT_1857
REACT_2101
REACT_2160
REACT_471
REACT_6769
REACT_683
REACT_9029
ChiTaRS CDC25A
EvolutionaryTrace P30304
GeneWiki CDC25A
GenomeRNAi 993
NextBio 4164
PRO PR:P30304
Proteomes UP000005640
Bgee P30304
CleanEx HS_CDC25A
ExpressionAtlas P30304
Genevestigator P30304
GO GO:0005829
GO:0005654
GO:0019901
GO:0004725
GO:0008283
GO:0034644
GO:0006260
GO:0000082
GO:0000086
GO:0000278
GO:0007067
GO:0051726
GO:0000079
GO:0009314
Gene3D 3.40.250.10
InterPro IPR000751
IPR001763
Pfam PF06617
PF00581
PRINTS PR00716
SMART SM00450
SUPFAM SSF52821
PROSITE PS50206

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0051087

chaperone binding

PMID:22843495[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P07900
UniProtKB:P08238

F

Seeded From UniProt

complete

involved_in

GO:0034644

cellular response to UV

PMID:19966869[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21376736[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q9H4B4

F

Seeded From UniProt

complete

involved_in

GO:0009314

response to radiation

PMID:21376736[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0110032

positive regulation of G2/MI transition of meiotic cell cycle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000089071
PomBase:SPAC24H6.05

P

Seeded From UniProt

complete

involved_in

GO:0045931

positive regulation of mitotic cell cycle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003525
PANTHER:PTN000089071
UniProtKB:P30305

P

Seeded From UniProt

complete

involved_in

GO:0010971

positive regulation of G2/M transition of mitotic cell cycle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000089071
PomBase:SPAC24H6.05

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:103198
MGI:MGI:88350
MGI:MGI:99701
PANTHER:PTN000850864
PomBase:SPAC24H6.05
RGD:621498

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0002673
FB:FBgn0003525
MGI:MGI:103198
MGI:MGI:88350
MGI:MGI:99701
PANTHER:PTN000850864
PomBase:SPAC24H6.05
RGD:1311875
RGD:621498
UniProtKB:P30307
WB:WBGene00000386
WB:WBGene00000388

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003525
PANTHER:PTN000850864
PomBase:SPAC24H6.05
TAIR:locus:505006579
UniProtKB:P30303

F

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003525
PANTHER:PTN000089071
SGD:S000004639
UniProtKB:P30303
UniProtKB:P30307

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

involved_in

GO:0035335

peptidyl-tyrosine dephosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004725

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48964
ensembl:ENSMUSP00000091882

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P48964
ensembl:ENSMUSP00000091882

C

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000751

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000751

P

Seeded From UniProt

complete

involved_in

GO:1902751

positive regulation of cell cycle G2/M phase transition

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000751

P

Seeded From UniProt

complete

enables

GO:0004725

protein tyrosine phosphatase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.3.48

F

Seeded From UniProt

complete

involved_in

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:7667636[5]
PMID:11139144[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0008283

cell population proliferation

PMID:11139144[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

Reactome:R-HSA-156711

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016579

protein deubiquitination

Reactome:R-HSA-5688426

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-69600
Reactome:R-HSA-69598
Reactome:R-HSA-5696600
Reactome:R-HSA-170159

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8863014
Reactome:R-HSA-69608
Reactome:R-HSA-69604
Reactome:R-HSA-69199
Reactome:R-HSA-4088152
Reactome:R-HSA-188345
Reactome:R-HSA-174110
Reactome:R-HSA-170159
Reactome:R-HSA-170158
Reactome:R-HSA-170153

ECO:0000304

author statement supported by traceable reference used in manual assertion










C

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

Reactome:R-HSA-69199
Reactome:R-HSA-170158

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

involved_in

GO:0000086

G2/M transition of mitotic cell cycle

Reactome:R-HSA-69275

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

Reactome:R-HSA-69206

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004721

phosphoprotein phosphatase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0904

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ Giessrigl, B et al. (2012) Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. Hum. Mol. Genet. 21 4615-27 PubMed GONUTS page
  2. ↑ Peschiaroli, A et al. (2010) The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene 29 1384-93 PubMed GONUTS page
  3. ↑ 3.0 3.1 Myer, DL et al. (2011) Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors. Mutat. Res. 714 1-10 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Galaktionov, K et al. (1995) CDC25 phosphatases as potential human oncogenes. Science 269 1575-7 PubMed GONUTS page
  6. ↑ 6.0 6.1 Wegener, S et al. (2000) Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. Eur. J. Cell Biol. 79 810-5 PubMed GONUTS page
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