GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
HUMAN:MMP15
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MMP15 | |
| Protein Name(s) | Matrix metalloproteinase-15
MMP-15 Membrane-type matrix metalloproteinase 2 MT-MMP 2 MTMMP2 Membrane-type-2 matrix metalloproteinase MT2-MMP MT2MMP SMCP-2 | |
| External Links | ||
| UniProt | P51511 | |
| EMBL | Z48482 EF032329 BC036495 BC055428 D86331 D85510 | |
| CCDS | CCDS10792.1 | |
| PIR | I38029 | |
| RefSeq | NP_002419.1 | |
| UniGene | Hs.80343 | |
| ProteinModelPortal | P51511 | |
| SMR | P51511 | |
| BioGrid | 110467 | |
| IntAct | P51511 | |
| MINT | MINT-7897770 | |
| STRING | 9606.ENSP00000219271 | |
| BindingDB | P51511 | |
| ChEMBL | CHEMBL2963 | |
| DrugBank | DB00786 | |
| GuidetoPHARMACOLOGY | 1639 | |
| MEROPS | M10.015 | |
| iPTMnet | P51511 | |
| PhosphoSite | P51511 | |
| BioMuta | MMP15 | |
| DMDM | 1705988 | |
| MaxQB | P51511 | |
| PaxDb | P51511 | |
| PRIDE | P51511 | |
| DNASU | 4324 | |
| Ensembl | ENST00000219271 | |
| GeneID | 4324 | |
| KEGG | hsa:4324 | |
| UCSC | uc002ena.4 | |
| CTD | 4324 | |
| GeneCards | MMP15 | |
| HGNC | HGNC:7161 | |
| HPA | CAB002611 HPA040390 | |
| MIM | 602261 | |
| neXtProt | NX_P51511 | |
| PharmGKB | PA30873 | |
| eggNOG | KOG1565 ENOG410XQ5D | |
| GeneTree | ENSGT00760000118870 | |
| HOGENOM | HOG000217928 | |
| HOVERGEN | HBG052484 | |
| InParanoid | P51511 | |
| KO | K07995 | |
| OMA | CVLGLTY | |
| OrthoDB | EOG7XPZ57 | |
| PhylomeDB | P51511 | |
| TreeFam | TF352396 | |
| BRENDA | 3.4.24.B5 | |
| Reactome | R-HSA-1442490 R-HSA-1474228 R-HSA-1592389 | |
| GeneWiki | MMP15 | |
| GenomeRNAi | 4324 | |
| NextBio | 17013 | |
| PRO | PR:P51511 | |
| Proteomes | UP000005640 | |
| Bgee | P51511 | |
| CleanEx | HS_MMP15 | |
| ExpressionAtlas | P51511 | |
| Genevisible | P51511 | |
| GO | GO:0031012 GO:0005887 GO:0005886 GO:0005509 GO:0008047 GO:0004222 GO:0008270 GO:0006464 GO:0030574 GO:0035987 GO:0022617 GO:0030198 GO:0043085 GO:0032355 | |
| Gene3D | 2.110.10.10 3.40.390.10 | |
| InterPro | IPR000585 IPR018487 IPR018486 IPR024079 IPR028729 IPR001818 IPR021190 IPR021805 IPR016293 IPR021158 IPR006026 IPR002477 | |
| PANTHER | PTHR10201:SF25 | |
| Pfam | PF11857 PF00045 PF00413 PF01471 | |
| PIRSF | PIRSF001191 | |
| PRINTS | PR00138 | |
| SMART | SM00120 SM00235 | |
| SUPFAM | SSF47090 SSF50923 | |
| PROSITE | PS00546 PS00024 PS51642 PS00142 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0035987 |
endodermal cell differentiation |
ECO:0000270 |
expression pattern evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030574 |
collagen catabolic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101900 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030198 |
extracellular matrix organization |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:97005 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0033438 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043085 |
positive regulation of catalytic activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008047 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032355 |
response to estradiol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZCG5 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR001818 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0070006 |
metalloaminopeptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
has_input:(UniProtKB:Q07954) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
has_input:(UniProtKB:Q07954) |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008047 |
enzyme activator activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006464 |
cellular protein modification process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004222 |
metalloendopeptidase activity |
PMID:7649159[4] |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0030574 |
collagen catabolic process |
Reactome:R-HSA-1442490 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
Reactome:R-HSA-1474228 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-NUL-2533964 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008237 |
metallopeptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Brafman, DA et al. (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ. 20 369-81 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 Rozanov, DV et al. (2004) The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells. J. Biol. Chem. 279 4260-8 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 Will, H & Hinzmann, B (1995) cDNA sequence and mRNA tissue distribution of a novel human matrix metalloproteinase with a potential transmembrane segment. Eur. J. Biochem. 231 602-8 PubMed GONUTS page
- ↑ 5.0 5.1 Takino, T et al. (1995) Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. J. Biol. Chem. 270 23013-20 PubMed GONUTS page
c
e
m
p
