HUMAN:MIF

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MIF (synonyms: GLIF, MMIF)
Protein Name(s)	Macrophage migration inhibitory factor MIF Glycosylation-inhibiting factor GIF L-dopachrome isomerase L-dopachrome tautomerase Phenylpyruvate tautomerase
External Links
UniProt	P14174
EMBL	M25639 L10612 Z23063 L19686 AF469046 EF611126 CR456520 AK311929 CR407644 CR541651 BT007148 DQ307455 CH471095 BC000447 BC007676 BC008914 BC013976 BC022414 BC053376 M95775
CCDS	CCDS13819.1
PIR	A48793
RefSeq	NP_002406.1
UniGene	Hs.407995
PDB	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H
PDBsum	1CA7 1CGQ 1GCZ 1GD0 1GIF 1LJT 1MIF 1P1G 2OOH 2OOW 2OOZ 3B9S 3CE4 3DJH 3DJI 3HOF 3IJG 3IJJ 3JSF 3JSG 3JTU 3L5P 3L5R 3L5S 3L5T 3L5U 3L5V 3SMB 3SMC 3U18 3WNR 3WNS 3WNT 4ETG 4EUI 4EVG 4F2K 4GRN 4GRO 4GRP 4GRQ 4GRR 4GRU 4GUM 4K9G 4OSF 4OYQ 4P01 4P0H
ProteinModelPortal	P14174
SMR	P14174
BioGrid	110428
DIP	DIP-31137N
IntAct	P14174
MINT	MINT-5000040
STRING	9606.ENSP00000215754
BindingDB	P14174
ChEMBL	CHEMBL2111430
PhosphoSite	P14174
DMDM	1170955
SWISS-2DPAGE	P14174
MaxQB	P14174
PaxDb	P14174
PeptideAtlas	P14174
PRIDE	P14174
DNASU	4282
Ensembl	ENST00000215754 ENST00000613839
GeneID	4282
KEGG	hsa:4282
UCSC	uc002zyr.1
CTD	4282
GeneCards	GC22P024236
H-InvDB	HIX0041297
HGNC	HGNC:7097
HPA	CAB005284 HPA003868
MIM	153620 604302
neXtProt	NX_P14174
Orphanet	85414
PharmGKB	PA30819
eggNOG	NOG08790
GeneTree	ENSGT00730000111101
HOGENOM	HOG000112325
HOVERGEN	HBG003240
InParanoid	P14174
KO	K07253
OMA	MGKPAQY
OrthoDB	EOG7GXPDN
PhylomeDB	P14174
TreeFam	TF313853
EvolutionaryTrace	P14174
GeneWiki	Macrophage_migration_inhibitory_factor
GenomeRNAi	4282
NextBio	16845
PRO	PR:P14174
Proteomes	UP000005640 UP000005640
Bgee	P14174
CleanEx	HS_MIF
ExpressionAtlas	P14174
Genevestigator	P14174
GO	GO:0009986 GO:0005737 GO:0005576 GO:0005615 GO:0070062 GO:0031982 GO:0042056 GO:0005125 GO:0005126 GO:0004167 GO:0050178 GO:0005102 GO:0019752 GO:0007569 GO:0008283 GO:0007166 GO:0030330 GO:0006954 GO:0045087 GO:0043066 GO:0090344 GO:0071157 GO:0032269 GO:0043518 GO:0010629 GO:1902166 GO:0002906 GO:0033033 GO:0050918 GO:0090238 GO:0030890 GO:2000343 GO:0050715 GO:0070374 GO:0048146 GO:0031666 GO:0043406 GO:0061081 GO:0033138 GO:0050731 GO:0042327 GO:0061078 GO:0010739 GO:0001516 GO:0070207 GO:0043030
InterPro	IPR001398 IPR019829 IPR014347
PANTHER	PTHR11954
Pfam	PF01187
ProDom	PD004816
SUPFAM	SSF55331
PROSITE	PS01158

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005576	extracellular region	PMID:27068509^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0007318)	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:21817065^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:0071222) occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0010760	negative regulation of macrophage chemotaxis	PMID:21817065^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	part_of:(GO:1990869)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21817065^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P30046	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	PMID:21817065^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	PMID:21817065^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(CHEBI:15999)	Seeded From UniProt	complete
part_of	GO:0031982	vesicle	PMID:19190083^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002202)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:20458337^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000639)	Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090344	negative regulation of cell aging	PMID:10562313^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	PMID:10562313^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	PMID:19602265^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:19602265^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019752	carboxylic acid metabolic process	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010739	positive regulation of protein kinase A signaling	PMID:17045821^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	PMID:10562313^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005126	cytokine receptor binding	PMID:17045821^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04233	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:12782713^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04233	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21817065^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001969)	Seeded From UniProt	complete
involved_in	GO:0070207	protein homotrimerization	PMID:17526494^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14174	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043030	regulation of macrophage activation	PMID:12782713^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004167	dopachrome isomerase activity	PMID:17526494^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001516	prostaglandin biosynthetic process	PMID:12782713^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	PMID:16285950^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20534506^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14174	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0042056	P		Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0090238	positive regulation of arachidonic acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0061081	positive regulation of myeloid leukocyte cytokine production involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0061078	positive regulation of prostaglandin secretion involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043406	positive regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0033033	negative regulation of myeloid cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0032269	negative regulation of cellular protein metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0002906	negative regulation of mature B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P34884 ensembl:ENSMUSP00000041149	P		Seeded From UniProt	complete
enables	GO:0004167	dopachrome isomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.3.3.12	F		Seeded From UniProt	complete
enables	GO:0050178	phenylpyruvate tautomerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:5.3.2.1	F		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-8950732 Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798748 Reactome:R-HSA-5676133	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0016853	isomerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0413	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Merk, M et al. (2011) The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc. Natl. Acad. Sci. U.S.A. 108 E577-85 PubMed GONUTS page
↑ Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Shi, X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25 595-606 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Hudson, JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J. Exp. Med. 190 1375-82 PubMed GONUTS page
↑ ^9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Leng, L et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197 1467-76 PubMed GONUTS page
↑ ^10.0 ^10.1 Verjans, E et al. (2009) Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer 9 230 PubMed GONUTS page
↑ ^11.0 ^11.1 Crichlow, GV et al. (2007) Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J. Biol. Chem. 282 23089-95 PubMed GONUTS page
↑ Wilson, JM et al. (2005) Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129 1485-503 PubMed GONUTS page
↑ Cho, Y et al. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc. Natl. Acad. Sci. U.S.A. 107 11313-8 PubMed GONUTS page

[PMID:27068509-1] Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page

[PMID:21817065-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Merk, M et al. (2011) The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc. Natl. Acad. Sci. U.S.A. 108 E577-85 PubMed GONUTS page

[PMID:19190083-3] Kesimer, M et al. (2009) Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 23 1858-68 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-5] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20458337-6] Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page

[PMID:17045821-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Shi, X et al. (2006) CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. Immunity 25 595-606 PubMed GONUTS page

[PMID:10562313-8] 8.0 ^8.1 ^8.2 Hudson, JD et al. (1999) A proinflammatory cytokine inhibits p53 tumor suppressor activity. J. Exp. Med. 190 1375-82 PubMed GONUTS page

[PMID:12782713-9] 9.00 ^9.01 ^9.02 ^9.03 ^9.04 ^9.05 ^9.06 ^9.07 ^9.08 ^9.09 ^9.10 ^9.11 ^9.12 ^9.13 Leng, L et al. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197 1467-76 PubMed GONUTS page

[PMID:19602265-10] 10.0 ^10.1 Verjans, E et al. (2009) Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer. BMC Cancer 9 230 PubMed GONUTS page

[PMID:17526494-11] 11.0 ^11.1 Crichlow, GV et al. (2007) Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J. Biol. Chem. 282 23089-95 PubMed GONUTS page

[PMID:16285950-12] Wilson, JM et al. (2005) Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 129 1485-503 PubMed GONUTS page

[PMID:20534506-13] Cho, Y et al. (2010) Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. Proc. Natl. Acad. Sci. U.S.A. 107 11313-8 PubMed GONUTS page

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