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HUMAN:MERTK
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MERTK (synonyms: MER) | |
| Protein Name(s) | Tyrosine-protein kinase Mer
Proto-oncogene c-Mer Receptor tyrosine kinase MerTK | |
| External Links | ||
| UniProt | Q12866 | |
| EMBL | U08023 AH010001 AC093675 AC104651 | |
| CCDS | CCDS2094.1 | |
| PIR | I38547 | |
| RefSeq | NP_006334.2 | |
| UniGene | Hs.306178 | |
| PDB | 2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA | |
| PDBsum | 2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA | |
| ProteinModelPortal | Q12866 | |
| SMR | Q12866 | |
| BioGrid | 115724 | |
| IntAct | Q12866 | |
| STRING | 9606.ENSP00000295408 | |
| BindingDB | Q12866 | |
| ChEMBL | CHEMBL3137284 | |
| GuidetoPHARMACOLOGY | 1837 | |
| MEROPS | I43.001 | |
| PhosphoSite | Q12866 | |
| DMDM | 160332297 | |
| MaxQB | Q12866 | |
| PaxDb | Q12866 | |
| PRIDE | Q12866 | |
| Ensembl | ENST00000295408 ENST00000421804 | |
| GeneID | 10461 | |
| KEGG | hsa:10461 | |
| UCSC | uc002thk.1 | |
| CTD | 10461 | |
| GeneCards | GC02P112656 | |
| GeneReviews | MERTK | |
| H-InvDB | HIX0002374 | |
| HGNC | HGNC:7027 | |
| HPA | HPA036196 | |
| MIM | 604705 613862 | |
| neXtProt | NX_Q12866 | |
| Orphanet | 791 | |
| PharmGKB | PA30759 | |
| eggNOG | COG0515 | |
| GeneTree | ENSGT00770000120499 | |
| HOGENOM | HOG000231685 | |
| HOVERGEN | HBG006346 | |
| InParanoid | Q12866 | |
| KO | K05117 | |
| OMA | NEIGWSA | |
| OrthoDB | EOG77DJ5C | |
| PhylomeDB | Q12866 | |
| TreeFam | TF317402 | |
| BRENDA | 2.7.10.1 | |
| Reactome | REACT_12051 | |
| SignaLink | Q12866 | |
| ChiTaRS | MERTK | |
| EvolutionaryTrace | Q12866 | |
| GeneWiki | MERTK | |
| GenomeRNAi | 10461 | |
| NextBio | 39667 | |
| PRO | PR:Q12866 | |
| Proteomes | UP000005640 | |
| Bgee | Q12866 | |
| CleanEx | HS_MERTK | |
| ExpressionAtlas | Q12866 | |
| Genevestigator | Q12866 | |
| GO | GO:0005737 GO:0005615 GO:0005887 GO:0001750 GO:0005886 GO:0016028 GO:0005524 GO:0004714 GO:0043277 GO:0007596 GO:0007166 GO:0007267 GO:0050900 GO:0001779 GO:0051250 GO:0018108 GO:0006909 GO:0030168 GO:0050766 GO:0043491 GO:0006468 GO:0060041 GO:0032940 GO:0007283 GO:0034446 GO:0060068 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR007110 IPR013783 IPR013098 IPR003599 IPR011009 IPR000719 IPR017441 IPR001245 IPR008266 IPR020635 | |
| Pfam | PF00041 PF07679 PF07714 | |
| PRINTS | PR00109 | |
| SMART | SM00060 SM00409 SM00219 | |
| SUPFAM | SSF49265 SSF56112 | |
| PROSITE | PS50853 PS50835 PS00107 PS50011 PS00109 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:2000107 |
negative regulation of leukocyte apoptotic process |
ECO:0000315 |
P |
It is shown in figure 3 that a knockout mutation in MerTK leads to increased apoptosis rates in response to chemotherapeutic agents. |
complete | |||||
| GO:0071866 |
negative regulation of apoptotic process in bone marrow |
ECO:0000315 |
P |
It is shown in figure 3 that a knockout mutation in MerTK leads to increased apoptosis rates in response to chemotherapeutic agents. |
complete | |||||
|
involved_in |
GO:2000107 |
negative regulation of leukocyte apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016028 |
rhabdomere |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050766 |
positive regulation of phagocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0002586) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002586) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0002586) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015380 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0017147 |
Wnt-protein binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0015380 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016477 |
cell migration |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347244 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016055 |
Wnt signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101766 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007399 |
nervous system development |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347244 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007169 |
transmembrane receptor protein tyrosine kinase signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1347244 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003366 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0003733 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004713 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004714 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006909 |
phagocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57097 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57097 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0001750 |
photoreceptor outer segment |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P57097 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097350 |
neutrophil clearance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060068 |
vagina development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0060041 |
retina development in camera-type eye |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051250 |
negative regulation of lymphocyte activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043491 |
protein kinase B signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043277 |
apoptotic cell clearance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034446 |
substrate adhesion-dependent cell spreading |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032940 |
secretion by cell |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030168 |
platelet activation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007283 |
spermatogenesis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001818 |
negative regulation of cytokine production |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001779 |
natural killer cell differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q60805 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004714 |
transmembrane receptor protein tyrosine kinase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050900 |
leukocyte migration |
Reactome:R-HSA-202733 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-202710 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Brandao, LN et al. (2013) Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia. Blood Cancer J 3 e101 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Carr, AJ et al. (2009) Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay. Mol. Vis. 15 283-95 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Karl, MO et al. (2008) Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium. Cell. Signal. 20 1159-68 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Graham, DK et al. (1994) Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5 647-57 PubMed GONUTS page
c
n
- GO:0001779 ! natural killer cell differentiation
- GO:0071866 ! negative regulation of apoptotic process in bone marrow cell
- GO:2000107 ! negative regulation of leukocyte apoptotic process
- GO:0051250 ! negative regulation of lymphocyte activation
- GO:0001818 ! negative regulation of cytokine production
- GO:0007399 ! nervous system development
- GO:0097350 ! neutrophil clearance
- GO:0000166 ! nucleotide binding
p
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0006909 ! phagocytosis
- GO:0043491 ! phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0016310 ! phosphorylation
- GO:0001750 ! photoreceptor outer segment
- GO:0005886 ! plasma membrane
- GO:0030168 ! platelet activation
- GO:0050766 ! positive regulation of phagocytosis
- Primates
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004713 ! protein tyrosine kinase activity
s
t