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HUMAN:MBL2
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | MBL2 (synonyms: COLEC1, MBL) | |
Protein Name(s) | Mannose-binding protein C
MBP-C Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin | |
External Links | ||
UniProt | P11226 | |
EMBL | X15422 X15954 X15955 X15956 X15957 AF080510 AF080508 AF080509 Y16576 Y16577 Y16578 Y16579 Y16580 Y16581 Y16582 AF360991 AY826184 DQ217939 EU596574 CH471083 CH471083 BC096179 BC096180 BC069338 BC096181 BC096182 AF482699 AF482700 | |
CCDS | CCDS7247.1 | |
PIR | JL0115 | |
RefSeq | NP_000233.1 XP_006717924.1 | |
UniGene | Hs.499674 | |
PDB | 1HUP | |
PDBsum | 1HUP | |
ProteinModelPortal | P11226 | |
SMR | P11226 | |
BioGrid | 110323 | |
IntAct | P11226 | |
MINT | MINT-6630459 | |
STRING | 9606.ENSP00000363079 | |
ChEMBL | CHEMBL1795113 | |
DMDM | 126676 | |
MaxQB | P11226 | |
PaxDb | P11226 | |
PeptideAtlas | P11226 | |
PRIDE | P11226 | |
DNASU | 4153 | |
Ensembl | ENST00000373968 | |
GeneID | 4153 | |
KEGG | hsa:4153 | |
UCSC | uc001jjt.3 | |
CTD | 4153 | |
GeneCards | GC10M054525 | |
HGNC | HGNC:6922 | |
HPA | CAB016782 HPA002027 | |
MIM | 154545 610424 614372 | |
neXtProt | NX_P11226 | |
PharmGKB | PA30665 | |
eggNOG | NOG265984 | |
GeneTree | ENSGT00700000104102 | |
HOVERGEN | HBG108270 | |
InParanoid | P11226 | |
KO | K03991 | |
OMA | LCAQFQG | |
OrthoDB | EOG7VTDPW | |
PhylomeDB | P11226 | |
TreeFam | TF330481 | |
Reactome | REACT_7964 REACT_8024 | |
EvolutionaryTrace | P11226 | |
GeneWiki | Mannan-binding_lectin | |
GenomeRNAi | 4153 | |
NextBio | 16342 | |
PMAP-CutDB | P11226 | |
PRO | PR:P11226 | |
Proteomes | UP000005640 | |
Bgee | P11226 | |
CleanEx | HS_MBL2 | |
ExpressionAtlas | P11226 | |
Genevestigator | P11226 | |
GO | GO:0009986 GO:0005581 GO:0005576 GO:0005615 GO:0048306 GO:0005537 GO:0005102 GO:0006953 GO:0006956 GO:0006958 GO:0001867 GO:0042742 GO:0050830 GO:0045087 GO:0051873 GO:0044130 GO:0048525 GO:0008228 GO:0050766 GO:0006979 | |
Gene3D | 3.10.100.10 | |
InterPro | IPR001304 IPR016186 IPR018378 IPR016187 IPR008160 | |
Pfam | PF01391 PF00059 | |
SMART | SM00034 | |
SUPFAM | SSF56436 | |
PROSITE | PS00615 PS50041 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
involved_in |
GO:0048525 |
negative regulation of viral process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001969) |
Seeded From UniProt |
complete | ||
enables |
GO:0005537 |
mannose binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
activated_by:(CHEBI:29108) |
Seeded From UniProt |
complete | ||
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0048306 |
calcium-dependent protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005537 |
mannose binding |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000353 |
physical interaction evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0062023 |
collagen-containing extracellular matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:109613 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0031012 |
extracellular matrix |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:106591 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001522730 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:2684334 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005537 |
mannose binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001522730 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005509 |
calcium ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001522730 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0003429 |
growth plate cartilage chondrocyte morphogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:106591 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001522730 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0044130 |
negative regulation of growth of symbiont in host |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051873 |
killing by host of symbiont cells |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050830 |
defense response to Gram-positive bacterium |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050766 |
positive regulation of phagocytosis |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0044130 |
negative regulation of growth of symbiont in host |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P41317 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005537 |
mannose binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042742 |
defense response to bacterium |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0009986 |
cell surface |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008228 |
opsonization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006953 |
acute-phase response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005537 |
mannose binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006956 |
complement activation |
Reactome:R-HSA-166663 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-166792 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
involved_in |
GO:0001867 |
complement activation, lectin pathway |
Reactome:R-HSA-166662 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005537 |
mannose binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0001867 |
complement activation, lectin pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005581 |
collagen trimer |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0030246 |
carbohydrate binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006958 |
complement activation, classical pathway |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Job, ER et al. (2013) Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. PLoS ONE 8 e59623 PubMed GONUTS page
- ↑ 2.0 2.1 Cseh, S et al. (2002) Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J. Immunol. 169 5735-43 PubMed GONUTS page
- ↑ Teillet, F et al. (2008) Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 283 25715-24 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Collard, CD et al. (2001) Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am. J. Pathol. 159 1045-54 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Shi, L et al. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J. Exp. Med. 199 1379-90 PubMed GONUTS page
- ↑ Lipscombe, RJ et al. (1992) High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum. Mol. Genet. 1 709-15 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 8.3 8.4 Wright, SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170 1231-41 PubMed GONUTS page
c
- GO:0048306 ! calcium-dependent protein binding
- GO:0005509 ! calcium ion binding
- GO:0030246 ! carbohydrate binding
- Catarrhini
- GO:0009986 ! cell surface
- Chordata
- GO:0062023 ! collagen-containing extracellular matrix
- GO:0005581 ! collagen trimer
- GO:0006958 ! complement activation, classical pathway
- GO:0006956 ! complement activation
- GO:0001867 ! complement activation, lectin pathway
- Craniata
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