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HUMAN:MBL2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MBL2 (synonyms: COLEC1, MBL)
Protein Name(s) Mannose-binding protein C

MBP-C Collectin-1 MBP1 Mannan-binding protein Mannose-binding lectin

External Links
UniProt P11226
EMBL X15422
X15954
X15955
X15956
X15957
AF080510
AF080508
AF080509
Y16576
Y16577
Y16578
Y16579
Y16580
Y16581
Y16582
AF360991
AY826184
DQ217939
EU596574
CH471083
CH471083
BC096179
BC096180
BC069338
BC096181
BC096182
AF482699
AF482700
CCDS CCDS7247.1
PIR JL0115
RefSeq NP_000233.1
XP_006717924.1
UniGene Hs.499674
PDB 1HUP
PDBsum 1HUP
ProteinModelPortal P11226
SMR P11226
BioGrid 110323
IntAct P11226
MINT MINT-6630459
STRING 9606.ENSP00000363079
ChEMBL CHEMBL1795113
DMDM 126676
MaxQB P11226
PaxDb P11226
PeptideAtlas P11226
PRIDE P11226
DNASU 4153
Ensembl ENST00000373968
GeneID 4153
KEGG hsa:4153
UCSC uc001jjt.3
CTD 4153
GeneCards GC10M054525
HGNC HGNC:6922
HPA CAB016782
HPA002027
MIM 154545
610424
614372
neXtProt NX_P11226
PharmGKB PA30665
eggNOG NOG265984
GeneTree ENSGT00700000104102
HOVERGEN HBG108270
InParanoid P11226
KO K03991
OMA LCAQFQG
OrthoDB EOG7VTDPW
PhylomeDB P11226
TreeFam TF330481
Reactome REACT_7964
REACT_8024
EvolutionaryTrace P11226
GeneWiki Mannan-binding_lectin
GenomeRNAi 4153
NextBio 16342
PMAP-CutDB P11226
PRO PR:P11226
Proteomes UP000005640
Bgee P11226
CleanEx HS_MBL2
ExpressionAtlas P11226
Genevestigator P11226
GO GO:0009986
GO:0005581
GO:0005576
GO:0005615
GO:0048306
GO:0005537
GO:0005102
GO:0006953
GO:0006956
GO:0006958
GO:0001867
GO:0042742
GO:0050830
GO:0045087
GO:0051873
GO:0044130
GO:0048525
GO:0008228
GO:0050766
GO:0006979
Gene3D 3.10.100.10
InterPro IPR001304
IPR016186
IPR018378
IPR016187
IPR008160
Pfam PF01391
PF00059
SMART SM00034
SUPFAM SSF56436
PROSITE PS00615
PS50041

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0048525

negative regulation of viral process

PMID:23544079[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:23544079[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23544079[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(UBERON:0001969)

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

PMID:23544079[1]

ECO:0000314

direct assay evidence used in manual assertion

F

activated_by:(CHEBI:29108)

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:12421953[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O00187

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:12421953[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P48740

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:18596036[3]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P48740

F

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

PMID:11549596[4]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

PMID:11549596[4]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

PMID:11549596[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04264

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

PMID:11549596[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P04264

P

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:109613
MGI:MGI:1341272
MGI:MGI:1921449
MGI:MGI:2179729
MGI:MGI:2684334
MGI:MGI:88462
PANTHER:PTN001523162
UniProtKB:O43405
ZFIN:ZDB-GENE-030131-9889

C

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106591
MGI:MGI:109613
MGI:MGI:1278313
MGI:MGI:1328350
MGI:MGI:1921449
MGI:MGI:2179729
MGI:MGI:88459
MGI:MGI:88460
MGI:MGI:88461
PANTHER:PTN001523162
UniProtKB:P12111

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001522730
RGD:3055
UniProtKB:P11226

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2684334
MGI:MGI:88461
MGI:MGI:96924
PANTHER:PTN001523162
RGD:3055
RGD:67380
UniProtKB:P11226
UniProtKB:Q5GFL6

C

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001522730
RGD:3055
UniProtKB:P11226

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001522730
RGD:3055

F

Seeded From UniProt

complete

involved_in

GO:0003429

growth plate cartilage chondrocyte morphogenesis

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106591
PANTHER:PTN001523162

P

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001522730
RGD:3055
UniProtKB:P11226

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:15148336[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0044130

negative regulation of growth of symbiont in host

PMID:15148336[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

PMID:15148336[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051873

killing by host of symbiont cells

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

P

Seeded From UniProt

complete

involved_in

GO:0050766

positive regulation of phagocytosis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

P

Seeded From UniProt

complete

involved_in

GO:0044130

negative regulation of growth of symbiont in host

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

C

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P41317
ensembl:ENSMUSP00000025797

P

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037570

P

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR037570

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:1304173[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0042742

defense response to bacterium

PMID:2477488[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:2477488[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0008228

opsonization

PMID:2477488[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006953

acute-phase response

PMID:2477488[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

PMID:2477488[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006956

complement activation

Reactome:R-HSA-166663

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-166792
Reactome:R-HSA-166753
Reactome:R-HSA-166726
Reactome:R-HSA-166721

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

Reactome:R-HSA-166662

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005537

mannose binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0465

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1018

P

Seeded From UniProt

complete

part_of

GO:0005581

collagen trimer

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0176

C

Seeded From UniProt

complete

enables

GO:0030246

carbohydrate binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0430

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

involved_in

GO:0006958

complement activation, classical pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0180

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Job, ER et al. (2013) Serum amyloid P is a sialylated glycoprotein inhibitor of influenza A viruses. PLoS ONE 8 e59623 PubMed GONUTS page
  2. ↑ 2.0 2.1 Cseh, S et al. (2002) Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J. Immunol. 169 5735-43 PubMed GONUTS page
  3. ↑ Teillet, F et al. (2008) Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 283 25715-24 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 Collard, CD et al. (2001) Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am. J. Pathol. 159 1045-54 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Shi, L et al. (2004) Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J. Exp. Med. 199 1379-90 PubMed GONUTS page
  7. ↑ Lipscombe, RJ et al. (1992) High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum. Mol. Genet. 1 709-15 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 Wright, SD et al. (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170 1231-41 PubMed GONUTS page
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