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HUMAN:MBB1A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MYBBP1A (synonyms: P160)
Protein Name(s) Myb-binding protein 1A
External Links
UniProt Q9BQG0
EMBL AF147709
BC000641
BC050546
AL136595
AL133098
CCDS CCDS11046.1
CCDS42238.1
PIR T42680
RefSeq NP_001099008.1
NP_055335.2
UniGene Hs.22824
Hs.701718
ProteinModelPortal Q9BQG0
BioGrid 115770
IntAct Q9BQG0
MINT MINT-1150245
STRING 9606.ENSP00000370968
PhosphoSite Q9BQG0
DMDM 71153825
SWISS-2DPAGE Q9BQG0
MaxQB Q9BQG0
PaxDb Q9BQG0
PRIDE Q9BQG0
DNASU 10514
Ensembl ENST00000254718
ENST00000381556
GeneID 10514
KEGG hsa:10514
UCSC uc002fxz.4
uc002fyb.4
CTD 10514
GeneCards GC17M004442
H-InvDB HIX0013445
HGNC HGNC:7546
HPA HPA005466
MIM 604885
neXtProt NX_Q9BQG0
PharmGKB PA31346
eggNOG NOG313877
GeneTree ENSGT00390000017457
HOGENOM HOG000113488
HOVERGEN HBG081961
InParanoid Q9BQG0
KO K02331
OMA SLWLVIT
PhylomeDB Q9BQG0
TreeFam TF317401
ChiTaRS MYBBP1A
GeneWiki MYBBP1A
GenomeRNAi 10514
NextBio 39876
PMAP-CutDB Q9BQG0
PRO PR:Q9BQG0
Proteomes UP000005640
Bgee Q9BQG0
CleanEx HS_MYBBP1A
Genevestigator Q9BQG0
GO GO:0005737
GO:0043231
GO:0016020
GO:0042564
GO:0005730
GO:0005634
GO:0003887
GO:0044822
GO:0043565
GO:0008134
GO:0042149
GO:0072332
GO:0045892
GO:0006913
GO:0001649
GO:0071158
GO:0006355
GO:0022904
GO:0006351
InterPro IPR016024
IPR007015
PANTHER PTHR13213
Pfam PF04931
SUPFAM SSF48371

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:2000210

positive regulation of anoikis

PMID:23388179[1]

ECO:0000315

P

Figure 3. MYBBP1A induces anoikis in normal breast and breast cancer cells through siRNA knockdown.

complete
CACAO 6537

involved_in

GO:2000210

positive regulation of anoikis

PMID:23388179[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

P

Seeded From UniProt

complete

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:16210410[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000134)|part_of:(CL:0000062)

Seeded From UniProt

complete

involved_in

GO:0001649

osteoblast differentiation

PMID:16210410[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

results_in_determination_of:(CL:0000134)

Seeded From UniProt

complete

involved_in

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:21471221[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071158

positive regulation of cell cycle arrest

PMID:21471221[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22681889[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:22658674[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0042564

NLS-dependent protein nuclear import complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

C

Seeded From UniProt

complete

involved_in

GO:0042149

cellular response to glucose starvation

PMID:21471221[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:21471221[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21471221[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q7TPV4

C

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000996181
RGD:62062

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106181
PANTHER:PTN000324922
SGD:S000000781
UniProtKB:Q9BQG0

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:106181
PANTHER:PTN000996181

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0043565

sequence-specific DNA binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35821
ensembl:ENSRNOP00000021134

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35821
ensembl:ENSRNOP00000021134

C

Seeded From UniProt

complete

enables

GO:0070888

E-box binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

F

Seeded From UniProt

complete

involved_in

GO:0045892

negative regulation of transcription, DNA-templated

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

P

Seeded From UniProt

complete

part_of

GO:0042564

NLS-dependent protein nuclear import complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

C

Seeded From UniProt

complete

involved_in

GO:0032922

circadian regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

P

Seeded From UniProt

complete

involved_in

GO:0022904

respiratory electron transport chain

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

C

Seeded From UniProt

complete

enables

GO:0003714

transcription corepressor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q7TPV4
ensembl:ENSMUSP00000044827

F

Seeded From UniProt

complete

enables

GO:0003677

DNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007015

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007015

C

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007015

P

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007015

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:10644447[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006355

regulation of transcription, DNA-templated

PMID:10644447[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045815

positive regulation of gene expression, epigenetic

Reactome:R-HSA-5250924

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-5250947
Reactome:R-HSA-5250938
Reactome:R-HSA-5250930

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0048511

rhythmic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0090

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0042254

ribosome biogenesis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0690

P

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Akaogi, K et al. (2013) MYBBP1A suppresses breast cancer tumorigenesis by enhancing the p53 dependent anoikis. BMC Cancer 13 65 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 Foster, LJ et al. (2005) Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Stem Cells 23 1367-77 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 Kumazawa, T et al. (2011) Novel nucleolar pathway connecting intracellular energy status with p53 activation. J. Biol. Chem. 286 20861-9 PubMed GONUTS page
  5. ↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  6. ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. ↑ 8.0 8.1 Keough, R et al. (1999) Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3. Genomics 62 483-9 PubMed GONUTS page
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