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HUMAN:MACD1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MACROD1 (synonyms: LRP16)
Protein Name(s) O-acetyl-ADP-ribose deacetylase MACROD1

MACRO domain-containing protein 1 Protein LRP16 [Protein ADP-ribosylglutamate] hydrolase

External Links
UniProt Q9BQ69
EMBL AF202922
BC000270
BC003188
BC007297
BC008316
CCDS CCDS8056.1
RefSeq NP_054786.2
UniGene Hs.602898
PDB 2X47
PDBsum 2X47
ProteinModelPortal Q9BQ69
SMR Q9BQ69
BioGrid 118813
IntAct Q9BQ69
STRING 9606.ENSP00000255681
PhosphoSite Q9BQ69
DMDM 32129719
MaxQB Q9BQ69
PaxDb Q9BQ69
PeptideAtlas Q9BQ69
PRIDE Q9BQ69
Ensembl ENST00000255681
GeneID 28992
KEGG hsa:28992
UCSC uc001nyh.3
CTD 28992
GeneCards GC11M063767
HGNC HGNC:29598
HPA HPA041031
MIM 610400
neXtProt NX_Q9BQ69
PharmGKB PA162394816
eggNOG COG2110
GeneTree ENSGT00520000055566
HOGENOM HOG000086960
HOVERGEN HBG052356
InParanoid Q9BQ69
OMA KITCGYR
OrthoDB EOG7D2FFN
PhylomeDB Q9BQ69
TreeFam TF341440
ChiTaRS MACROD1
EvolutionaryTrace Q9BQ69
GenomeRNAi 28992
NextBio 51921
PRO PR:Q9BQ69
Proteomes UP000005640
Bgee Q9BQ69
CleanEx HS_MACROD1
Genevestigator Q9BQ69
GO GO:0005739
GO:0005634
GO:0019213
GO:0016798
GO:0006974
GO:0051725
GO:0042278
InterPro IPR002589
Pfam PF01661
SMART SM00506
PROSITE PS51154

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0140291

peptidyl-glutamate ADP-deribosylation

PMID:23474714[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0140293

ADP-ribosylglutamate hydrolase activity

PMID:23474714[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051725

protein de-ADP-ribosylation

PMID:23474712[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042278

purine nucleoside metabolic process

PMID:21257746[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019213

deacetylase activity

PMID:21257746[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0016798

hydrolase activity, acting on glycosyl bonds

PMID:23474712[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:23474712[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:23474712[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Rosenthal, F et al. (2013) Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases. Nat. Struct. Mol. Biol. 20 502-7 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Jankevicius, G et al. (2013) A family of macrodomain proteins reverses cellular mono-ADP-ribosylation. Nat. Struct. Mol. Biol. 20 508-14 PubMed GONUTS page
  3. 3.0 3.1 Chen, D et al. (2011) Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. J. Biol. Chem. 286 13261-71 PubMed GONUTS page