HUMAN:M3K1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAP3K1 (synonyms: MAPKKK1, MEKK, MEKK1)
Protein Name(s)	Mitogen-activated protein kinase kinase kinase 1 MAPK/ERK kinase kinase 1 MEK kinase 1 MEKK 1
External Links
UniProt	Q13233
EMBL	AC008937 AF042838 U29671
CCDS	CCDS43318.1
PIR	G01887
RefSeq	NP_005912.1
UniGene	Hs.653654
ProteinModelPortal	Q13233
SMR	Q13233
BioGrid	110378
DIP	DIP-27520N
IntAct	Q13233
MINT	MINT-143285
STRING	9606.ENSP00000382423
BindingDB	Q13233
ChEMBL	CHEMBL3956
GuidetoPHARMACOLOGY	2069
PhosphoSite	Q13233
DMDM	218512139
SWISS-2DPAGE	Q13233
MaxQB	Q13233
PaxDb	Q13233
PRIDE	Q13233
DNASU	4214
Ensembl	ENST00000399503
GeneID	4214
KEGG	hsa:4214
UCSC	uc003jqw.4
CTD	4214
GeneCards	GC05P056110
GeneReviews	MAP3K1
H-InvDB	HIX0024789
HGNC	HGNC:6848
HPA	CAB004500 HPA046509
MIM	600982 613762
neXtProt	NX_Q13233
Orphanet	242 251510
PharmGKB	PA30592
eggNOG	COG0515
GeneTree	ENSGT00760000119077
HOGENOM	HOG000113437
HOVERGEN	HBG006302
InParanoid	Q13233
KO	K04416
OMA	STHFTRM
OrthoDB	EOG7MSMNV
PhylomeDB	Q13233
TreeFam	TF105112
Reactome	REACT_163701 REACT_24969 REACT_25024 REACT_27215 REACT_6788
SignaLink	Q13233
GeneWiki	MAP3K1
GenomeRNAi	4214
NextBio	16613
PRO	PR:Q13233
Proteomes	UP000005640
Bgee	Q13233
CleanEx	HS_MAP3K1
Genevestigator	Q13233
GO	GO:0005829 GO:0005524 GO:0008545 GO:0004709 GO:0004672 GO:0019901 GO:0008270 GO:0000186 GO:0008637 GO:0071260 GO:0003382 GO:0061029 GO:0038095 GO:0045087 GO:0002755 GO:0030838 GO:0006468 GO:0030334 GO:0034166 GO:0034134 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0007179 GO:0042060
Gene3D	3.30.40.10
InterPro	IPR016024 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 IPR001841 IPR013083 IPR007527
Pfam	PF00069
SMART	SM00184 SM00220
SUPFAM	SSF48371 SSF56112
PROSITE	PS00107 PS50011 PS00108 PS50089 PS50966

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17906693^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15208	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9808624^[3]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	PMID:9808624^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P	Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:9639556^[5]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:7997270^[6]	ECO:0000269	experimental evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:15001576^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:0004672	protein kinase activity	PMID:21129722^[8]	ECO:0000314			F	In figures 4A the effects MAP3K1 mutations on phosphorylation of downstream targets were examined by quantitative immunoblot analysis. Levels of phospho-ERK were increased in all the mutant cell lines in comparison to wild-type	complete CACAO 6394
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004709	P	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004709	P	Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004709	P	Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004709	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007527	F	Seeded From UniProt	complete
enables	GO:0004709	MAP kinase kinase kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.25	F	Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-933530 Reactome:R-HSA-2730896 Reactome:R-HSA-2730868 Reactome:R-HSA-166869	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	Reactome:R-HSA-933530	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-HSA-975871 Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ Enomoto, A et al. (2008) Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Oncogene 27 1930-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Xia, Y et al. (1998) JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12 3369-81 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Cuenda, A & Dorow, DS (1998) Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. Biochem. J. 333 ( Pt 1) 11-5 PubMed GONUTS page
↑ Yan, M et al. () Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372 798-800 PubMed GONUTS page
↑ Xu, LG et al. (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279 17278-82 PubMed GONUTS page
↑ Pearlman, A et al. (2010) Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination. Am. J. Hum. Genet. 87 898-904 PubMed GONUTS page

[PMID:19593445-1] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:17906693-2] Enomoto, A et al. (2008) Negative regulation of MEKK1/2 signaling by serine-threonine kinase 38 (STK38). Oncogene 27 1930-8 PubMed GONUTS page

[PMID:9808624-3] 3.0 ^3.1 Xia, Y et al. (1998) JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12 3369-81 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9639556-5] Cuenda, A & Dorow, DS (1998) Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1. Biochem. J. 333 ( Pt 1) 11-5 PubMed GONUTS page

[PMID:7997270-6] Yan, M et al. () Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372 798-800 PubMed GONUTS page

[PMID:15001576-7] Xu, LG et al. (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279 17278-82 PubMed GONUTS page

[PMID:21129722-8] Pearlman, A et al. (2010) Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination. Am. J. Hum. Genet. 87 898-904 PubMed GONUTS page

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HUMAN:M3K1

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