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PMID:15001576
| Citation |
Xu, LG, Li, LY and Shu, HB (2004) TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. 279:17278-82 |
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| Abstract |
The tumor necrosis factor receptor-associated factor (TRAF) protein family members are critically involved in activation of NF-kappaB, JNK, and p38 activation triggered by tumor necrosis factor (TNF) receptor family members and toll/interleukin-1 receptor (TIR)-containing receptors. TRAF proteins (except for TRAF1) contain an N-terminal RING finger domain that is essential for their functions. In this report, we identified a protein designated as TRAF7, which contains a RING finger domain and a zinc finger domain that are mostly conserved with those of TRAFs. TRAF7 also contains seven WD40 repeats at its C terminus. TRAF7 specifically interacted with MEKK3 and potentiated MEKK3-mediated AP1 and CHOP activation. Depletion of TRAF7 by antisense RNA inhibited MEKK3-mediated AP1 and CHOP activation. Moreover, overexpression of TRAF7 induced caspase-dependent apoptosis. Domain mapping experiments indicated that TRAF7 potentiated MEKK3-mediated AP1 and CHOP activation and induced apoptosis through distinct domains. Our studies identified a novel TRAF family member that is involved in MEKK3 signaling and apoptosis. |
| Links |
PubMed Online version:10.1074/jbc.C400063200 |
| Keywords |
Amino Acid Sequence; Apoptosis; Blotting, Northern; Blotting, Western; CCAAT-Enhancer-Binding Proteins/physiology; Carrier Proteins/chemistry; Carrier Proteins/physiology; Caspases/metabolism; Cell Death; DNA Fragmentation; Genes, Reporter; Humans; Luciferases/metabolism; MAP Kinase Kinase Kinase 3; MAP Kinase Kinase Kinases/chemistry; Mitogen-Activated Protein Kinases/metabolism; Models, Genetic; Molecular Sequence Data; Plasmids/metabolism; Precipitin Tests; Protein Structure, Tertiary; Receptors, Tumor Necrosis Factor/chemistry; Sequence Homology, Amino Acid; Tissue Distribution; Transcription Factor AP-1/physiology; Transcription Factor CHOP; Transcription Factors/physiology; Transfection; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Zinc Fingers; p38 Mitogen-Activated Protein Kinases |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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