HUMAN:LYSC

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LYZ (synonyms: LZM)
Protein Name(s)	Lysozyme C 1,4-beta-N-acetylmuramidase C
External Links
UniProt	P61626
EMBL	M21119 J03801 M19045 X14008 U25677 BC004147
CCDS	CCDS8989.1
PIR	S04938
RefSeq	NP_000230.1
UniGene	Hs.524579
PDB	133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7
PDBsum	133L 134L 1B5U 1B5V 1B5W 1B5X 1B5Y 1B5Z 1B7L 1B7M 1B7N 1B7O 1B7P 1B7Q 1B7R 1B7S 1BB3 1BB4 1BB5 1C43 1C45 1C46 1C7P 1CJ6 1CJ7 1CJ8 1CJ9 1CKC 1CKD 1CKF 1CKG 1CKH 1D6P 1D6Q 1DI3 1DI4 1DI5 1EQ4 1EQ5 1EQE 1GAY 1GAZ 1GB0 1GB2 1GB3 1GB5 1GB6 1GB7 1GB8 1GB9 1GBO 1GBW 1GBX 1GBY 1GBZ 1GDW 1GDX 1GE0 1GE1 1GE2 1GE3 1GE4 1GEV 1GEZ 1GF0 1GF3 1GF4 1GF5 1GF6 1GF7 1GF8 1GF9 1GFA 1GFE 1GFG 1GFH 1GFJ 1GFK 1GFR 1GFT 1GFU 1GFV 1HNL 1I1Z 1I20 1I22 1INU 1IOC 1IP1 1IP2 1IP3 1IP4 1IP5 1IP6 1IP7 1IWT 1IWU 1IWV 1IWW 1IWX 1IWY 1IWZ 1IX0 1IY3 1IY4 1JKA 1JKB 1JKC 1JKD 1JSF 1JWR 1LAA 1LHH 1LHI 1LHJ 1LHK 1LHL 1LHM 1LMT 1LOZ 1LYY 1LZ1 1LZ4 1LZ5 1LZ6 1LZR 1LZS 1OP9 1OUA 1OUB 1OUC 1OUD 1OUE 1OUF 1OUG 1OUH 1OUI 1OUJ 1QSW 1RE2 1REM 1REX 1REY 1REZ 1TAY 1TBY 1TCY 1TDY 1UBZ 1W08 1WQM 1WQN 1WQO 1WQP 1WQQ 1WQR 1YAM 1YAN 1YAO 1YAP 1YAQ 207L 208L 2BQA 2BQB 2BQC 2BQD 2BQE 2BQF 2BQG 2BQH 2BQI 2BQJ 2BQK 2BQL 2BQM 2BQN 2BQO 2HEA 2HEB 2HEC 2HED 2HEE 2HEF 2LHM 2MEA 2MEB 2MEC 2MED 2MEE 2MEF 2MEG 2MEH 2MEI 2NWD 2ZIJ 2ZIK 2ZIL 2ZWB 3EBA 3FE0 3LHM 3LN2 4I0C 4ML7
ProteinModelPortal	P61626
SMR	P61626
BioGrid	110247
IntAct	P61626
MINT	MINT-5002660
STRING	9606.ENSP00000261267
DrugBank	DB00128
CAZy	GH22
PhosphoSite	P61626
DMDM	48428995
UCD-2DPAGE	P61626
MaxQB	P61626
PaxDb	P61626
PeptideAtlas	P61626
PRIDE	P61626
DNASU	4069
Ensembl	ENST00000261267
GeneID	4069
KEGG	hsa:4069
UCSC	uc001suw.2
CTD	4069
GeneCards	GC12P069681
HGNC	HGNC:6740
HPA	CAB000055 HPA048284
MIM	105200 153450
neXtProt	NX_P61626
Orphanet	93561
PharmGKB	PA30503
eggNOG	NOG85133
GeneTree	ENSGT00550000074398
HOGENOM	HOG000037357
HOVERGEN	HBG052297
InParanoid	P61626
KO	K13915
OMA	LQDNIAD
OrthoDB	EOG7BW0M5
PhylomeDB	P61626
TreeFam	TF324882
Reactome	REACT_75925
ChiTaRS	LYZ
EvolutionaryTrace	P61626
GeneWiki	Lysozyme
GenomeRNAi	4069
NextBio	15952
PRO	PR:P61626
Proteomes	UP000005640
Bgee	P61626
CleanEx	HS_LYZ
ExpressionAtlas	P61626
Genevestigator	P61626
GO	GO:0005576 GO:0005615 GO:0070062 GO:0042802 GO:0003796 GO:0016998 GO:0019835 GO:0042742 GO:0006954 GO:0001895
InterPro	IPR001916 IPR019799 IPR000974 IPR023346 IPR030056
PANTHER	PTHR11407:SF22
Pfam	PF00062
PRINTS	PR00137 PR00135
SMART	SM00263
SUPFAM	SSF53955
PROSITE	PS00128 PS51348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005615	extracellular space	PMID:21805676^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031640	killing of cells of other organism	PMID:9727055^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21093056^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21093056^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	PMID:21093056^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22664934^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0001895	retina homeostasis	PMID:23580065^[8]	ECO:0007007	high throughput expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96897 MGI:MGI:96902 PANTHER:PTN000892307 RGD:3026 UniProtKB:P61626	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96897 MGI:MGI:96902 PANTHER:PTN000892307 RGD:1308401 RGD:3026	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23353684^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P61626	F		Seeded From UniProt	complete
enables	GO:0003796	lysozyme activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000974 InterPro:IPR030056	F		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030056	P		Seeded From UniProt	complete
enables	GO:0003796	lysozyme activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.2.1.17	F		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:366724^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:2829884^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003796	lysozyme activity	PMID:2829884^[13] Reactome:R-HSA-8862320	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:1904724	tertiary granule lumen	Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035580	specific granule lumen	Reactome:R-HSA-6798749	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019730	antimicrobial humoral response	Reactome:R-HSA-6803157	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-977136 Reactome:R-HSA-976734 Reactome:R-HSA-8862320 Reactome:R-HSA-8862300 Reactome:R-HSA-6798751 Reactome:R-HSA-6798749 Reactome:R-HSA-6798745	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0016798	hydrolase activity, acting on glycosyl bonds	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0326	F		Seeded From UniProt	complete
involved_in	GO:0019835	cytolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0081	P		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0081	F		Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0081 UniProtKB-KW:KW-0326	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0081	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fornander, L et al. (2011) Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Proteomics Clin Appl 5 513-22 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Bals, R et al. (1998) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102 874-80 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Huang, P et al. (2011) Characterization and expression of HLysG2, a basic goose-type lysozyme from the human eye and testis. Mol. Immunol. 48 524-31 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ ^8.0 ^8.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page
↑ ^10.0 ^10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Wyatt, AR et al. (2013) Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms. FEBS Lett. 587 398-403 PubMed GONUTS page
↑ Reitamo, S et al. () Human lysozyme (origin and distribution in health and disease). Ric Clin Lab 8 211-31 PubMed GONUTS page
↑ ^13.0 ^13.1 Yoshimura, K et al. (1988) Human lysozyme: sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 150 794-801 PubMed GONUTS page

[PMID:21805676-1] Fornander, L et al. (2011) Innate immunity proteins and a new truncated form of SPLUNC1 in nasopharyngeal aspirates from infants with respiratory syncytial virus infection. Proteomics Clin Appl 5 513-22 PubMed GONUTS page

[PMID:9727055-2] 2.0 ^2.1 ^2.2 Bals, R et al. (1998) Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102 874-80 PubMed GONUTS page

[PMID:21093056-3] 3.0 ^3.1 ^3.2 Huang, P et al. (2011) Characterization and expression of HLysG2, a basic goose-type lysozyme from the human eye and testis. Mol. Immunol. 48 524-31 PubMed GONUTS page

[PMID:23533145-4] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19199708-5] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:19056867-6] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:16502470-7] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:23580065-8] 8.0 ^8.1 Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:22664934-9] Böhm, D et al. (2012) Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Oncol. Rep. 28 429-38 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23353684-11] Wyatt, AR et al. (2013) Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms. FEBS Lett. 587 398-403 PubMed GONUTS page

[PMID:366724-12] Reitamo, S et al. () Human lysozyme (origin and distribution in health and disease). Ric Clin Lab 8 211-31 PubMed GONUTS page

[PMID:2829884-13] 13.0 ^13.1 Yoshimura, K et al. (1988) Human lysozyme: sequencing of a cDNA, and expression and secretion by Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 150 794-801 PubMed GONUTS page

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HUMAN:LYSC

Contents

Annotations

Notes

References

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