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PMID:366724

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Citation

Reitamo, S, Klockars, M, Adinolfi, M and Osserman, EF Human lysozyme (origin and distribution in health and disease). Ric Clin Lab 8:211-31

Abstract

Histochemical and in particular immunoperoxidase techniques have extended our knowledge about the cellular distribution of LZM. The enzyme has been detected in: 1. granulocytes, which synthesize LZM in bone marrow; 2. cells of the mononuclear phagocytic system, which synthesize LZM continuously; 3. various exocrine glands, whose LZM is probably in part synthesized locally and in part derived from blood; 4. cartilage, which probably synthesizes LZM and 5. the kidney, in which LZM is serum-derived. In pathological conditions, such as inflammation and neoplasia, most LZM-positive cells at the site of disease are either granulocytes or members of the mono-nuclear phagocytic system. A notable exception are the metaplastic Paneth cells that occur along the gastrointestinal tract in inflammation and neoplasia. LZM is an antibacterial agent, but evidence is accumulating which suggests that the enzyme might have other functions as well.

Links

PubMed

Keywords

Animals; Breast/enzymology; Cartilage/enzymology; Ear, Middle/enzymology; Exocrine Glands/enzymology; Female; Fetus/enzymology; Granulocytes/enzymology; Histocytochemistry; Humans; Immunoenzyme Techniques; Inflammation/enzymology; Intestinal Mucosa/enzymology; Kidney/enzymology; Lactation; Male; Monocytes/enzymology; Muramidase/biosynthesis; Muramidase/metabolism; Myeloproliferative Disorders/enzymology; Neoplasms/enzymology; Pregnancy; Respiratory System/enzymology; Salivary Glands/enzymology; Semen/enzymology; Skin/enzymology; Stomach/enzymology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:LYSC

involved_in

GO:0006954: inflammatory response

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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