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HUMAN:LYPA1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LYPLA1 (synonyms: APT1, LPL1) | |
| Protein Name(s) | Acyl-protein thioesterase 1
APT-1 hAPT1 Lysophospholipase 1 Lysophospholipase I LPL-I LysoPLA I | |
| External Links | ||
| UniProt | O75608 | |
| EMBL | AF081281 AF291053 AF077198 AF077199 BC008652 BC010397 AF035293 | |
| CCDS | CCDS6157.1 CCDS64899.1 | |
| RefSeq | NP_001266285.1 NP_001266286.1 NP_001266287.1 NP_001266288.1 NP_001266289.1 NP_006321.1 | |
| UniGene | Hs.744046 | |
| PDB | 1FJ2 | |
| PDBsum | 1FJ2 | |
| ProteinModelPortal | O75608 | |
| SMR | O75608 | |
| BioGrid | 115701 | |
| IntAct | O75608 | |
| MINT | MINT-5005801 | |
| STRING | 9606.ENSP00000320043 | |
| BindingDB | O75608 | |
| ChEMBL | CHEMBL1681631 | |
| MEROPS | S09.026 | |
| PhosphoSite | O75608 | |
| OGP | O75608 | |
| MaxQB | O75608 | |
| PaxDb | O75608 | |
| PeptideAtlas | O75608 | |
| PRIDE | O75608 | |
| DNASU | 10434 | |
| Ensembl | ENST00000316963 ENST00000343231 | |
| GeneID | 10434 | |
| KEGG | hsa:10434 | |
| UCSC | uc003xry.3 uc003xrz.3 | |
| CTD | 10434 | |
| GeneCards | GC08M055008 | |
| HGNC | HGNC:6737 | |
| HPA | HPA050941 | |
| MIM | 605599 | |
| neXtProt | NX_O75608 | |
| PharmGKB | PA30499 | |
| eggNOG | COG0400 | |
| GeneTree | ENSGT00390000009648 | |
| HOGENOM | HOG000260139 | |
| HOVERGEN | HBG052378 | |
| InParanoid | O75608 | |
| KO | K06128 | |
| OMA | FSQGPIN | |
| OrthoDB | EOG7M0NSQ | |
| PhylomeDB | O75608 | |
| TreeFam | TF314619 | |
| Reactome | REACT_12477 | |
| ChiTaRS | LYPLA1 | |
| EvolutionaryTrace | O75608 | |
| GeneWiki | LYPLA1 | |
| GenomeRNAi | 10434 | |
| NextBio | 39546 | |
| PRO | PR:O75608 | |
| Proteomes | UP000005640 | |
| Bgee | O75608 | |
| CleanEx | HS_LYPLA1 | |
| ExpressionAtlas | O75608 | |
| Genevestigator | O75608 | |
| GO | GO:0005829 GO:0070062 GO:0005739 GO:0004622 GO:0008474 GO:0006631 GO:0042997 GO:0046209 GO:0002084 GO:0050999 GO:0044281 | |
| Gene3D | 3.40.50.1820 | |
| InterPro | IPR029058 IPR003140 | |
| Pfam | PF02230 | |
| SUPFAM | SSF53474 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0016298 |
lipase activity |
ECO:0000314 |
F |
Figure 5 shows that treatment with an APT1 specific inhibitor, the laninamivir octanoate-hydrolyzing activity of the protein for peak II (APT1) is severely inhibited. |
complete | |||||
|
enables |
GO:0016298 |
lipase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008474 |
palmitoyl-(protein) hydrolase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0052689 |
carboxylic ester hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0042138 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008474 |
palmitoyl-(protein) hydrolase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344588 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0042138 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002084 |
protein depalmitoylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1344588 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042997 |
negative regulation of Golgi to plasma membrane protein transport |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97823 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008474 |
palmitoyl-(protein) hydrolase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97823 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97823 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0002084 |
protein depalmitoylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P97823 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004622 |
lysophospholipase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050999 |
regulation of nitric-oxide synthase activity |
Reactome:R-HSA-203615 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-203613 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006631 |
fatty acid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Koyama, K et al. (2014) Identification of bioactivating enzymes involved in the hydrolysis of laninamivir octanoate, a long-acting neuraminidase inhibitor, in human pulmonary tissue. Drug Metab. Dispos. 42 1031-8 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Dekker, FJ et al. (2010) Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat. Chem. Biol. 6 449-56 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Wang, A et al. (1999) A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. Biochim. Biophys. Acta 1437 157-69 PubMed GONUTS page
