HUMAN:LYAM1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SELL (synonyms: LNHR, LYAM1)
Protein Name(s)	L-selectin CD62 antigen-like family member L Leukocyte adhesion molecule 1 LAM-1 Leukocyte surface antigen Leu-8 Leukocyte-endothelial cell adhesion molecule 1 LECAM1 Lymph node homing receptor TQ1 gp90-MEL
External Links
UniProt	P14151
EMBL	M25280 X16150 X17519 X17519 X16070 M32414 M32406 M32407 M32408 M32409 M32410 M32411 M32412 M32413 AJ246000 AK312673 AY233976 AL021940 CH471067
CCDS	CCDS53427.1
RefSeq	NP_000646.2
UniGene	Hs.728756
PDB	1KJB 2LGF 3CFW
PDBsum	1KJB 2LGF 3CFW
ProteinModelPortal	P14151
SMR	P14151
BioGrid	112302
STRING	9606.ENSP00000236147
BindingDB	P14151
ChEMBL	CHEMBL3161
PhosphoSite	P14151
UniCarbKB	P14151
DMDM	126178
MaxQB	P14151
PaxDb	P14151
PRIDE	P14151
DNASU	6402
Ensembl	ENST00000236147
GeneID	6402
KEGG	hsa:6402
UCSC	uc001ggk.3 uc010pls.2
CTD	6402
GeneCards	GC01M169659
HGNC	HGNC:10720
HPA	CAB002144
MIM	153240
neXtProt	NX_P14151
Orphanet	34145
PharmGKB	PA35642
eggNOG	NOG258998
GeneTree	ENSGT00760000119425
HOGENOM	HOG000236254
HOVERGEN	HBG052375
InParanoid	P14151
KO	K06495
OMA	TDCWTYH
OrthoDB	EOG7DZ8J9
PhylomeDB	P14151
TreeFam	TF326910
Reactome	REACT_11152 REACT_12051
EvolutionaryTrace	P14151
GeneWiki	L-selectin
GenomeRNAi	6402
NextBio	24874
PMAP-CutDB	P14151
PRO	PR:P14151
Proteomes	UP000005640
Bgee	P14151
CleanEx	HS_SELL
ExpressionAtlas	P14151
Genevestigator	P14151
GO	GO:0009897 GO:0005887 GO:0005886 GO:0030246 GO:0043208 GO:0008201 GO:0002020 GO:0007596 GO:0007155 GO:0050900 GO:0050776 GO:0033198
Gene3D	3.10.100.10
InterPro	IPR001304 IPR016186 IPR018378 IPR016187 IPR000742 IPR013032 IPR016348 IPR002396 IPR000436
Pfam	PF00008 PF00059 PF00084
PIRSF	PIRSF002421
PRINTS	PR00343
SMART	SM00032 SM00034 SM00181
SUPFAM	SSF56436 SSF57535
PROSITE	PS00615 PS50041 PS00022 PS01186 PS50026 PS50923

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0070492	oligosaccharide binding	PMID:28011641^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:28011641^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0050901	leukocyte tethering or rolling	PMID:28011641^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	PMID:28011641^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005509	calcium ion binding	PMID:28011641^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2663882^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:17548643^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P78325	F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002396 InterPro:IPR016348	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002396	C	Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016348	P	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	PMID:10747985^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:10747985^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:1692315^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:1692315^[5] PMID:10882119^[6] Reactome:R-HSA-6798743 Reactome:R-HSA-202724 Reactome:R-HSA-199046	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043208	glycosphingolipid binding	PMID:7680663^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:7680663^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050900	leukocyte migration	Reactome:R-HSA-202733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	Reactome:R-HSA-198933	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0130	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0430	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Mehta-D'souza, P et al. (2017) Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J. Biol. Chem. 292 2510-2518 PubMed GONUTS page
↑ Bowen, BR et al. (1989) Characterization of a human homologue of the murine peripheral lymph node homing receptor. J. Cell Biol. 109 421-7 PubMed GONUTS page
↑ Gómez-Gaviro, M et al. (2007) Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J. Immunol. 178 8053-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Dwir, O et al. (2000) An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow. J. Biol. Chem. 275 18682-91 PubMed GONUTS page
↑ ^5.0 ^5.1 Ord, DC et al. (1990) Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. J. Biol. Chem. 265 7760-7 PubMed GONUTS page
↑ Walther, A et al. (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol. Cell 5 831-40 PubMed GONUTS page
↑ ^7.0 ^7.1 Nelson, RM et al. (1993) Higher-affinity oligosaccharide ligands for E-selectin. J. Clin. Invest. 91 1157-66 PubMed GONUTS page

[PMID:28011641-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Mehta-D'souza, P et al. (2017) Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J. Biol. Chem. 292 2510-2518 PubMed GONUTS page

[PMID:2663882-2] Bowen, BR et al. (1989) Characterization of a human homologue of the murine peripheral lymph node homing receptor. J. Cell Biol. 109 421-7 PubMed GONUTS page

[PMID:17548643-3] Gómez-Gaviro, M et al. (2007) Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J. Immunol. 178 8053-63 PubMed GONUTS page

[PMID:10747985-4] 4.0 ^4.1 Dwir, O et al. (2000) An activated L-selectin mutant with conserved equilibrium binding properties but enhanced ligand recognition under shear flow. J. Biol. Chem. 275 18682-91 PubMed GONUTS page

[PMID:1692315-5] 5.0 ^5.1 Ord, DC et al. (1990) Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils. J. Biol. Chem. 265 7760-7 PubMed GONUTS page

[PMID:10882119-6] Walther, A et al. (2000) A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol. Cell 5 831-40 PubMed GONUTS page

[PMID:7680663-7] 7.0 ^7.1 Nelson, RM et al. (1993) Higher-affinity oligosaccharide ligands for E-selectin. J. Clin. Invest. 91 1157-66 PubMed GONUTS page

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HUMAN:LYAM1

Contents

Annotations

Notes

References

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