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HUMAN:LRP8
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LRP8 (synonyms: APOER2) | |
| Protein Name(s) | Low-density lipoprotein receptor-related protein 8
LRP-8 Apolipoprotein E receptor 2 | |
| External Links | ||
| UniProt | Q14114 | |
| EMBL | D50678 D86407 D86407 Z75190 AL606760 AL355483 AL606760 AL355483 AL355483 AL606760 AL606760 AL355483 AL355483 AL606760 AL355483 AL606760 BC006443 BC051836 | |
| CCDS | CCDS30720.1 CCDS578.1 CCDS579.1 CCDS580.1 | |
| RefSeq | NP_001018064.1 NP_004622.2 NP_059992.3 NP_150643.2 | |
| UniGene | Hs.280387 | |
| PDB | 3A7Q | |
| PDBsum | 3A7Q | |
| ProteinModelPortal | Q14114 | |
| SMR | Q14114 | |
| BioGrid | 113579 | |
| DIP | DIP-48670N | |
| IntAct | Q14114 | |
| STRING | 9606.ENSP00000303634 | |
| PhosphoSite | Q14114 | |
| DMDM | 259016389 | |
| MaxQB | Q14114 | |
| PaxDb | Q14114 | |
| PRIDE | Q14114 | |
| Ensembl | ENST00000306052 ENST00000347547 ENST00000354412 ENST00000371454 | |
| GeneID | 7804 | |
| KEGG | hsa:7804 | |
| UCSC | uc001cvi.2 uc001cvj.2 uc001cvk.2 uc001cvl.2 | |
| CTD | 7804 | |
| GeneCards | GC01M053711 | |
| HGNC | HGNC:6700 | |
| MIM | 602600 608446 | |
| neXtProt | NX_Q14114 | |
| PharmGKB | PA30457 | |
| eggNOG | NOG255913 | |
| GeneTree | ENSGT00760000118968 | |
| HOVERGEN | HBG006250 | |
| InParanoid | Q14114 | |
| OMA | YWCDLFY | |
| OrthoDB | EOG7NGQ9P | |
| PhylomeDB | Q14114 | |
| TreeFam | TF351700 | |
| Reactome | REACT_23879 REACT_24968 | |
| ChiTaRS | LRP8 | |
| EvolutionaryTrace | Q14114 | |
| GeneWiki | Low_density_lipoprotein_receptor-related_protein_8 | |
| GenomeRNAi | 7804 | |
| NextBio | 30188 | |
| PMAP-CutDB | B1AMT8 | |
| PRO | PR:Q14114 | |
| Proteomes | UP000005640 | |
| Bgee | Q14114 | |
| CleanEx | HS_LRP8 | |
| ExpressionAtlas | Q14114 | |
| Genevestigator | Q14114 | |
| GO | GO:0030424 GO:0005901 GO:0030425 GO:0005576 GO:0016021 GO:0016020 GO:0005875 GO:0043025 GO:0005886 GO:0014069 GO:0043235 GO:0034185 GO:0005509 GO:0008035 GO:0038025 GO:0004888 GO:0030229 GO:0021541 GO:0007596 GO:0071397 GO:0071363 GO:0019221 GO:0006897 GO:0021819 GO:0006629 GO:0000122 GO:0007603 GO:0032793 GO:1900006 GO:0061003 GO:0050731 GO:0061098 GO:0006508 GO:0006898 GO:0038026 GO:0050804 GO:0042493 GO:0001523 GO:0007165 | |
| Gene3D | 2.120.10.30 4.10.400.10 | |
| InterPro | IPR011042 IPR000742 IPR001881 IPR013032 IPR000152 IPR018097 IPR023415 IPR000033 IPR002172 | |
| Pfam | PF07645 PF00057 PF00058 | |
| PRINTS | PR00261 | |
| SMART | SM00181 SM00179 SM00192 SM00135 | |
| SUPFAM | SSF57424 | |
| PROSITE | PS00010 PS01186 PS50026 PS01187 PS01209 PS50068 PS51120 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0045088 |
regulation of innate immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000303 |
author statement without traceable support used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1900006 |
positive regulation of dendrite development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061098 |
positive regulation of protein tyrosine kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0061003 |
positive regulation of dendritic spine morphogenesis |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038026 |
reelin-mediated signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0038025 |
reelin receptor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0034185 |
apolipoprotein binding |
ECO:0000305 |
curator inference used in manual assertion |
GO:0030229 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032793 |
positive regulation of CREB transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0030229 |
very-low-density lipoprotein particle receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0021541 |
ammon gyrus development |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005901 |
caveola |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000122 |
negative regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000305 |
curator inference used in manual assertion |
GO:0030229 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0071397 |
cellular response to cholesterol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071363 |
cellular response to growth factor stimulus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043025 |
neuronal cell body |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042493 |
response to drug |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030425 |
dendrite |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030424 |
axon |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0021987 |
cerebral cortex development |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019894 |
kinesin binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0014069 |
postsynaptic density |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0008035 |
high-density lipoprotein particle binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005875 |
microtubule associated complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:D3ZE75 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005041 |
low-density lipoprotein particle receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006629 |
lipid metabolic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004888 |
transmembrane signaling receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8948034 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001523 |
retinoid metabolic process |
Reactome:R-HSA-975634 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 2.0 2.1 Trommsdorff, M et al. (1999) Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell 97 689-701 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 Kim, DH et al. (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. J. Biol. Chem. 271 8373-80 PubMed GONUTS page
- ↑ Riddell, DR et al. (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J. Lipid Res. 42 998-1002 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Korschineck, I et al. (2001) Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue. J. Biol. Chem. 276 13192-7 PubMed GONUTS page
- ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
- ↑ Kim, J et al. (2009) Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance. Neuron 64 632-44 PubMed GONUTS page
c
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- GO:0005886 ! plasma membrane
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:1900006 ! positive regulation of dendrite development
- GO:0061098 ! positive regulation of protein tyrosine kinase activity
- GO:0061003 ! positive regulation of dendritic spine morphogenesis
- GO:0032793 ! positive regulation of CREB transcription factor activity
- GO:0014069 ! postsynaptic density
- Primates
- GO:0006508 ! proteolysis
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