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HUMAN:LOXL1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LOXL1 (synonyms: LOXL)
Protein Name(s) Lysyl oxidase homolog 1

Lysyl oxidase-like protein 1 LOL

External Links
UniProt Q08397
EMBL L21186
U24389
U24395
U24394
U24393
U24391
U24390
AK314222
AC108137
BC015090
BC068542
CCDS CCDS10253.1
PIR A48501
RefSeq NP_005567.2
UniGene Hs.65436
ProteinModelPortal Q08397
BioGrid 110200
IntAct Q08397
STRING 9606.ENSP00000261921
PhosphoSite Q08397
DMDM 189031484
PaxDb Q08397
PRIDE Q08397
DNASU 4016
Ensembl ENST00000261921
GeneID 4016
KEGG hsa:4016
UCSC uc002awc.1
CTD 4016
GeneCards GC15P074218
HGNC HGNC:6665
HPA HPA042111
MIM 153456
177650
neXtProt NX_Q08397
PharmGKB PA30428
eggNOG NOG77510
GeneTree ENSGT00760000119251
HOGENOM HOG000234262
HOVERGEN HBG000226
InParanoid Q08397
KO K14678
OMA QGYVYYR
OrthoDB EOG7SN8C6
PhylomeDB Q08397
TreeFam TF326061
Reactome REACT_150206
REACT_150366
ChiTaRS LOXL1
GeneWiki LOXL1
GenomeRNAi 4016
NextBio 15756
PRO PR:Q08397
Proteomes UP000005640
Bgee Q08397
CleanEx HS_LOXL1
ExpressionAtlas Q08397
Genevestigator Q08397
GO GO:0001669
GO:0005604
GO:0005576
GO:0005615
GO:0005507
GO:0016641
GO:0035904
GO:0030198
GO:0055114
GO:0018277
GO:0032496
InterPro IPR001695
IPR019828
Pfam PF01186
PRINTS PR00074
PROSITE PS00926

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 4 shows Proliferation marker Ki-67 is decreased by rLOX-PP treatment.

complete
CACAO 6272

GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 5 shows Proliferation marker phosphorylated histone H3 is decreased by rLOX-PP treatment.

complete
CACAO 6274

GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 6 shows Apoptosis marker active caspase 3 is increased by rLOX-PP treatment.

complete
CACAO 6275

GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 7 shows Apoptosis marker TUNEL is increased by rLOX-PP treatment.

complete
CACAO 6276

GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 8 shows rLOX-PP persists in treated tumors

complete
CACAO 6277

GO:0006915

apoptotic process

PMID:22363577[1]

ECO:0000314

P

Figure 9 shows LOX-PP inhibits Ras effector Erk1/2 phosphorylation in vivo.

complete
CACAO 6281

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:28327460[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0002540)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:28675934[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0003688)

Seeded From UniProt

complete

part_of

GO:0062023

collagen-containing extracellular matrix

PMID:27068509[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0007318)

Seeded From UniProt

complete

colocalizes_with

GO:0062023

collagen-containing extracellular matrix

PMID:20551380[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001496)

Seeded From UniProt

complete

involved_in

GO:0018057

peptidyl-lysine oxidation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1337004
PANTHER:PTN001832947
UniProtKB:P58215
UniProtKB:Q9Y4K0

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1337004
PANTHER:PTN001832947
UniProtKB:Q9Y4K0

C

Seeded From UniProt

complete

enables

GO:0004720

protein-lysine 6-oxidase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1337004
MGI:MGI:1914823
MGI:MGI:96817
PANTHER:PTN001832947
RGD:3015
UniProtKB:P58215
UniProtKB:Q9Y4K0

F

Seeded From UniProt

complete

involved_in

GO:0035904

aorta development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

P

Seeded From UniProt

complete

part_of

GO:0031012

extracellular matrix

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

C

Seeded From UniProt

complete

part_of

GO:0005604

basement membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

C

Seeded From UniProt

complete

part_of

GO:0001669

acrosomal vesicle

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5FWS5
ensembl:ENSRNOP00000032184

C

Seeded From UniProt

complete

enables

GO:0005507

copper ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001695
InterPro:IPR019828

F

Seeded From UniProt

complete

enables

GO:0016641

oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001695
InterPro:IPR019828

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001695
InterPro:IPR019828

P

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

PMID:7689553[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018277

protein deamination

PMID:7689553[7]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:7689553[7]
Reactome:R-HSA-2395340
Reactome:R-HSA-2129375
Reactome:R-HSA-2022141
Reactome:R-HSA-2002466

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

involved_in

GO:0030198

extracellular matrix organization

Reactome:R-HSA-1474244

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964

C

Seeded From UniProt

complete

enables

GO:0016491

oxidoreductase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

F

Seeded From UniProt

complete

involved_in

GO:0055114

oxidation-reduction process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0560

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0112

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Bais, MV et al. (2012) Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. PLoS ONE 7 e31188 PubMed GONUTS page
  2. ↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
  3. ↑ Naba, A et al. (2017) Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics. J. Proteome Res. 16 3083-3091 PubMed GONUTS page
  4. ↑ Barallobre-Barreiro, J et al. (2016) Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Cardiovasc. Res. 110 419-30 PubMed GONUTS page
  5. ↑ Didangelos, A et al. (2010) Proteomics characterization of extracellular space components in the human aorta. Mol. Cell Proteomics 9 2048-62 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Kenyon, K et al. (1993) A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25. J. Biol. Chem. 268 18435-7 PubMed GONUTS page
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