HUMAN:LIPP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PNLIP
Protein Name(s)	Pancreatic triacylglycerol lipase PL PTL Pancreatic lipase
External Links
UniProt	P16233
EMBL	J05125 M93285 L24529 L11242 L24502 L24522 L24523 L24525 L24526 L24527 L24528 AK313941 AL731653 CH471066 BC014309
CCDS	CCDS7594.1
PIR	C43357
RefSeq	NP_000927.1
UniGene	Hs.501135
PDB	1LPA 1LPB 1N8S
PDBsum	1LPA 1LPB 1N8S
ProteinModelPortal	P16233
SMR	P16233
BioGrid	111407
IntAct	P16233
MINT	MINT-1179407
STRING	9606.ENSP00000358223
BindingDB	P16233
ChEMBL	CHEMBL1812
DrugBank	DB08909 DB01083
GuidetoPHARMACOLOGY	2590
PhosphoSite	P16233
DMDM	126318
PaxDb	P16233
PRIDE	P16233
Ensembl	ENST00000369221
GeneID	5406
KEGG	hsa:5406
UCSC	uc001lcm.3
CTD	5406
GeneCards	GC10P118305
HGNC	HGNC:9155
MIM	246600
neXtProt	NX_P16233
PharmGKB	PA33478
eggNOG	NOG40923
GeneTree	ENSGT00760000119069
HOGENOM	HOG000038552
HOVERGEN	HBG003243
InParanoid	P16233
KO	K14073
OMA	MSQVVGH
OrthoDB	EOG7KSX8B
PhylomeDB	P16233
TreeFam	TF324997
BioCyc	MetaCyc:HS10947-MONOMER
Reactome	REACT_24968 REACT_9518
SABIO-RK	P16233
ChiTaRS	PNLIP
EvolutionaryTrace	P16233
GeneWiki	Pancreatic_lipase
GenomeRNAi	5406
NextBio	20931
PRO	PR:P16233
Proteomes	UP000005640
Bgee	P16233
CleanEx	HS_PNLIP
Genevestigator	P16233
GO	GO:0005576 GO:0046872 GO:0004806 GO:0030299 GO:0016042 GO:0044241 GO:0007603 GO:0001523 GO:0044281
Gene3D	2.60.60.20 3.40.50.1820
InterPro	IPR029058 IPR016272 IPR008976 IPR013818 IPR002331 IPR001024 IPR000734
PANTHER	PTHR11610
Pfam	PF00151 PF01477
PIRSF	PIRSF000865
PRINTS	PR00823 PR00821
SMART	SM00308
SUPFAM	SSF49723 SSF53474
PROSITE	PS00120 PS50095

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004806	triglyceride lipase activity	PMID:9631512	ECO:0000314			F		Figure 1	complete CACAO 5376
	GO:0061365	triglyceride lipase activity	PMID:9631512	ECO:0000314			F		Figure 1	complete CACAO 5493
part_of	GO:0005615	extracellular space		ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0016298	lipase activity		ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process		ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6P8U6	F		Seeded From UniProt	complete
involved_in	GO:0061365	positive regulation of triglyceride lipase activity	PMID:9631512	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030299	intestinal cholesterol absorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P8U6 ensembl:ENSMUSP00000056377	P		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6P8U6 ensembl:ENSMUSP00000056377	F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002331	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002331 InterPro:IPR016272 InterPro:IPR033906	P		Seeded From UniProt	complete
enables	GO:0052689	carboxylic ester hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000734 InterPro:IPR016272	F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.1.1.3	F		Seeded From UniProt	complete
enables	GO:0004806	triglyceride lipase activity	PMID:1783385	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0044241	lipid digestion	Reactome:R-HSA-192456	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-975593 Reactome:R-HSA-192434 Reactome:R-HSA-192422	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001523	retinoid metabolic process	Reactome:R-HSA-975634	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0016042	lipid catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0442	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
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References

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