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HUMAN:LIFR
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | LIFR | |
| Protein Name(s) | Leukemia inhibitory factor receptor
LIF receptor LIF-R | |
| External Links | ||
| UniProt | P42702 | |
| EMBL | X61615 U66563 | |
| CCDS | CCDS3927.1 | |
| PIR | S17308 | |
| RefSeq | NP_001121143.1 NP_002301.1 | |
| UniGene | Hs.133421 | |
| PDB | 3E0G | |
| PDBsum | 3E0G | |
| ProteinModelPortal | P42702 | |
| SMR | P42702 | |
| BioGrid | 110165 | |
| DIP | DIP-5770N | |
| MINT | MINT-1352123 | |
| STRING | 9606.ENSP00000263409 | |
| ChEMBL | CHEMBL3137274 | |
| PhosphoSite | P42702 | |
| DMDM | 1170784 | |
| MaxQB | P42702 | |
| PaxDb | P42702 | |
| PRIDE | P42702 | |
| DNASU | 3977 | |
| Ensembl | ENST00000263409 ENST00000453190 | |
| GeneID | 3977 | |
| KEGG | hsa:3977 | |
| UCSC | uc003jli.2 | |
| CTD | 3977 | |
| GeneCards | GC05M038475 | |
| HGNC | HGNC:6597 | |
| HPA | CAB010252 HPA004478 | |
| MIM | 151443 601559 | |
| neXtProt | NX_P42702 | |
| Orphanet | 3206 | |
| PharmGKB | PA30371 | |
| eggNOG | NOG147644 | |
| GeneTree | ENSGT00550000074436 | |
| HOGENOM | HOG000113324 | |
| HOVERGEN | HBG006266 | |
| InParanoid | P42702 | |
| KO | K05058 | |
| OMA | FYPDIPN | |
| OrthoDB | EOG7V49XP | |
| PhylomeDB | P42702 | |
| TreeFam | TF338122 | |
| SignaLink | P42702 | |
| ChiTaRS | LIFR | |
| EvolutionaryTrace | P42702 | |
| GeneWiki | Leukemia_inhibitory_factor_receptor | |
| GenomeRNAi | 3977 | |
| NextBio | 15588 | |
| PRO | PR:P42702 | |
| Proteomes | UP000005640 | |
| Bgee | P42702 | |
| CleanEx | HS_LIFR | |
| ExpressionAtlas | P42702 | |
| Genevestigator | P42702 | |
| GO | GO:0070062 GO:0005887 GO:0043235 GO:0005127 GO:0019838 GO:0004923 GO:0007166 GO:0070120 GO:0019221 GO:0048861 GO:0038165 GO:0008284 GO:0034097 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR003529 IPR013783 | |
| Pfam | PF00041 | |
| SMART | SM00060 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 PS01353 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0038165 |
oncostatin-M-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070120 |
ciliary neurotrophic factor-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048861 |
leukemia inhibitory factor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048861 |
leukemia inhibitory factor signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034097 |
response to cytokine |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0019838 |
growth factor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005127 |
ciliary neurotrophic factor receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004924 |
oncostatin-M receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004923 |
leukemia inhibitory factor receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004923 |
leukemia inhibitory factor receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0004897 |
ciliary neurotrophic factor receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019955 |
cytokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96788 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005127 |
ciliary neurotrophic factor receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000547941 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004924 |
oncostatin-M receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330819 |
F |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0004923 |
leukemia inhibitory factor receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000547941 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004923 |
leukemia inhibitory factor receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:P42703 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007166 |
cell surface receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005887 |
integral component of plasma membrane |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004923 |
leukemia inhibitory factor receptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6783589 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8934690 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0001959 |
regulation of cytokine-mediated signaling pathway |
Reactome:R-HSA-8939247 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Mosley, B et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation. J. Biol. Chem. 271 32635-43 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 Schuster, B et al. (2003) Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF. J. Biol. Chem. 278 9528-35 PubMed GONUTS page
- ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
- ↑ Man, D et al. (2003) Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J. Biol. Chem. 278 23285-94 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Hilton, DJ et al. (1994) Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. EMBO J. 13 4765-75 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 Gearing, DP et al. (1991) Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130. EMBO J. 10 2839-48 PubMed GONUTS page
c
- Catarrhini
- GO:0007166 ! cell surface receptor signaling pathway
- Chordata
- GO:0070120 ! ciliary neurotrophic factor-mediated signaling pathway
- GO:0005127 ! ciliary neurotrophic factor receptor binding
- GO:0004897 ! ciliary neurotrophic factor receptor activity
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0019955 ! cytokine binding
- GO:0004896 ! cytokine receptor activity
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