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HUMAN:LEO1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LEO1 (synonyms: RDL)
Protein Name(s) RNA polymerase-associated protein LEO1

Replicative senescence down-regulated leo1-like protein

External Links
UniProt Q8WVC0
EMBL AY302186
AK055762
BC018147
CCDS CCDS10146.1
CCDS66767.1
RefSeq NP_001273359.1
NP_620147.1
UniGene Hs.567662
PDB 4M6T
PDBsum 4M6T
ProteinModelPortal Q8WVC0
SMR Q8WVC0
BioGrid 125817
DIP DIP-37885N
IntAct Q8WVC0
STRING 9606.ENSP00000299601
PhosphoSite Q8WVC0
DMDM 74751545
MaxQB Q8WVC0
PaxDb Q8WVC0
PeptideAtlas Q8WVC0
PRIDE Q8WVC0
Ensembl ENST00000299601
ENST00000315141
GeneID 123169
KEGG hsa:123169
UCSC uc002abo.3
uc010bfd.3
CTD 123169
GeneCards GC15M052230
HGNC HGNC:30401
HPA HPA040741
HPA040941
MIM 610507
neXtProt NX_Q8WVC0
PharmGKB PA142671558
eggNOG NOG130430
GeneTree ENSGT00550000074952
HOGENOM HOG000253934
HOVERGEN HBG081913
InParanoid Q8WVC0
KO K15177
OMA HEDNEPS
OrthoDB EOG7W41BG
PhylomeDB Q8WVC0
TreeFam TF321961
Reactome REACT_200753
ChiTaRS LEO1
GeneWiki LEO1
GenomeRNAi 123169
NextBio 81081
PRO PR:Q8WVC0
Proteomes UP000005640
Bgee Q8WVC0
CleanEx HS_LEO1
Genevestigator Q8WVC0
GO GO:0016593
GO:0001711
GO:0033523
GO:0010390
GO:0006378
GO:0045638
GO:0031442
GO:0032968
GO:0045944
GO:0019827
GO:0006351
GO:0016055
InterPro IPR007149
Pfam PF04004

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20178742[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045638

negative regulation of myeloid cell differentiation

PMID:20541477[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0033523

histone H2B ubiquitination

PMID:16307923[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:20178742[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031442

positive regulation of mRNA 3'-end processing

PMID:21329879[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019827

stem cell population maintenance

PMID:19345177[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:20178742[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:18987311[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

PMID:16307923[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010390

histone monoubiquitination

PMID:16307923[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006378

mRNA polyadenylation

PMID:21329879[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001711

endodermal cell fate commitment

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q5XJE5

P

Seeded From UniProt

complete

enables

GO:1990269

RNA polymerase II C-terminal domain phosphoserine binding

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000567381
SGD:S000005649

F

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000567381
SGD:S000005649
UniProtKB:Q8WVC0

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000567381
SGD:S000005649
UniProtKB:Q9FNQ0

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0019827

stem cell population maintenance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XJE5
ensembl:ENSMUSP00000046905

P

Seeded From UniProt

complete

involved_in

GO:0001711

endodermal cell fate commitment

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q5XJE5
ensembl:ENSMUSP00000046905

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007149

P

Seeded From UniProt

complete

involved_in

GO:0016570

histone modification

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007149

P

Seeded From UniProt

complete

part_of

GO:0016593

Cdc73/Paf1 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007149

C

Seeded From UniProt

complete

involved_in

GO:1904837

beta-catenin-TCF complex assembly

Reactome:R-HSA-201722

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

Reactome:R-HSA-8866654

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

Reactome:R-HSA-75955
Reactome:R-HSA-112382

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0006366

transcription by RNA polymerase II

Reactome:R-HSA-73857

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-8942101
Reactome:R-HSA-8942099
Reactome:R-HSA-3322424
Reactome:R-HSA-113429
Reactome:R-HSA-113414
Reactome:R-HSA-113413
Reactome:R-HSA-113412
Reactome:R-HSA-113411
Reactome:R-HSA-112396
Reactome:R-HSA-112395
Reactome:R-HSA-112392
Reactome:R-HSA-112385
Reactome:R-HSA-112379

ECO:0000304

author statement supported by traceable reference used in manual assertion













C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Kim, J et al. (2010) The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell 140 491-503 PubMed GONUTS page
  2. ↑ Muntean, AG et al. (2010) The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17 609-21 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Zhu, B et al. (2005) Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol. Cell 20 601-11 PubMed GONUTS page
  4. ↑ 4.0 4.1 Nagaike, T et al. (2011) Transcriptional activators enhance polyadenylation of mRNA precursors. Mol. Cell 41 409-18 PubMed GONUTS page
  5. ↑ Ding, L et al. (2009) A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell 4 403-15 PubMed GONUTS page
  6. ↑ Lin, L et al. (2008) The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene. Proc. Natl. Acad. Sci. U.S.A. 105 17420-5 PubMed GONUTS page
  7. ↑ 7.0 7.1 7.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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