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HUMAN:LCP2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LCP2
Protein Name(s) Lymphocyte cytosolic protein 2

SH2 domain-containing leukocyte protein of 76 kDa SLP-76 tyrosine phosphoprotein SLP76

External Links
UniProt Q13094
EMBL U20158
BT007273
AK292890
CH471062
BC016618
CCDS CCDS47339.1
PIR A56110
RefSeq NP_005556.1
UniGene Hs.304475
PDB 1H3H
1YWO
2EAP
2ROR
PDBsum 1H3H
1YWO
2EAP
2ROR
ProteinModelPortal Q13094
SMR Q13094
BioGrid 110129
DIP DIP-31812N
IntAct Q13094
MINT MINT-110432
STRING 9606.ENSP00000046794
PhosphoSite Q13094
DMDM 10720065
MaxQB Q13094
PaxDb Q13094
PRIDE Q13094
DNASU 3937
Ensembl ENST00000046794
GeneID 3937
KEGG hsa:3937
UCSC uc003man.1
CTD 3937
GeneCards GC05M169673
H-InvDB HIX0005402
HGNC HGNC:6529
HPA CAB004574
HPA036396
HPA036397
MIM 601603
neXtProt NX_Q13094
PharmGKB PA30313
eggNOG NOG43557
GeneTree ENSGT00530000063094
HOGENOM HOG000049173
HOVERGEN HBG006247
InParanoid Q13094
KO K07361
OMA NSMYIDR
OrthoDB EOG7FJH09
PhylomeDB Q13094
TreeFam TF326567
Reactome REACT_12623
REACT_147814
REACT_163701
REACT_163834
REACT_1695
SignaLink Q13094
EvolutionaryTrace Q13094
GeneWiki Lymphocyte_cytosolic_protein_2
GenomeRNAi 3937
NextBio 15461
PRO PR:Q13094
Proteomes UP000005640
Bgee Q13094
CleanEx HS_LCP2
ExpressionAtlas Q13094
Genevestigator Q13094
GO GO:0005911
GO:0005829
GO:0007596
GO:0050663
GO:0038095
GO:0006955
GO:0045087
GO:0045576
GO:0030168
GO:0050852
GO:0007169
Gene3D 1.10.150.50
3.30.505.10
InterPro IPR001660
IPR013761
IPR011510
IPR000980
Pfam PF07647
PF00017
SMART SM00454
SM00252
SUPFAM SSF47769
SSF55550
PROSITE PS50001

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0036398

TCR signalosome

PMID:20551903[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

PMID:20551903[1]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(GO:0001772)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:20551903[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0044853

plasma membrane raft

PMID:20551903[1]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

GO:0045860

positive regulation of protein kinase activity

PMID:14624253[2]

ECO:0000270

P

Figure 1, Fig 2BC, Fig 3CE

complete
CACAO 2118

involved_in

GO:0045860

positive regulation of protein kinase activity

PMID:14624253[2]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001019935
UniProtKB:Q7Z7G1
UniProtKB:Q8WV28

P

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1351468
PANTHER:PTN001019935

P

Seeded From UniProt

complete

involved_in

GO:0050663

cytokine secretion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60787
ensembl:ENSMUSP00000056621

P

Seeded From UniProt

complete

involved_in

GO:0045576

mast cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60787
ensembl:ENSMUSP00000056621

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q60787
ensembl:ENSMUSP00000056621

C

Seeded From UniProt

complete

involved_in

GO:0007169

transmembrane receptor protein tyrosine kinase signaling pathway

PMID:7706237[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:7706237[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

Reactome:R-HSA-202403

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:R-HSA-2454202

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030168

platelet activation

Reactome:R-HSA-76002

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-430190
Reactome:R-HSA-430183
Reactome:R-HSA-430180
Reactome:R-HSA-430158
Reactome:R-HSA-430135
Reactome:R-HSA-429449
Reactome:R-HSA-2730892
Reactome:R-HSA-2730889
Reactome:R-HSA-2730858
Reactome:R-HSA-2730856
Reactome:R-HSA-2730851
Reactome:R-HSA-2730847
Reactome:R-HSA-2730841
Reactome:R-HSA-2730840
Reactome:R-HSA-2730833
Reactome:R-HSA-2424487
Reactome:R-HSA-2424486
Reactome:R-HSA-2424485
Reactome:R-HSA-2424484
Reactome:R-HSA-2424481
Reactome:R-HSA-2424476
Reactome:R-HSA-2396606
Reactome:R-HSA-2396594
Reactome:R-HSA-2396561
Reactome:R-HSA-213407
Reactome:R-HSA-202375
Reactome:R-HSA-202331
Reactome:R-HSA-202248
Reactome:R-HSA-202241
Reactome:R-HSA-202216

ECO:0000304

author statement supported by traceable reference used in manual assertion






























C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 Lasserre, R et al. (2010) Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapse. EMBO J. 29 2301-14 PubMed GONUTS page
  2. ↑ 2.0 2.1 Roose, JP et al. (2003) T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 1 E53 PubMed GONUTS page
  3. ↑ 3.0 3.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Jackman, JK et al. (1995) Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells. J. Biol. Chem. 270 7029-32 PubMed GONUTS page
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