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HUMAN:LAT

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LAT
Protein Name(s) Linker for activation of T-cells family member 1

36 kDa phospho-tyrosine adapter protein pp36 p36-38

External Links
UniProt O43561
EMBL AF036906
AF036905
AJ223280
FN432832
AC109460
CH471267
CH471267
BC011563
CCDS CCDS10647.1
CCDS32425.1
CCDS45455.1
CCDS53999.1
RefSeq NP_001014987.1
NP_001014988.1
NP_001014989.2
NP_055202.1
UniGene Hs.632179
ProteinModelPortal O43561
BioGrid 117971
DIP DIP-29231N
IntAct O43561
MINT MINT-2836977
STRING 9606.ENSP00000354119
ChEMBL CHEMBL5779
PhosphoSite O43561
MaxQB O43561
PaxDb O43561
PRIDE O43561
Ensembl ENST00000360872
ENST00000395456
ENST00000395461
ENST00000454369
ENST00000564277
ENST00000566177
GeneID 27040
KEGG hsa:27040
UCSC uc002dsb.3
uc002dsc.3
uc002dsd.3
uc010vdj.2
CTD 27040
GeneCards GC16P028998
HGNC HGNC:18874
HPA CAB002223
CAB012978
HPA011157
MIM 602354
neXtProt NX_O43561
PharmGKB PA38728
eggNOG NOG41822
GeneTree ENSGT00390000014223
HOGENOM HOG000081810
HOVERGEN HBG018198
InParanoid O43561
KO K07362
OMA SYENEGI
PhylomeDB O43561
Reactome REACT_12623
REACT_147814
REACT_163701
REACT_163834
REACT_163936
REACT_1695
SignaLink O43561
GeneWiki Linker_of_activated_T_cells
GenomeRNAi 27040
NextBio 35483432
PRO PR:O43561
Proteomes UP000005640
Bgee O43561
CleanEx HS_LAT
ExpressionAtlas O43561
Genevestigator O43561
GO GO:0005911
GO:0008180
GO:0001772
GO:0016021
GO:0042629
GO:0045121
GO:0005886
GO:0019901
GO:0005070
GO:0007596
GO:0019722
GO:0038095
GO:0010467
GO:0006955
GO:0006954
GO:0045087
GO:0007229
GO:0035556
GO:0002260
GO:0043303
GO:0030168
GO:0009967
GO:0007265
GO:0050863
GO:0042110
GO:0050852
InterPro IPR008359
PANTHER PTHR15586
Pfam PF15234
PRINTS PR01781

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0045860

positive regulation of protein kinase activity

PMID:14624253[1]

ECO:0000270

P

Figure 1, 2BC, and Fig. 3C-E. Figure 3 in particular indicates that "proper localization and signaling through the adapter LAT are required for normal suppression of RAG gene expression".

complete
CACAO 2120

involved_in

GO:0045860

positive regulation of protein kinase activity

PMID:14624253[1]

ECO:0000270

expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050863

regulation of T cell activation

PMID:12646565[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:12646565[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019722

calcium-mediated signaling

PMID:12646565[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:12646565[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007265

Ras protein signal transduction

PMID:12646565[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007229

integrin-mediated signaling pathway

PMID:15100278[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:15100278[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005070

SH3/SH2 adaptor activity

PMID:9489702[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0001772

immunological synapse

PMID:12646565[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:12186560[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q08881

F

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O54957

C

Seeded From UniProt

complete

involved_in

GO:0050863

regulation of T cell activation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000400392
UniProtKB:O43561

P

Seeded From UniProt

complete

involved_in

GO:0045860

positive regulation of protein kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000400392
UniProtKB:O43561

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000400392
UniProtKB:O43561

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000400392
UniProtKB:O43561

F

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000400392
UniProtKB:O43561

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342293
PANTHER:PTN000400392

P

Seeded From UniProt

complete

part_of

GO:0001772

immunological synapse

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1342293
PANTHER:PTN000400392
UniProtKB:O43561

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0009967

positive regulation of signal transduction

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005070

P

Seeded From UniProt

complete

part_of

GO:0042629

mast cell granule

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0043303

C

Seeded From UniProt

complete

involved_in

GO:0048872

homeostasis of number of cells

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

P

Seeded From UniProt

complete

involved_in

GO:0010467

gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

P

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

P

Seeded From UniProt

complete

part_of

GO:0005911

cell-cell junction

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

C

Seeded From UniProt

complete

involved_in

GO:0002260

lymphocyte homeostasis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

P

Seeded From UniProt

complete

part_of

GO:0001772

immunological synapse

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O54957
ensembl:ENSMUSP00000032997

C

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008359

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR008359

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:12496963[7]
PMID:14722116[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0042110

T cell activation

PMID:12186560[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050852

T cell receptor signaling pathway

Reactome:R-HSA-202403

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038095

Fc-epsilon receptor signaling pathway

Reactome:R-HSA-2454202

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-5672965
Reactome:R-HSA-434836
Reactome:R-HSA-2730892
Reactome:R-HSA-2730889
Reactome:R-HSA-2730858
Reactome:R-HSA-2730856
Reactome:R-HSA-2730851
Reactome:R-HSA-2730847
Reactome:R-HSA-2730843
Reactome:R-HSA-2730841
Reactome:R-HSA-2730840
Reactome:R-HSA-2730833
Reactome:R-HSA-2424487
Reactome:R-HSA-2424486
Reactome:R-HSA-2424485
Reactome:R-HSA-2424484
Reactome:R-HSA-2424481
Reactome:R-HSA-2424477
Reactome:R-HSA-2424476
Reactome:R-HSA-2396606
Reactome:R-HSA-2396599
Reactome:R-HSA-2396594
Reactome:R-HSA-2396561
Reactome:R-HSA-2395801
Reactome:R-HSA-213407
Reactome:R-HSA-213406
Reactome:R-HSA-202375
Reactome:R-HSA-202331
Reactome:R-HSA-202325
Reactome:R-HSA-202248
Reactome:R-HSA-202245
Reactome:R-HSA-202241
Reactome:R-HSA-202216
Reactome:R-HSA-202212

ECO:0000304

author statement supported by traceable reference used in manual assertion


































C

Seeded From UniProt

complete

involved_in

GO:0000165

MAPK cascade

Reactome:R-HSA-5673001

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

involved_in

GO:0043303

mast cell degranulation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0467

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Roose, JP et al. (2003) T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 1 E53 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Hartgroves, LC et al. (2003) Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J. Biol. Chem. 278 20389-94 PubMed GONUTS page
  3. ↑ 3.0 3.1 Goda, S et al. (2004) Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein. J. Immunol. 172 5379-87 PubMed GONUTS page
  4. ↑ Zhang, W et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 83-92 PubMed GONUTS page
  5. ↑ 5.0 5.1 Perez-Villar, JJ et al. (2002) Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry 41 10732-40 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  7. ↑ Irles, C et al. (2003) CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling. Nat. Immunol. 4 189-97 PubMed GONUTS page
  8. ↑ Koonpaew, S et al. (2004) The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J. Biol. Chem. 279 11229-35 PubMed GONUTS page
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