HUMAN:LARP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	LARP1 (synonyms: KIAA0731, LARP)
Protein Name(s)	La-related protein 1 La ribonucleoprotein domain family member 1
External Links
UniProt	Q6PKG0
EMBL	BC001460 BC033856 AK091465 AB018274 AL133034
CCDS	CCDS4328.1
PIR	T42646
RefSeq	NP_056130.2 XP_005268461.1
UniGene	Hs.292078
PDB	4ZC4 5C0V 5V4R 5V7C 5V87
PDBsum	4ZC4 5C0V 5V4R 5V7C 5V87
ProteinModelPortal	Q6PKG0
SMR	Q6PKG0
BioGrid	116947
IntAct	Q6PKG0
MINT	Q6PKG0
STRING	9606.ENSP00000336721
CarbonylDB	Q6PKG0
iPTMnet	Q6PKG0
PhosphoSitePlus	Q6PKG0
SwissPalm	Q6PKG0
DMDM	73621135
EPD	Q6PKG0
MaxQB	Q6PKG0
PaxDb	Q6PKG0
PeptideAtlas	Q6PKG0
PRIDE	Q6PKG0
DNASU	23367
Ensembl	ENST00000336314
GeneID	23367
KEGG	hsa:23367
UCSC	uc003lvo.4
CTD	23367
DisGeNET	23367
EuPathDB	HostDB:ENSG00000155506.16
GeneCards	LARP1
HGNC	HGNC:29531
HPA	CAB015222 HPA051397 HPA054819
MIM	612059
neXtProt	NX_Q6PKG0
OpenTargets	ENSG00000155506
PharmGKB	PA142671564
eggNOG	KOG2590 COG5193
GeneTree	ENSGT00390000000523
HOGENOM	HOG000113283
HOVERGEN	HBG054322
InParanoid	Q6PKG0
KO	K18757
OMA	SQHSDTQ
OrthoDB	EOG091G02X0
PhylomeDB	Q6PKG0
TreeFam	TF314516
ChiTaRS	LARP1
GeneWiki	LARP1
GenomeRNAi	23367
PMAP-CutDB	Q6PKG0
PRO	PR:Q6PKG0
Proteomes	UP000005640
Bgee	ENSG00000155506
CleanEx	HS_LARP1
ExpressionAtlas	Q6PKG0
Genevisible	Q6PKG0
GO	GO:0005737 GO:0010494 GO:0016020 GO:0045296 GO:0008190 GO:0003730 GO:0048027 GO:0003723 GO:0000339 GO:0008494 GO:0031369 GO:0008283 GO:0072752 GO:0048255 GO:0017148 GO:0016239 GO:0045070 GO:1990928 GO:0031929 GO:0038202 GO:0006413
Gene3D	1.10.10.10
InterPro	IPR006607 IPR006630 IPR036388 IPR036390
Pfam	PF05383
SMART	SM00684 SM00715
SUPFAM	SSF46785
PROSITE	PS50961

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0045948	positive regulation of translational initiation	PMID:29244122^[1]	ECO:0000315			P	Luciferase reporter mRNA is sensitive to competition with cap analog and translation in mTOR-inhibited extracts is less. The 5'end of mRNA was truncated by encoding hammerhead ribozyme upstream of 5'UTR. Primer extension assays proved ligation efficiency of 90%. Translation of TOP reporter is more repressed in mTOR inhibited extracts. This means no/less production of luciferase. figure 1 D,E and Sup. figure 2	complete CACAO 13249
enables	GO:0000340	RNA 7-methylguanosine cap binding	PMID:28379136^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
colocalizes_with	GO:0042788	polysomal ribosome	PMID:28673543^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0043024	ribosomal small subunit binding	PMID:28673543^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:28673543^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	PMID:28673543^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:28379136^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045947	negative regulation of translational initiation	PMID:28379136^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:26206669^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0017148	negative regulation of translation	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1990928	response to amino acid starvation	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0005844	polysome	PMID:25940091^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0072752	cellular response to rapamycin	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
colocalizes_with	GO:0031931	TORC1 complex	PMID:25940091^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	PMID:25940091^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0038202	TORC1 signaling	PMID:25940091^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045070	positive regulation of viral genome replication	PMID:26735137^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:22354037^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0048027	mRNA 5'-UTR binding	PMID:24532714^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[11]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[12]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
colocalizes_with	GO:0031931	TORC1 complex	PMID:24532714^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0031929	TOR signaling	PMID:24532714^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0031369	translation initiation factor binding	PMID:24532714^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008494	translation activator activity	PMID:24532714^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:24532714^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008190	eukaryotic initiation factor 4E binding	PMID:20430826^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06730	F	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	PMID:20430826^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	PMID:24532714^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20430826^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24532714^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:23711370^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000339	RNA cap binding	PMID:24532714^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008494	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0648	P	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Philippe, L et al. (2018) La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. Nucleic Acids Res. 46 1457-1469 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lahr, RM et al. (2017) La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife 6 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Gentilella, A et al. (2017) Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes. Mol. Cell 67 55-70.e4 PubMed GONUTS page
↑ Lahr, RM et al. (2015) The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Nucleic Acids Res. 43 8077-88 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Fonseca, BD et al. (2015) La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J. Biol. Chem. 290 15996-6020 PubMed GONUTS page
↑ Suzuki, Y et al. (2016) Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication. PLoS Pathog. 12 e1005357 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ McKnight, NC et al. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 31 1931-46 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Tcherkezian, J et al. (2014) Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev. 28 357-71 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Burrows, C et al. (2010) The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res. 38 5542-53 PubMed GONUTS page
↑ Aoki, K et al. (2013) LARP1 specifically recognizes the 3' terminus of poly(A) mRNA. FEBS Lett. 587 2173-8 PubMed GONUTS page

[PMID:29244122-1] Philippe, L et al. (2018) La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. Nucleic Acids Res. 46 1457-1469 PubMed GONUTS page

[PMID:28379136-2] 2.0 ^2.1 ^2.2 Lahr, RM et al. (2017) La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs. Elife 6 PubMed GONUTS page

[PMID:28673543-3] 3.0 ^3.1 ^3.2 ^3.3 Gentilella, A et al. (2017) Autogenous Control of 5′TOP mRNA Stability by 40S Ribosomes. Mol. Cell 67 55-70.e4 PubMed GONUTS page

[PMID:26206669-4] Lahr, RM et al. (2015) The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5'TOP sequence. Nucleic Acids Res. 43 8077-88 PubMed GONUTS page

[PMID:25468996-5] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:25940091-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 ^6.7 ^6.8 Fonseca, BD et al. (2015) La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J. Biol. Chem. 290 15996-6020 PubMed GONUTS page

[PMID:26735137-7] Suzuki, Y et al. (2016) Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication. PLoS Pathog. 12 e1005357 PubMed GONUTS page

[PMID:19946888-8] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22354037-9] McKnight, NC et al. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 31 1931-46 PubMed GONUTS page

[PMID:24532714-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Tcherkezian, J et al. (2014) Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev. 28 357-71 PubMed GONUTS page

[PMID:22681889-11] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-12] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:20430826-13] 13.0 ^13.1 ^13.2 Burrows, C et al. (2010) The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res. 38 5542-53 PubMed GONUTS page

[PMID:23711370-14] Aoki, K et al. (2013) LARP1 specifically recognizes the 3' terminus of poly(A) mRNA. FEBS Lett. 587 2173-8 PubMed GONUTS page

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HUMAN:LARP1

Contents

Annotations

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References

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