HUMAN:KPCI

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	PRKCI (synonyms: DXS1179E)
Protein Name(s)	Protein kinase C iota type Atypical protein kinase C-lambda/iota PRKC-lambda/iota aPKC-lambda/iota nPKC-iota
External Links
UniProt	P41743
EMBL	L18964 L33881 CH471052 CH471052 BC022016
CCDS	CCDS3212.2
PIR	A49509
RefSeq	NP_002731.4
UniGene	Hs.478199
PDB	1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
PDBsum	1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8
ProteinModelPortal	P41743
SMR	P41743
BioGrid	111570
DIP	DIP-31311N
IntAct	P41743
MINT	MINT-5004219
STRING	9606.ENSP00000295797
BindingDB	P41743
ChEMBL	CHEMBL2093867
DrugBank	DB00675
GuidetoPHARMACOLOGY	1490
PhosphoSite	P41743
DMDM	239938658
MaxQB	P41743
PaxDb	P41743
PRIDE	P41743
DNASU	5584
Ensembl	ENST00000295797
GeneID	5584
KEGG	hsa:5584
UCSC	uc003fgs.2
CTD	5584
GeneCards	GC03P169940
HGNC	HGNC:9404
HPA	HPA026574 HPA038635
MIM	600539
neXtProt	NX_P41743
PharmGKB	PA33768
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	P41743
KO	K06069
OMA	FEPSISY
OrthoDB	EOG7HF1J3
PhylomeDB	P41743
TreeFam	TF102004
BRENDA	2.7.11.13
Reactome	REACT_13415 REACT_19373
SignaLink	P41743
ChiTaRS	PRKCI
EvolutionaryTrace	P41743
GeneWiki	PRKCI
GenomeRNAi	5584
NextBio	21656
PRO	PR:P41743
Proteomes	UP000005640
Bgee	P41743
CleanEx	HS_PRKCI
Genevestigator	P41743
GO	GO:0016324 GO:0031252 GO:0005737 GO:0005829 GO:0005768 GO:0070062 GO:0000139 GO:0045171 GO:0015630 GO:0005634 GO:0005886 GO:0043234 GO:0043220 GO:0005923 GO:0005524 GO:0005543 GO:0004672 GO:0004697 GO:0004674 GO:0008270 GO:0007015 GO:0034329 GO:0016477 GO:0045216 GO:0032869 GO:0007010 GO:0035089 GO:0045197 GO:0042462 GO:0048194 GO:0035556 GO:0061024 GO:0043066 GO:0034351 GO:0043524 GO:0048011 GO:2000353 GO:0090004 GO:0060252 GO:0046326 GO:0010976 GO:0051092 GO:0006468 GO:0006612 GO:0070555 GO:0046903 GO:0070830 GO:0016192
InterPro	IPR000961 IPR020454 IPR011009 IPR000270 IPR002219 IPR012233 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24357:SF60
Pfam	PF00130 PF00564 PF00069 PF00433
PIRSF	PIRSF000554
PRINTS	PR00008
SMART	SM00109 SM00666 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS00107 PS50011 PS00108 PS00479 PS50081

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21983565^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21983565^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62074	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62074	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62074	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62074	F		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	PMID:19327373^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061024	membrane organization	PMID:11257119^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	PMID:21419810^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:10467349^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046903	secretion	PMID:8226978^[7]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045216	cell-cell junction organization	PMID:11257119^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:10467349^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034351	negative regulation of glial cell apoptotic process	PMID:21419810^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010976	positive regulation of neuron projection development	PMID:10467349^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	PMID:11257119^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006612	protein targeting to membrane	PMID:11257119^[4]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8226978^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21419810^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11257119^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21419810^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11260256^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:8226978^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8226978^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11724794^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
part_of	GO:0045171	intercellular bridge	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0015630	microtubule cytoskeleton	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0048194	C		Seeded From UniProt	complete
involved_in	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
involved_in	GO:0070555	response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
involved_in	GO:0048194	Golgi vesicle budding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
involved_in	GO:0043434	response to peptide hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
involved_in	GO:0016477	cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	P		Seeded From UniProt	complete
part_of	GO:0005923	bicellular tight junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1M7Y5 ensembl:ENSRNOP00000012924	C		Seeded From UniProt	complete
involved_in	GO:1903078	positive regulation of protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
part_of	GO:0045177	apical part of cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	C		Seeded From UniProt	complete
part_of	GO:0043220	Schmidt-Lanterman incisure	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	C		Seeded From UniProt	complete
involved_in	GO:0042462	eye photoreceptor cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
involved_in	GO:0035089	establishment of apical/basal cell polarity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
part_of	GO:0016324	apical plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	C		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	C		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62074 ensembl:ENSMUSP00000103884	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR012233 InterPro:IPR017892	F		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034661	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR012233 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892 InterPro:IPR034661	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002219	P		Seeded From UniProt	complete
enables	GO:0004697	protein kinase C activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.13	F		Seeded From UniProt	complete
involved_in	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	PMID:14676191^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016192	vesicle-mediated transport	PMID:11257119^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8226978^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070830	bicellular tight junction assembly	Reactome:R-HSA-420029	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045747	positive regulation of Notch signaling pathway	Reactome:R-HSA-9021357	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-419981	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-419981 Reactome:R-HSA-193684	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9021357	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-9021357 Reactome:R-HSA-193703	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967 UniProtKB-SubCell:SL-0101	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Motegi, F et al. (2011) Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat. Cell Biol. 13 1361-7 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ Staiger, K et al. (2009) Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. Microvasc. Res. 78 40-4 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Suzuki, A et al. (2001) Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152 1183-96 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Desai, S et al. (2011) PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway. Biochim. Biophys. Acta 1813 1190-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Wooten, MW et al. (1999) Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway. Cell Death Differ. 6 753-64 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Selbie, LA et al. (1993) Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. J. Biol. Chem. 268 24296-302 PubMed GONUTS page
↑ Noda, Y et al. (2001) Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6 107-19 PubMed GONUTS page
↑ Tisdale, EJ (2002) Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway. J. Biol. Chem. 277 3334-41 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Brajenovic, M et al. (2004) Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279 12804-11 PubMed GONUTS page

[PMID:21983565-1] 1.0 ^1.1 Motegi, F et al. (2011) Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes. Nat. Cell Biol. 13 1361-7 PubMed GONUTS page

[PMID:19056867-2] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:19327373-3] Staiger, K et al. (2009) Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells. Microvasc. Res. 78 40-4 PubMed GONUTS page

[PMID:11257119-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Suzuki, A et al. (2001) Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures. J. Cell Biol. 152 1183-96 PubMed GONUTS page

[PMID:21419810-5] 5.0 ^5.1 ^5.2 ^5.3 Desai, S et al. (2011) PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway. Biochim. Biophys. Acta 1813 1190-7 PubMed GONUTS page

[PMID:10467349-6] 6.0 ^6.1 ^6.2 Wooten, MW et al. (1999) Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway. Cell Death Differ. 6 753-64 PubMed GONUTS page

[PMID:8226978-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Selbie, LA et al. (1993) Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. J. Biol. Chem. 268 24296-302 PubMed GONUTS page

[PMID:11260256-8] Noda, Y et al. (2001) Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6 107-19 PubMed GONUTS page

[PMID:11724794-9] Tisdale, EJ (2002) Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway. J. Biol. Chem. 277 3334-41 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:14676191-11] Brajenovic, M et al. (2004) Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J. Biol. Chem. 279 12804-11 PubMed GONUTS page

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HUMAN:KPCI

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