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HUMAN:KLK4
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | KLK4 (synonyms: EMSP1, PRSS17, PSTS) | |
| Protein Name(s) | Kallikrein-4
Enamel matrix serine proteinase 1 Kallikrein-like protein 1 KLK-L1 Prostase Serine protease 17 | |
| External Links | ||
| UniProt | Q9Y5K2 | |
| EMBL | AF113140 AF113141 AF135023 AF148532 AF243527 AF228497 AF259969 AF259971 AC037199 BC069325 BC069403 BC069429 BC069489 BC096175 BC096178 AF126401 | |
| CCDS | CCDS12809.1 | |
| RefSeq | NP_004908.3 | |
| UniGene | Hs.218366 | |
| PDB | 2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA | |
| PDBsum | 2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA | |
| ProteinModelPortal | Q9Y5K2 | |
| SMR | Q9Y5K2 | |
| BioGrid | 114982 | |
| STRING | 9606.ENSP00000326159 | |
| BindingDB | Q9Y5K2 | |
| ChEMBL | CHEMBL4446 | |
| MEROPS | S01.251 | |
| DMDM | 317373372 | |
| PaxDb | Q9Y5K2 | |
| PRIDE | Q9Y5K2 | |
| DNASU | 9622 | |
| Ensembl | ENST00000324041 ENST00000431178 | |
| GeneID | 9622 | |
| KEGG | hsa:9622 | |
| UCSC | uc002pua.1 | |
| CTD | 9622 | |
| GeneCards | GC19M051409 | |
| H-InvDB | HIX0039968 | |
| HGNC | HGNC:6365 | |
| HPA | HPA051839 | |
| MIM | 204700 603767 | |
| neXtProt | NX_Q9Y5K2 | |
| Orphanet | 100033 | |
| PharmGKB | PA30154 | |
| eggNOG | COG5640 | |
| GeneTree | ENSGT00760000118862 | |
| HOGENOM | HOG000251820 | |
| HOVERGEN | HBG013304 | |
| InParanoid | Q9Y5K2 | |
| KO | K08666 | |
| OMA | NGEDCSP | |
| OrthoDB | EOG75B84T | |
| PhylomeDB | Q9Y5K2 | |
| TreeFam | TF331065 | |
| ChiTaRS | KLK4 | |
| EvolutionaryTrace | Q9Y5K2 | |
| GeneWiki | KLK4 | |
| GenomeRNAi | 9622 | |
| NextBio | 36105 | |
| PRO | PR:Q9Y5K2 | |
| Proteomes | UP000005640 | |
| Bgee | Q9Y5K2 | |
| CleanEx | HS_KLK4 | |
| ExpressionAtlas | Q9Y5K2 | |
| Genevestigator | Q9Y5K2 | |
| GO | GO:0005576 GO:0046872 GO:0004252 GO:0008236 GO:0097186 GO:0022617 GO:0030163 GO:0006508 | |
| InterPro | IPR001254 IPR018114 IPR001314 IPR009003 | |
| Pfam | PF00089 | |
| PRINTS | PR00722 | |
| SMART | SM00020 | |
| SUPFAM | SSF50494 | |
| PROSITE | PS50240 PS00134 PS00135 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0097186 |
amelogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000303 |
author statement without traceable support used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097186 |
amelogenesis |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861379 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0030141 |
secretory granule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:3615275 |
C |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0022617 |
extracellular matrix disassembly |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1861379 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004252 |
serine-type endopeptidase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031214 |
biomineral tissue development |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008236 |
serine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Hart, PS et al. (2004) Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. J. Med. Genet. 41 545-9 PubMed GONUTS page
- ↑ 2.0 2.1 Stephenson, SA et al. (1999) Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J. Biol. Chem. 274 23210-4 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 4.0 4.1 Nelson, PS et al. (1999) Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc. Natl. Acad. Sci. U.S.A. 96 3114-9 PubMed GONUTS page
