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HUMAN:KLK4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KLK4 (synonyms: EMSP1, PRSS17, PSTS)
Protein Name(s) Kallikrein-4

Enamel matrix serine proteinase 1 Kallikrein-like protein 1 KLK-L1 Prostase Serine protease 17

External Links
UniProt Q9Y5K2
EMBL AF113140
AF113141
AF135023
AF148532
AF243527
AF228497
AF259969
AF259971
AC037199
BC069325
BC069403
BC069429
BC069489
BC096175
BC096178
AF126401
CCDS CCDS12809.1
RefSeq NP_004908.3
UniGene Hs.218366
PDB 2BDG
2BDH
2BDI
4K1E
4K8Y
4KEL
4KGA
PDBsum 2BDG
2BDH
2BDI
4K1E
4K8Y
4KEL
4KGA
ProteinModelPortal Q9Y5K2
SMR Q9Y5K2
BioGrid 114982
STRING 9606.ENSP00000326159
BindingDB Q9Y5K2
ChEMBL CHEMBL4446
MEROPS S01.251
DMDM 317373372
PaxDb Q9Y5K2
PRIDE Q9Y5K2
DNASU 9622
Ensembl ENST00000324041
ENST00000431178
GeneID 9622
KEGG hsa:9622
UCSC uc002pua.1
CTD 9622
GeneCards GC19M051409
H-InvDB HIX0039968
HGNC HGNC:6365
HPA HPA051839
MIM 204700
603767
neXtProt NX_Q9Y5K2
Orphanet 100033
PharmGKB PA30154
eggNOG COG5640
GeneTree ENSGT00760000118862
HOGENOM HOG000251820
HOVERGEN HBG013304
InParanoid Q9Y5K2
KO K08666
OMA NGEDCSP
OrthoDB EOG75B84T
PhylomeDB Q9Y5K2
TreeFam TF331065
ChiTaRS KLK4
EvolutionaryTrace Q9Y5K2
GeneWiki KLK4
GenomeRNAi 9622
NextBio 36105
PRO PR:Q9Y5K2
Proteomes UP000005640
Bgee Q9Y5K2
CleanEx HS_KLK4
ExpressionAtlas Q9Y5K2
Genevestigator Q9Y5K2
GO GO:0005576
GO:0046872
GO:0004252
GO:0008236
GO:0097186
GO:0022617
GO:0030163
GO:0006508
InterPro IPR001254
IPR018114
IPR001314
IPR009003
Pfam PF00089
PRINTS PR00722
SMART SM00020
SUPFAM SSF50494
PROSITE PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0097186

amelogenesis

PMID:15235027[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

PMID:10438493[2]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

PMID:10438493[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097186

amelogenesis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861379
PANTHER:PTN001956424
UniProtKB:Q9Y5K2

P

Seeded From UniProt

complete

part_of

GO:0030141

secretory granule

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:3615275
PANTHER:PTN000668716

C

Seeded From UniProt

complete

involved_in

GO:0022617

extracellular matrix disassembly

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1861379
PANTHER:PTN001956424

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

PMID:10077646[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10077646[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0031214

biomineral tissue development

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0091

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Hart, PS et al. (2004) Mutation in kallikrein 4 causes autosomal recessive hypomaturation amelogenesis imperfecta. J. Med. Genet. 41 545-9 PubMed GONUTS page
  2. 2.0 2.1 Stephenson, SA et al. (1999) Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J. Biol. Chem. 274 23210-4 PubMed GONUTS page
  3. 3.0 3.1 3.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. 4.0 4.1 Nelson, PS et al. (1999) Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. Proc. Natl. Acad. Sci. U.S.A. 96 3114-9 PubMed GONUTS page