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HUMAN:KLH12

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KLHL12 (synonyms: C3IP1)
Protein Name(s) Kelch-like protein 12

CUL3-interacting protein 1 DKIR homolog hDKIR

External Links
UniProt Q53G59
EMBL AF190900
AK027656
AK301791
AK223072
AC096632
BC003183
BC004175
CCDS CCDS1429.1
RefSeq NP_067646.1
XP_005245460.1
UniGene Hs.706793
PDB 2VPJ
PDBsum 2VPJ
ProteinModelPortal Q53G59
SMR Q53G59
BioGrid 121890
IntAct Q53G59
MINT MINT-1434520
STRING 9606.ENSP00000356230
PhosphoSite Q53G59
DMDM 97054498
MaxQB Q53G59
PaxDb Q53G59
PRIDE Q53G59
DNASU 59349
Ensembl ENST00000367261
GeneID 59349
KEGG hsa:59349
UCSC uc001gyn.1
uc010pqc.1
CTD 59349
GeneCards GC01M202860
HGNC HGNC:19360
MIM 614522
neXtProt NX_Q53G59
PharmGKB PA134952416
eggNOG NOG73120
GeneTree ENSGT00760000118931
HOGENOM HOG000230814
HOVERGEN HBG014286
InParanoid Q53G59
KO K10450
OMA TEPFIRC
OrthoDB EOG7HTHGF
PhylomeDB Q53G59
TreeFam TF329218
Reactome REACT_200841
UniPathway UPA00143
ChiTaRS KLHL12
EvolutionaryTrace Q53G59
GeneWiki KLHL12
GenomeRNAi 59349
NextBio 65257
PRO PR:Q53G59
Proteomes UP000005640
Bgee Q53G59
CleanEx HS_KLHL12
ExpressionAtlas Q53G59
Genevestigator Q53G59
GO GO:0031463
GO:0030134
GO:0000139
GO:0048208
GO:0006888
GO:0006513
GO:0016055
Gene3D 2.130.10.80
InterPro IPR011705
IPR000210
IPR011333
IPR013069
IPR015916
IPR017096
IPR006652
Pfam PF07707
PF00651
PF01344
PIRSF PIRSF037037
SMART SM00875
SM00225
SM00612
SUPFAM SSF54695
PROSITE PS50097

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0030127

COPII vesicle coat

PMID:27716508[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

PMID:27716508[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048208

COPII vesicle coating

PMID:27716508[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006513

protein monoubiquitination

PMID:27716508[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014029

neural crest formation

PMID:27716508[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0014032

neural crest cell development

PMID:27716508[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048208

COPII vesicle coating

PMID:22358839[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031463

Cul3-RING ubiquitin ligase complex

PMID:22358839[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0030134

COPII-coated ER to Golgi transport vesicle

PMID:22358839[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

PMID:20970343[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006888

endoplasmic reticulum to Golgi vesicle-mediated transport

PMID:22358839[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006513

protein monoubiquitination

PMID:22358839[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0048208

COPII vesicle coating

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001973791
UniProtKB:Q53G59

P

Seeded From UniProt

complete

part_of

GO:0030134

COPII-coated ER to Golgi transport vesicle

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001973791
UniProtKB:Q53G59

C

Seeded From UniProt

complete

involved_in

GO:0006513

protein monoubiquitination

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001973791
UniProtKB:Q53G59

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:27107012[5]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q53G59

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:25416956[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q53G59

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:16189514[7]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q53G59

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048208

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048208

C

Seeded From UniProt

complete

part_of

GO:0000139

Golgi membrane

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0048208

C

Seeded From UniProt

complete

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

Reactome:R-HSA-4641258

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1504213
Reactome:R-HSA-1504193
Reactome:R-HSA-1504190

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0016192

vesicle-mediated transport

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0931

P

Seeded From UniProt

complete

involved_in

GO:0016055

Wnt signaling pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0879

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

part_of

GO:0030134

COPII-coated ER to Golgi transport vesicle

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0077

C

Seeded From UniProt

complete

involved_in

GO:0016567

protein ubiquitination

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00143

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 McGourty, CA et al. (2016) Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. Cell 167 525-538.e14 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Jin, L et al. (2012) Ubiquitin-dependent regulation of COPII coat size and function. Nature 482 495-500 PubMed GONUTS page
  3. ↑ Funato, Y et al. (2010) Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Curr. Biol. 20 1945-52 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. ↑ Yachie, N et al. (2016) Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol. Syst. Biol. 12 863 PubMed GONUTS page
  6. ↑ Rolland, T et al. (2014) A proteome-scale map of the human interactome network. Cell 159 1212-26 PubMed GONUTS page
  7. ↑ Rual, JF et al. (2005) Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 1173-8 PubMed GONUTS page
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