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HUMAN:KIF2C
Contents
Species (Taxon ID) | Homo sapiens (Human). (9606) | |
Gene Name(s) | KIF2C (synonyms: KNSL6) | |
Protein Name(s) | Kinesin-like protein KIF2C
Kinesin-like protein 6 Mitotic centromere-associated kinesin MCAK | |
External Links | ||
UniProt | Q99661 | |
EMBL | U63743 AY026505 BT006759 CR450302 AB264115 AL592166 AL592166 CH471059 BC008764 BC014924 | |
CCDS | CCDS512.1 CCDS72774.1 | |
RefSeq | NP_001284584.1 NP_001284585.1 NP_001284586.1 NP_006836.2 | |
UniGene | Hs.720061 | |
PDB | 2HEH | |
PDBsum | 2HEH | |
ProteinModelPortal | Q99661 | |
SMR | Q99661 | |
BioGrid | 116195 | |
IntAct | Q99661 | |
MINT | MINT-4725759 | |
STRING | 9606.ENSP00000361298 | |
BindingDB | Q99661 | |
ChEMBL | CHEMBL5967 | |
PhosphoSite | Q99661 | |
DMDM | 20141607 | |
MaxQB | Q99661 | |
PaxDb | Q99661 | |
PRIDE | Q99661 | |
DNASU | 11004 | |
Ensembl | ENST00000372217 ENST00000372224 | |
GeneID | 11004 | |
KEGG | hsa:11004 | |
UCSC | uc001cmg.4 uc001cmh.4 | |
CTD | 11004 | |
GeneCards | GC01P045208 | |
HGNC | HGNC:6393 | |
HPA | HPA006432 | |
MIM | 604538 | |
neXtProt | NX_Q99661 | |
PharmGKB | PA30182 | |
eggNOG | COG5059 | |
GeneTree | ENSGT00770000120451 | |
HOVERGEN | HBG003875 | |
InParanoid | Q99661 | |
KO | K10393 | |
OMA | DETASNE | |
PhylomeDB | Q99661 | |
TreeFam | TF105222 | |
Reactome | REACT_121399 REACT_150425 REACT_150471 REACT_25201 REACT_682 | |
ChiTaRS | KIF2C | |
EvolutionaryTrace | Q99661 | |
GeneWiki | KIF2C | |
GenomeRNAi | 11004 | |
NextBio | 41799 | |
PRO | PR:Q99661 | |
Proteomes | UP000005640 | |
Bgee | Q99661 | |
CleanEx | HS_KIF2C | |
ExpressionAtlas | Q99661 | |
Genevestigator | Q99661 | |
GO | GO:0000775 GO:0000777 GO:0005829 GO:0005871 GO:0016020 GO:0015630 GO:0035371 GO:0005634 GO:0005524 GO:0016887 GO:0019237 GO:0003777 GO:0051010 GO:0019886 GO:0006200 GO:0007596 GO:0008283 GO:0007059 GO:0030951 GO:0008152 GO:0007019 GO:0007018 GO:0000278 GO:0007067 GO:0051983 | |
Gene3D | 3.40.850.10 | |
InterPro | IPR027640 IPR019821 IPR001752 IPR027417 | |
PANTHER | PTHR24115 | |
Pfam | PF00225 | |
PRINTS | PR00380 | |
SMART | SM00129 | |
SUPFAM | SSF52540 | |
PROSITE | PS00411 PS50067 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
part_of |
GO:0035371 |
microtubule plus-end |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051315 |
attachment of mitotic spindle microtubules to kinetochore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051310 |
metaphase plate congression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007080 |
mitotic metaphase plate congression |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0015630 |
microtubule cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030951 |
establishment or maintenance of microtubule cytoskeleton polarity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051983 |
regulation of chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051010 |
microtubule plus-end binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0035371 |
microtubule plus-end |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007019 |
microtubule depolymerization |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007019 |
microtubule depolymerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0005881 |
cytoplasmic microtubule |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0000776 |
kinetochore |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016887 |
ATPase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:108426 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0008017 |
microtubule binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0000352 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007018 |
microtubule-based movement |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001308 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005874 |
microtubule |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0004378 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005871 |
kinesin complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001308 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005813 |
centrosome |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0030268 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000756891 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003777 |
microtubule motor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0001308 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q922S8 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0003777 |
microtubule motor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007018 |
microtubule-based movement |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008017 |
microtubule binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0035371 |
microtubule plus-end |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007019 |
microtubule depolymerization |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019237 |
centromeric DNA binding |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005871 |
kinesin complex |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0003777 |
microtubule motor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019886 |
antigen processing and presentation of exogenous peptide antigen via MHC class II |
Reactome:R-HSA-2132295 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007018 |
microtubule-based movement |
Reactome:R-HSA-983189 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006890 |
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Reactome:R-HSA-6811434 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-990489 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0000775 |
chromosome, centromeric region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005874 |
microtubule |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000776 |
kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0000777 |
condensed chromosome kinetochore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Shrestha, RL & Draviam, VM (2013) Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr. Biol. 23 1514-26 PubMed GONUTS page
- ↑ Zhu, C et al. (2005) Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol. Biol. Cell 16 3187-99 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page
- ↑ 5.0 5.1 Bakhoum, SF et al. (2009) Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 11 27-35 PubMed GONUTS page
- ↑ Honnappa, S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138 366-76 PubMed GONUTS page
- ↑ 7.0 7.1 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page
- ↑ 8.0 8.1 Andrews, PD et al. (2004) Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 253-68 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 Kim, IG et al. (1997) Cloning and expression of human mitotic centromere-associated kinesin gene. Biochim. Biophys. Acta 1359 181-6 PubMed GONUTS page
a
c
- Catarrhini
- GO:0007049 ! cell cycle
- GO:0051301 ! cell division
- GO:0019237 ! centromeric DNA binding
- GO:0005813 ! centrosome
- Chordata
- GO:0005694 ! chromosome
- GO:0000775 ! chromosome, centromeric region
- GO:0007059 ! chromosome segregation
- GO:0000777 ! condensed chromosome kinetochore
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005881 ! cytoplasmic microtubule
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
m
- Mammalia
- GO:0016020 ! membrane
- GO:0051310 ! metaphase chromosome alignment
- Metazoa
- GO:0005874 ! microtubule
- GO:0007018 ! microtubule-based movement
- GO:0035371 ! microtubule plus-end
- GO:0003777 ! microtubule motor activity
- GO:0008017 ! microtubule binding
- GO:0007019 ! microtubule depolymerization
- GO:0051010 ! microtubule plus-end binding
- GO:0015630 ! microtubule cytoskeleton
- GO:0007080 ! mitotic metaphase chromosome alignment
p
r