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HUMAN:KIF2C

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KIF2C (synonyms: KNSL6)
Protein Name(s) Kinesin-like protein KIF2C

Kinesin-like protein 6 Mitotic centromere-associated kinesin MCAK

External Links
UniProt Q99661
EMBL U63743
AY026505
BT006759
CR450302
AB264115
AL592166
AL592166
CH471059
BC008764
BC014924
CCDS CCDS512.1
CCDS72774.1
RefSeq NP_001284584.1
NP_001284585.1
NP_001284586.1
NP_006836.2
UniGene Hs.720061
PDB 2HEH
PDBsum 2HEH
ProteinModelPortal Q99661
SMR Q99661
BioGrid 116195
IntAct Q99661
MINT MINT-4725759
STRING 9606.ENSP00000361298
BindingDB Q99661
ChEMBL CHEMBL5967
PhosphoSite Q99661
DMDM 20141607
MaxQB Q99661
PaxDb Q99661
PRIDE Q99661
DNASU 11004
Ensembl ENST00000372217
ENST00000372224
GeneID 11004
KEGG hsa:11004
UCSC uc001cmg.4
uc001cmh.4
CTD 11004
GeneCards GC01P045208
HGNC HGNC:6393
HPA HPA006432
MIM 604538
neXtProt NX_Q99661
PharmGKB PA30182
eggNOG COG5059
GeneTree ENSGT00770000120451
HOVERGEN HBG003875
InParanoid Q99661
KO K10393
OMA DETASNE
PhylomeDB Q99661
TreeFam TF105222
Reactome REACT_121399
REACT_150425
REACT_150471
REACT_25201
REACT_682
ChiTaRS KIF2C
EvolutionaryTrace Q99661
GeneWiki KIF2C
GenomeRNAi 11004
NextBio 41799
PRO PR:Q99661
Proteomes UP000005640
Bgee Q99661
CleanEx HS_KIF2C
ExpressionAtlas Q99661
Genevestigator Q99661
GO GO:0000775
GO:0000777
GO:0005829
GO:0005871
GO:0016020
GO:0015630
GO:0035371
GO:0005634
GO:0005524
GO:0016887
GO:0019237
GO:0003777
GO:0051010
GO:0019886
GO:0006200
GO:0007596
GO:0008283
GO:0007059
GO:0030951
GO:0008152
GO:0007019
GO:0007018
GO:0000278
GO:0007067
GO:0051983
Gene3D 3.40.850.10
InterPro IPR027640
IPR019821
IPR001752
IPR027417
PANTHER PTHR24115
Pfam PF00225
PRINTS PR00380
SMART SM00129
SUPFAM SSF52540
PROSITE PS00411
PS50067

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

part_of

GO:0035371

microtubule plus-end

PMID:23891108[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051315

attachment of mitotic spindle microtubules to kinetochore

PMID:23891108[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

PMID:23891108[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051310

metaphase plate congression

PMID:23891108[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007080

mitotic metaphase plate congression

PMID:15843429[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0015630

microtubule cytoskeleton

GO_REF:0000054

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0030951

establishment or maintenance of microtubule cytoskeleton polarity

PMID:14718566[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051983

regulation of chromosome segregation

PMID:19060894[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051010

microtubule plus-end binding

PMID:19632184[6]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0035371

microtubule plus-end

PMID:21820309[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007019

microtubule depolymerization

PMID:19060894[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007019

microtubule depolymerization

PMID:21820309[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0005881

cytoplasmic microtubule

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P70096

C

Seeded From UniProt

complete

colocalizes_with

GO:0000776

kinetochore

PMID:14960279[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

PMID:14960279[8]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0016887

ATPase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108426
MGI:MGI:1098226
MGI:MGI:2447072
PANTHER:PTN000648413
PomBase:SPBC1604.20c
PomBase:SPBC1685.15c
PomBase:SPBC2F12.13
RGD:621520
TAIR:locus:2148543
TAIR:locus:2157533
UniProtKB:C8V3Q8
UniProtKB:Q0IMS9
UniProtKB:Q6YZ52
UniProtKB:Q7X7H4
UniProtKB:Q96Q89
dictyBase:DDB_G0280967

F

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0000352
FB:FBgn0001308
FB:FBgn0004378
FB:FBgn0011606
MGI:MGI:107689
MGI:MGI:108391
MGI:MGI:109564
MGI:MGI:1098226
MGI:MGI:2447072
PANTHER:PTN000648413
PomBase:SPAC3A11.14c
PomBase:SPAC664.10
PomBase:SPBC1604.20c
PomBase:SPBC1685.15c
PomBase:SPBC2F12.13
RGD:1304996
RGD:1306815
RGD:621538
RGD:621559
SGD:S000006345
TAIR:locus:2129630
TAIR:locus:2136437
TAIR:locus:2148543
TAIR:locus:2157533
UniProtKB:O00139
UniProtKB:P17120
UniProtKB:P33176
UniProtKB:Q02224
UniProtKB:Q02241
UniProtKB:Q0IMS9
UniProtKB:Q8NI77
UniProtKB:Q96Q89
WB:WBGene00006831
WB:WBGene00006974
dictyBase:DDB_G0276369

F

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001308
FB:FBgn0004378
FB:FBgn0004381
MGI:MGI:108426
MGI:MGI:2447072
PANTHER:PTN000648413
UniProtKB:Q0IMS9
UniProtKB:Q6YZ52
UniProtKB:Q7X7H4
WB:WBGene00002222
WB:WBGene00002225
WB:WBGene00002230
WB:WBGene00006831
WB:WBGene00006974
dictyBase:DDB_G0281555

P

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004378
PANTHER:PTN000648413
RGD:1303035
RGD:1304996
RGD:621538
TAIR:locus:2089358
UniProtKB:O00139
UniProtKB:P52732
UniProtKB:Q02224
UniProtKB:Q15058
UniProtKB:Q9HAQ2
WB:WBGene00002228
WB:WBGene00003884
ZFIN:ZDB-GENE-991019-4

C

Seeded From UniProt

complete

part_of

GO:0005871

kinesin complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001308
FB:FBgn0002948
FB:FBgn0004378
MGI:MGI:109202
MGI:MGI:1098229
PANTHER:PTN000648413
RGD:1303035
UniProtKB:D6XFK9
UniProtKB:O77382
UniProtKB:Q57UW8
UniProtKB:Q57X99
UniProtKB:Q582I0
WB:WBGene00003884

C

Seeded From UniProt

complete

part_of

GO:0005813

centrosome

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0030268
PANTHER:PTN000649352
UniProtKB:O00139
WB:WBGene00002219

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000756891
UniProtKB:O00139

C

Seeded From UniProt

complete

enables

GO:0003777

microtubule motor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0001308
FB:FBgn0002948
FB:FBgn0003545
MGI:MGI:108426
MGI:MGI:1098229
MGI:MGI:1098264
MGI:MGI:2447072
PANTHER:PTN000648413
PomBase:SPAC3A11.14c
RGD:621559
SGD:S000000159
SGD:S000000787
TAIR:locus:2115713
UniProtKB:A0A0B4KFR5
UniProtKB:A0A1D8PT88
UniProtKB:O77382
UniProtKB:P17120
UniProtKB:P33176
UniProtKB:Q02224
UniProtKB:Q0IMS9
UniProtKB:Q2M1P5
UniProtKB:Q5T7B8
UniProtKB:Q6YZ52
WB:WBGene00002222
WB:WBGene00002230
WB:WBGene00003884
WB:WBGene00006974
dictyBase:DDB_G0280967
dictyBase:DDB_G0291039

F

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q922S8
ensembl:ENSMUSP00000064261

C

Seeded From UniProt

complete

enables

GO:0003777

microtubule motor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001752
InterPro:IPR019821
InterPro:IPR027640

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001752
InterPro:IPR019821

F

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001752
InterPro:IPR019821
InterPro:IPR027640

P

Seeded From UniProt

complete

enables

GO:0008017

microtubule binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001752

F

Seeded From UniProt

complete

part_of

GO:0035371

microtubule plus-end

PMID:26323690[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0007019

microtubule depolymerization

PMID:26323690[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0019237

centromeric DNA binding

PMID:9434124[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005871

kinesin complex

PMID:9434124[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003777

microtubule motor activity

PMID:9434124[11]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0019886

antigen processing and presentation of exogenous peptide antigen via MHC class II

Reactome:R-HSA-2132295

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007018

microtubule-based movement

Reactome:R-HSA-983189

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006890

retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

Reactome:R-HSA-6811434

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-990489
Reactome:R-HSA-983266
Reactome:R-HSA-983259
Reactome:R-HSA-6811426
Reactome:R-HSA-6811423
Reactome:R-HSA-5666169
Reactome:R-HSA-5666160
Reactome:R-HSA-5666129
Reactome:R-HSA-375302
Reactome:R-HSA-2484822
Reactome:R-HSA-2468287
Reactome:R-HSA-2467811
Reactome:R-HSA-2467809
Reactome:R-HSA-2213248
Reactome:R-HSA-1638821
Reactome:R-HSA-1638803
Reactome:R-HSA-141439
Reactome:R-HSA-141431
Reactome:R-HSA-141422
Reactome:R-HSA-141409

ECO:0000304

author statement supported by traceable reference used in manual assertion




















C

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

part_of

GO:0000775

chromosome, centromeric region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0137
UniProtKB-SubCell:SL-0047

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005874

microtubule

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0493

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

involved_in

GO:0007059

chromosome segregation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0159

P

Seeded From UniProt

complete

part_of

GO:0000776

kinetochore

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0995

C

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

part_of

GO:0000777

condensed chromosome kinetochore

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0149

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Shrestha, RL & Draviam, VM (2013) Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr. Biol. 23 1514-26 PubMed GONUTS page
  2. Zhu, C et al. (2005) Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. Mol. Biol. Cell 16 3187-99 PubMed GONUTS page
  3. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. Cassimeris, L & Morabito, J (2004) TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol. Biol. Cell 15 1580-90 PubMed GONUTS page
  5. 5.0 5.1 Bakhoum, SF et al. (2009) Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat. Cell Biol. 11 27-35 PubMed GONUTS page
  6. Honnappa, S et al. (2009) An EB1-binding motif acts as a microtubule tip localization signal. Cell 138 366-76 PubMed GONUTS page
  7. 7.0 7.1 Tanenbaum, ME et al. (2011) A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21 1356-65 PubMed GONUTS page
  8. 8.0 8.1 Andrews, PD et al. (2004) Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 253-68 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. 10.0 10.1 Watanabe, T et al. (2015) TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. J. Cell Biol. 210 737-51 PubMed GONUTS page
  11. 11.0 11.1 11.2 Kim, IG et al. (1997) Cloning and expression of human mitotic centromere-associated kinesin gene. Biochim. Biophys. Acta 1359 181-6 PubMed GONUTS page