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HUMAN:KI67
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | MKI67 (ECO:0000312 with HGNC:HGNC:7107) | |
| Protein Name(s) | Proliferation marker protein Ki-67 (ECO:0000305)
Antigen identified by monoclonal antibody Ki-67 (ECO:0000303 with PMID:8227122[1]) Antigen KI-67 (ECO:0000305) Antigen Ki67 (ECO:0000305) | |
| External Links | ||
| UniProt | P46013 | |
| EMBL | X65550 X65551 AL390236 AL355529 X94762 | |
| CCDS | CCDS53588.1 CCDS7659.1 | |
| PIR | A48666 | |
| RefSeq | NP_001139438.1 NP_002408.3 | |
| UniGene | Hs.689823 Hs.80976 | |
| PDB | 1R21 2AFF 5J28 | |
| PDBsum | 1R21 2AFF 5J28 | |
| ProteinModelPortal | P46013 | |
| SMR | P46013 | |
| BioGrid | 110434 | |
| DIP | DIP-28132N | |
| IntAct | P46013 | |
| MINT | MINT-137995 | |
| STRING | 9606.ENSP00000357643 | |
| iPTMnet | P46013 | |
| PhosphoSitePlus | P46013 | |
| SwissPalm | P46013 | |
| BioMuta | MKI67 | |
| DMDM | 118572663 | |
| EPD | P46013 | |
| MaxQB | P46013 | |
| PaxDb | P46013 | |
| PeptideAtlas | P46013 | |
| PRIDE | P46013 | |
| Ensembl | ENST00000368653 ENST00000368654 | |
| GeneID | 4288 | |
| KEGG | hsa:4288 | |
| UCSC | uc001lke.4 | |
| CTD | 4288 | |
| DisGeNET | 4288 | |
| GeneCards | MKI67 | |
| HGNC | HGNC:7107 | |
| HPA | CAB000058 CAB068198 HPA000451 HPA001164 | |
| MIM | 176741 | |
| neXtProt | NX_P46013 | |
| OpenTargets | ENSG00000148773 | |
| PharmGKB | PA30825 | |
| eggNOG | ENOG410JR7C ENOG410ZXYW | |
| GeneTree | ENSGT00530000064425 | |
| HOGENOM | HOG000113223 | |
| HOVERGEN | HBG006213 | |
| InParanoid | P46013 | |
| KO | K17582 | |
| OMA | QTPKEKA | |
| OrthoDB | EOG091G005S | |
| PhylomeDB | P46013 | |
| TreeFam | TF336000 | |
| ChiTaRS | MKI67 | |
| EvolutionaryTrace | P46013 | |
| GeneWiki | Ki-67_(protein) | |
| GenomeRNAi | 4288 | |
| PRO | PR:P46013 | |
| Proteomes | UP000005640 | |
| Bgee | ENSG00000148773 | |
| CleanEx | HS_MKI67 | |
| Genevisible | P46013 | |
| GO | GO:0000775 GO:0000793 GO:0005737 GO:0016020 GO:0016604 GO:0005730 GO:0005634 GO:0005524 GO:0003677 GO:0008022 GO:0003723 GO:0031100 GO:0008283 GO:0034605 GO:0006259 GO:0030212 GO:0007126 GO:1902275 GO:0051983 GO:0007088 GO:0014070 | |
| Gene3D | 2.60.200.20 | |
| InterPro | IPR000253 IPR012568 IPR029334 IPR008984 | |
| Pfam | PF00498 PF08065 PF15276 | |
| SMART | SM00240 SM01295 | |
| SUPFAM | SSF49879 | |
| PROSITE | PS50006 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0007088 |
regulation of mitotic nuclear division |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051983 |
regulation of chromosome segregation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
colocalizes_with |
GO:0000793 |
condensed chromosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1902275 |
regulation of chromatin organization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
NOT|involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016604 |
nuclear body |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008283 |
cell population proliferation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
| GO:0005634 |
nucleus |
ECO:0000314 |
C |
Organism: Homo sapiens. Protein Name: Proliferation marker protein Ki-67. Notes: Figure 1D is used. Normal human mammary epithelial cells (HMEC) are stained with Hoechst 33342 to make the nuclei appear blue. They are also immunostained so that Ki67 will appear green. As can be seen in the bottom row, the Ki67 protein is present in the nucleus for HMEC cells whether they are treated with Phytochemicals or not. Thus, Ki67 is linked to the nucleus, in a non-transient manner. |
complete | |||||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Schlüter, C et al. (1993) The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123 513-22 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Cuylen, S et al. (2016) Ki-67 acts as a biological surfactant to disperse mitotic chromosomes. Nature 535 308-12 PubMed GONUTS page
- ↑ Wang, GL et al. (2012) The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line. Oncol. Rep. 27 1944-52 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 Miele, A et al. (2007) The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. J. Cell. Biochem. 102 136-48 PubMed GONUTS page
- ↑ Lewinska, A et al. (2017) Phytochemical-induced nucleolar stress results in the inhibition of breast cancer cell proliferation. Redox Biol 12 469-482 PubMed GONUTS page
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