HUMAN:KCC2A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CAMK2A (synonyms: CAMKA, KIAA0968)
Protein Name(s)	Calcium/calmodulin-dependent protein kinase type II subunit alpha CaM kinase II subunit alpha CaMK-II subunit alpha
External Links
UniProt	Q9UQM7
EMBL	AF145710 AF145711 AB023185 AC011372
CCDS	CCDS43386.1 CCDS43387.1
RefSeq	NP_741960.1
UniGene	Hs.743976
PDB	2VZ6 3SOA
PDBsum	2VZ6 3SOA
ProteinModelPortal	Q9UQM7
SMR	Q9UQM7
BioGrid	107265
DIP	DIP-39705N
IntAct	Q9UQM7
MINT	MINT-95446
STRING	9606.ENSP00000381412
BindingDB	Q9UQM7
ChEMBL	CHEMBL2097164
GuidetoPHARMACOLOGY	1555
PhosphoSite	Q9UQM7
DMDM	296434552
MaxQB	Q9UQM7
PaxDb	Q9UQM7
PRIDE	Q9UQM7
DNASU	815
Ensembl	ENST00000348628 ENST00000398376
GeneID	815
KEGG	hsa:815
UCSC	uc003lru.2
CTD	815
GeneCards	GC05M149579
HGNC	HGNC:1460
HPA	CAB004330
MIM	114078
neXtProt	NX_Q9UQM7
PharmGKB	PA90
eggNOG	COG0515
GeneTree	ENSGT00760000118944
HOGENOM	HOG000233016
HOVERGEN	HBG108055
InParanoid	Q9UQM7
KO	K04515
OMA	ITCTRFS
OrthoDB	EOG7ZD1VM
PhylomeDB	Q9UQM7
TreeFam	TF315229
BRENDA	2.7.11.17
Reactome	REACT_172761 REACT_18307 REACT_200775 REACT_20546 REACT_20568 REACT_20594 REACT_20642 REACT_25078
SignaLink	Q9UQM7
ChiTaRS	CAMK2A
EvolutionaryTrace	Q9UQM7
GeneWiki	CAMK2A
GenomeRNAi	815
NextBio	3304
PRO	PR:Q9UQM7
Proteomes	UP000005640
Bgee	Q9UQM7
CleanEx	HS_CAMK2A
ExpressionAtlas	Q9UQM7
Genevestigator	Q9UQM7
GO	GO:0030054 GO:0005829 GO:0030666 GO:0005739 GO:0005654 GO:0005634 GO:0005886 GO:0042734 GO:0005524 GO:0005516 GO:0004683 GO:0035254 GO:0016301 GO:0042803 GO:0004674 GO:0006816 GO:0019221 GO:0000082 GO:0060333 GO:0018105 GO:0051928 GO:0010666 GO:0051092 GO:0046777 GO:0006468 GO:1902108 GO:0048168 GO:0046928 GO:0002931 GO:0007268
InterPro	IPR020636 IPR013543 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
PANTHER	PTHR24347
Pfam	PF08332 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:2001222	regulation of neuron migration	PMID:29100089^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	C	part_of:(UBERON:0000948)	Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP24	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP25	F		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:18305109^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0038166	angiotensin-activated signaling pathway	PMID:20584908^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	F	has_direct_input:(MGI:MGI:1347359)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	F		Seeded From UniProt	complete
involved_in	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P0DP23	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P11798	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0060996	dendritic spine development	PMID:28130356^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990443	peptidyl-threonine autophosphorylation	PMID:28130356^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28130356^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005954	calcium- and calmodulin-dependent protein kinase complex	PMID:28130356^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	PMID:28130356^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:17052756^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	PMID:17052756^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:17052756^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002389359 WB:WBGene00006779	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1341265 PANTHER:PTN002389359 RGD:2263	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88256 PANTHER:PTN002389359 UniProtKB:Q13557 UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0264607 MGI:MGI:88256 MGI:MGI:88257 PANTHER:PTN002389359 RGD:2261 RGD:2262 RGD:2263 RGD:621802 UniProtKB:Q13557 UniProtKB:Q9UQM7 WB:WBGene00006779	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21884935^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20668654^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UQM7	F		Seeded From UniProt	complete
involved_in	GO:1990443	peptidyl-threonine autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0099148	regulation of synaptic vesicle docking	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
part_of	GO:0098685	Schaffer collateral - CA1 synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	C		Seeded From UniProt	complete
involved_in	GO:0051928	positive regulation of calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0048813	dendrite morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0048168	regulation of neuronal synaptic plasticity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0046928	regulation of neurotransmitter secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
enables	GO:0035254	glutamate receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	C		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
enables	GO:0009931	calcium-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	F		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
involved_in	GO:0000082	G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P11798 ensembl:ENSMUSP00000099952	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543 InterPro:IPR039071	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013543	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR013543	P		Seeded From UniProt	complete
enables	GO:0004683	calmodulin-dependent protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.17	F		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371571	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030666	endocytic vesicle membrane	Reactome:R-HSA-416320	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007223	Wnt signaling pathway, calcium modulating pathway	Reactome:R-HSA-4086398	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-909552 Reactome:R-HSA-4332388 Reactome:R-HSA-4332363 Reactome:R-HSA-4332359 Reactome:R-HSA-4332358 Reactome:R-HSA-4332356	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-5082387	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0770 UniProtKB-SubCell:SL-0258	C		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
part_of	GO:0030054	cell junction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0965	C		Seeded From UniProt	complete
part_of	GO:0045211	postsynaptic membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0628	C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0297	C		Seeded From UniProt	complete
part_of	GO:0043197	dendritic spine	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0284	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Küry, S et al. (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am. J. Hum. Genet. 101 768-788 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rellos, P et al. (2010) Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 8 e1000426 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wang, C et al. (2008) A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J. Biol. Chem. 283 11565-74 PubMed GONUTS page
↑ He, P et al. (2010) Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 285 27869-78 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Stephenson, JR et al. (2017) A Novel Human Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J. Neurosci. 37 2216-2233 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ishiguro, K et al. (2007) Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol. Immunol. 44 2095-100 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chao, LH et al. (2011) A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell 146 732-45 PubMed GONUTS page

[PMID:29100089-1] Küry, S et al. (2017) De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am. J. Hum. Genet. 101 768-788 PubMed GONUTS page

[PMID:20668654-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Rellos, P et al. (2010) Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation. PLoS Biol. 8 e1000426 PubMed GONUTS page

[PMID:18305109-3] 3.0 ^3.1 ^3.2 Wang, C et al. (2008) A novel endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest via p27 stabilization. J. Biol. Chem. 283 11565-74 PubMed GONUTS page

[PMID:20584908-4] He, P et al. (2010) Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated by inositol 1,4,5-triphosphate (IP3) receptor-binding protein released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 285 27869-78 PubMed GONUTS page

[PMID:21630459-5] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:28130356-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Stephenson, JR et al. (2017) A Novel Human Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors. J. Neurosci. 37 2216-2233 PubMed GONUTS page

[PMID:17052756-7] 7.0 ^7.1 ^7.2 Ishiguro, K et al. (2007) Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II. Mol. Immunol. 44 2095-100 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 ^8.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21884935-9] Chao, LH et al. (2011) A mechanism for tunable autoinhibition in the structure of a human Ca2+/calmodulin- dependent kinase II holoenzyme. Cell 146 732-45 PubMed GONUTS page

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HUMAN:KCC2A

Contents

Annotations

Notes

References

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