HUMAN:K2C6A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KRT6A (synonyms: K6A, KRT6D)
Protein Name(s)	Keratin, type II cytoskeletal 6A Cytokeratin-6A CK-6A Cytokeratin-6D CK-6D Keratin-6A K6A Type-II keratin Kb6
External Links
UniProt	P02538
EMBL	L42583 L42575 L42576 L42577 L42578 L42579 L42580 L42581 AH005420 BT006899 BC008807 BC014152 BC069269 BC125058 BC139753 V01516
CCDS	CCDS41786.1
PIR	A57398 I61769
RefSeq	NP_005545.1
UniGene	Hs.700779
ProteinModelPortal	P02538
SMR	P02538
BioGrid	110051
DIP	DIP-533N
IntAct	P02538
STRING	9606.ENSP00000369317
Allergome	3326 415
PhosphoSite	P02538
DMDM	1346344
MaxQB	P02538
PaxDb	P02538
PeptideAtlas	P02538
PRIDE	P02538
DNASU	3853
Ensembl	ENST00000330722
GeneID	3853
KEGG	hsa:3853
UCSC	uc001sam.3
CTD	3853
GeneCards	GC12M052880
GeneReviews	KRT6A
HGNC	HGNC:6443
HPA	HPA045697
MIM	148041 615726
neXtProt	NX_P02538
Orphanet	2309
PharmGKB	PA30231
eggNOG	NOG315845
GeneTree	ENSGT00760000118796
HOGENOM	HOG000230976
HOVERGEN	HBG013015
InParanoid	P02538
KO	K07605
OMA	MQDQVED
OrthoDB	EOG7FV3Q8
PhylomeDB	P02538
TreeFam	TF317854
ChiTaRS	KRT6A
GeneWiki	Keratin_6A
GenomeRNAi	3853
NextBio	15161
PRO	PR:P02538
Proteomes	UP000005640
Bgee	P02538
CleanEx	HS_KRT6A
Genevestigator	P02538
GO	GO:0070062 GO:0045095 GO:0016020 GO:0005634 GO:0005200 GO:0030154 GO:0008284
InterPro	IPR001664 IPR018039 IPR003054
PANTHER	PTHR23239
Pfam	PF00038
PRINTS	PR01276
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:23006328^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide	PMID:23006328^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001899	negative regulation of cytolysis by symbiont of host cells	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000536	negative regulation of entry of bacterium into host cell	PMID:23006328^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051801	cytolysis in other organism involved in symbiotic interaction	PMID:23006328^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50446	P		Seeded From UniProt	complete
involved_in	GO:0002009	morphogenesis of an epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P50446	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19199708^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001831)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21630459^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000019)	Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:7543104^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:7543104^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005200	structural constituent of cytoskeleton	PMID:7543104^[6]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005200	P		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	F		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	C		Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003054	C		Seeded From UniProt	complete
involved_in	GO:0070268	cornification	Reactome:R-HSA-6809371	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031424	keratinization	Reactome:R-HSA-6805567	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8942224 Reactome:R-HSA-6814764 Reactome:R-HSA-6814734 Reactome:R-HSA-6814387 Reactome:R-HSA-6814298 Reactome:R-HSA-6811539 Reactome:R-HSA-6810937 Reactome:R-HSA-6810357 Reactome:R-HSA-6809663 Reactome:R-HSA-6809393 Reactome:R-HSA-6806629 Reactome:R-HSA-6806613 Reactome:R-HSA-6806610 Reactome:R-HSA-6805573 Reactome:R-HSA-6805546	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0416 UniProtKB-KW:KW-0403	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Tam, C et al. (2012) Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J. Clin. Invest. 122 3665-77 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Takahashi, K et al. (1995) Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J. Biol. Chem. 270 18581-92 PubMed GONUTS page

[PMID:23006328-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 ^1.11 ^1.12 ^1.13 ^1.14 ^1.15 Tam, C et al. (2012) Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J. Clin. Invest. 122 3665-77 PubMed GONUTS page

[PMID:23533145-2] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19946888-3] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:19199708-4] Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page

[PMID:21630459-5] Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page

[PMID:7543104-6] 6.0 ^6.1 ^6.2 Takahashi, K et al. (1995) Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J. Biol. Chem. 270 18581-92 PubMed GONUTS page

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HUMAN:K2C6A

Contents

Annotations

Notes

References

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