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HUMAN:K22E

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KRT2 (synonyms: KRT2A, KRT2E)
Protein Name(s) Keratin, type II cytoskeletal 2 epidermal

Cytokeratin-2e CK-2e Epithelial keratin-2e Keratin-2 epidermis Keratin-2e K2e Type-II keratin Kb2

External Links
UniProt P35908
EMBL M99061
AF019084
AC055715
AC055716
BC096294
BC099643
BC099644
CCDS CCDS8835.1
PIR A44861
RefSeq NP_000414.2
UniGene Hs.707
ProteinModelPortal P35908
SMR P35908
BioGrid 110047
IntAct P35908
MINT MINT-1208580
STRING 9606.ENSP00000310861
PhosphoSite P35908
DMDM 239938650
MaxQB P35908
PaxDb P35908
PeptideAtlas P35908
PRIDE P35908
Ensembl ENST00000309680
GeneID 3849
KEGG hsa:3849
UCSC uc001sat.3
CTD 3849
GeneCards GC12M053038
H-InvDB HIX0036877
HGNC HGNC:6439
HPA CAB037321
MIM 146800
600194
neXtProt NX_P35908
Orphanet 455
PharmGKB PA30227
eggNOG NOG146769
GeneTree ENSGT00760000118796
HOGENOM HOG000230976
HOVERGEN HBG013015
InParanoid P35908
KO K07605
OMA TNLDPIF
OrthoDB EOG7FV3Q8
PhylomeDB P35908
TreeFam TF317854
GeneWiki Keratin_2A
GenomeRNAi 3849
NextBio 15145
PRO PR:P35908
Proteomes UP000005640
Bgee P35908
CleanEx HS_KRT2
Genevestigator P35908
GO GO:0005737
GO:0005615
GO:0070062
GO:0005794
GO:0005882
GO:0045111
GO:0045095
GO:0016020
GO:0005634
GO:0005200
GO:0008544
GO:0031424
GO:0032980
GO:0051546
GO:0043616
InterPro IPR001664
IPR018039
IPR003054
PANTHER PTHR23239
Pfam PF00038
PRINTS PR01276
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0045684

positive regulation of epidermis development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q3TTY5

P

Seeded From UniProt

complete

part_of

GO:0001533

cornified envelope

PMID:7543090[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0030280

structural constituent of epidermis

PMID:7543090[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0018149

peptide cross-linking

PMID:7543090[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:23533145[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[3]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[5]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:23580065[6]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001827)

Seeded From UniProt

complete

involved_in

GO:0051546

keratinocyte migration

PMID:15737202[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043616

keratinocyte proliferation

PMID:12598329[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032980

keratinocyte activation

PMID:12598329[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

PMID:12598329[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045684

positive regulation of epidermis development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

P

Seeded From UniProt

complete

involved_in

GO:0045109

intermediate filament organization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

P

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

C

Seeded From UniProt

complete

involved_in

GO:0008544

epidermis development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

P

Seeded From UniProt

complete

enables

GO:0008092

cytoskeletal protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

F

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

F

Seeded From UniProt

complete

involved_in

GO:0003334

keratinocyte development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q3TTY5
ensembl:ENSMUSP00000023712

P

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003054

C

Seeded From UniProt

complete

involved_in

GO:0008544

epidermis development

PMID:7524919[9]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:1380918[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:1380918[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

Reactome:R-HSA-6809371

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

Reactome:R-HSA-6805567

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8942224
Reactome:R-HSA-6814764
Reactome:R-HSA-6814734
Reactome:R-HSA-6814387
Reactome:R-HSA-6814298
Reactome:R-HSA-6811539
Reactome:R-HSA-6810937
Reactome:R-HSA-6810357
Reactome:R-HSA-6809663
Reactome:R-HSA-6809393
Reactome:R-HSA-6806629
Reactome:R-HSA-6806613
Reactome:R-HSA-6806610
Reactome:R-HSA-6805573
Reactome:R-HSA-6805546

ECO:0000304

author statement supported by traceable reference used in manual assertion















C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0403
UniProtKB-KW:KW-0416

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Steinert, PM & Marekov, LN (1995) The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J. Biol. Chem. 270 17702-11 PubMed GONUTS page
  2. ↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
  3. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  4. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  5. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  6. ↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
  7. ↑ Lan, L et al. (2005) Suprabasal induction of ornithine decarboxylase in adult mouse skin is sufficient to activate keratinocytes. J. Invest. Dermatol. 124 602-14 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 Bloor, BK et al. (2003) Expression of keratin K2e in cutaneous and oral lesions: association with keratinocyte activation, proliferation, and keratinization. Am. J. Pathol. 162 963-75 PubMed GONUTS page
  9. ↑ Rothnagel, JA et al. (1994) Mutations in the rod domain of keratin 2e in patients with ichthyosis bullosa of Siemens. Nat. Genet. 7 485-90 PubMed GONUTS page
  10. ↑ 10.0 10.1 Collin, C et al. (1992) Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation. Exp. Cell Res. 202 132-41 PubMed GONUTS page
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