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HUMAN:K1C14

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) KRT14
Protein Name(s) Keratin, type I cytoskeletal 14

Cytokeratin-14 CK-14 Keratin-14 K14

External Links
UniProt P02533
EMBL J00124
BT007186
AC019349
BC002690
BC019097
BC042437
BC094830
D28807
AF186085
AF186086
AF186087
AF186088
AF186089
AF186090
CCDS CCDS11400.1
PIR A26763
RefSeq NP_000517.2
UniGene Hs.654380
PDB 3TNU
PDBsum 3TNU
ProteinModelPortal P02533
SMR P02533
BioGrid 110059
DIP DIP-33874N
IntAct P02533
STRING 9606.ENSP00000167586
PhosphoSite P02533
DMDM 229463044
MaxQB P02533
PaxDb P02533
PRIDE P02533
DNASU 3861
Ensembl ENST00000167586
GeneID 3861
KEGG hsa:3861
UCSC uc002hxf.2
CTD 3861
GeneCards GC17M039738
GeneReviews KRT14
HGNC HGNC:6416
HPA CAB000134
HPA000452
HPA000453
HPA023040
MIM 125595
131760
131800
131900
148066
161000
601001
neXtProt NX_P02533
Orphanet 89838
86920
79397
79396
79399
79400
69087
PharmGKB PA30203
eggNOG NOG148784
GeneTree ENSGT00760000118808
HOVERGEN HBG013015
InParanoid P02533
KO K07604
OMA VSTHEQI
OrthoDB EOG7FV3Q8
PhylomeDB P02533
TreeFam TF332742
Reactome REACT_20537
GeneWiki Keratin_14
GenomeRNAi 3861
NextBio 15195
PRO PR:P02533
Proteomes UP000005640
Bgee P02533
CleanEx HS_KRT14
ExpressionAtlas P02533
Genevestigator P02533
GO GO:0071944
GO:0005737
GO:0005829
GO:0070062
GO:0005882
GO:0045095
GO:0005634
GO:1990254
GO:0005200
GO:0007568
GO:0034329
GO:0008544
GO:0030855
GO:0042633
GO:0031581
GO:0045110
GO:0010212
GO:0010043
InterPro IPR001664
IPR018039
IPR002957
IPR009053
PANTHER PTHR23239
Pfam PF00038
PRINTS PR01248
SUPFAM SSF46579
PROSITE PS00226

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:1990254

keratin filament binding

PMID:20346438[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q7RTS7

F

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:19199708[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001831)

Seeded From UniProt

complete

involved_in

GO:0042633

hair cycle

PMID:21916889[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007568

aging

PMID:21916889[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:20346438[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21630459[4]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000019)

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

PMID:10852826[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045110

intermediate filament bundle assembly

PMID:11724817[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11724817[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:11724817[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

PMID:7679677[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61781
ensembl:ENSMUSP00000007272

C

Seeded From UniProt

complete

part_of

GO:0045178

basal part of cell

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61781
ensembl:ENSMUSP00000007272

C

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61781
ensembl:ENSMUSP00000007272

C

Seeded From UniProt

complete

involved_in

GO:0030855

epithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61781
ensembl:ENSMUSP00000007272

P

Seeded From UniProt

complete

part_of

GO:0045095

keratin filament

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6IFV1
ensembl:ENSRNOP00000005285

C

Seeded From UniProt

complete

involved_in

GO:0030855

epithelial cell differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6IFV1
ensembl:ENSRNOP00000005285

P

Seeded From UniProt

complete

involved_in

GO:0010212

response to ionizing radiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6IFV1
ensembl:ENSRNOP00000005285

P

Seeded From UniProt

complete

involved_in

GO:0010043

response to zinc ion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q6IFV1
ensembl:ENSRNOP00000005285

P

Seeded From UniProt

complete

enables

GO:0005198

structural molecule activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664
InterPro:IPR002957

F

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001664

C

Seeded From UniProt

complete

involved_in

GO:0008544

epidermis development

PMID:7525408[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005200

structural constituent of cytoskeleton

PMID:7525408[8]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070268

cornification

Reactome:R-HSA-6809371

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031581

hemidesmosome assembly

Reactome:R-HSA-446107

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031424

keratinization

Reactome:R-HSA-6805567

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8942224
Reactome:R-HSA-6814764
Reactome:R-HSA-6814734
Reactome:R-HSA-6814387
Reactome:R-HSA-6814298
Reactome:R-HSA-6811539
Reactome:R-HSA-6810937
Reactome:R-HSA-6810357
Reactome:R-HSA-6809663
Reactome:R-HSA-6809393
Reactome:R-HSA-6806629
Reactome:R-HSA-6806613
Reactome:R-HSA-6806610
Reactome:R-HSA-6805573
Reactome:R-HSA-6805546
Reactome:R-HSA-446077

ECO:0000304

author statement supported by traceable reference used in manual assertion
















C

Seeded From UniProt

complete

part_of

GO:0005882

intermediate filament

GO_REF:0000037
GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0416
UniProtKB-KW:KW-0403

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Shimomura, Y et al. (2010) Autosomal-dominant woolly hair resulting from disruption of keratin 74 (KRT74), a potential determinant of human hair texture. Am. J. Hum. Genet. 86 632-8 PubMed GONUTS page
  2. ↑ Gonzalez-Begne, M et al. (2009) Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J. Proteome Res. 8 1304-14 PubMed GONUTS page
  3. ↑ 3.0 3.1 Choi, HI et al. (2011) Hair greying is associated with active hair growth. Br. J. Dermatol. 165 1183-9 PubMed GONUTS page
  4. ↑ de Mateo, S et al. (2011) Proteomic characterization of the human sperm nucleus. Proteomics 11 2714-26 PubMed GONUTS page
  5. ↑ Hofmann, I et al. (2000) Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. J. Cell. Sci. 113 ( Pt 13) 2471-83 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 Bousquet, O et al. (2001) The nonhelical tail domain of keratin 14 promotes filament bundling and enhances the mechanical properties of keratin intermediate filaments in vitro. J. Cell Biol. 155 747-54 PubMed GONUTS page
  7. ↑ Kartasova, T et al. (1993) Mouse differentiation-specific keratins 1 and 10 require a preexisting keratin scaffold to form a filament network. J. Cell Biol. 120 1251-61 PubMed GONUTS page
  8. ↑ 8.0 8.1 Chan, Y et al. (1994) A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein. Genes Dev. 8 2574-87 PubMed GONUTS page
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