HUMAN:JAK3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	JAK3
Protein Name(s)	Tyrosine-protein kinase JAK3 Janus kinase 3 JAK-3 Leukocyte janus kinase L-JAK
External Links
UniProt	P52333
EMBL	U09607 U31601 U31602 U70065 AF513860 AC007201 CH471106 BC028068 U57096
CCDS	CCDS12366.1
PIR	A55747
RefSeq	NP_000206.2 XP_006722808.1
UniGene	Hs.515247
PDB	1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q
PDBsum	1YVJ 3LXK 3LXL 3PJC 3ZC6 3ZEP 4HVD 4HVG 4HVH 4HVI 4I6Q
ProteinModelPortal	P52333
SMR	P52333
BioGrid	109921
DIP	DIP-274N
IntAct	P52333
MINT	MINT-1497014
STRING	9606.ENSP00000391676
BindingDB	P52333
ChEMBL	CHEMBL3038491
DrugBank	DB08895
GuidetoPHARMACOLOGY	2049
PhosphoSite	P52333
DMDM	50403745
MaxQB	P52333
PaxDb	P52333
PRIDE	P52333
DNASU	3718
Ensembl	ENST00000458235 ENST00000527670 ENST00000534444 ENST00000613342
GeneID	3718
KEGG	hsa:3718
UCSC	uc002nhn.4 uc002nho.2 uc010xpx.1
CTD	3718
GeneCards	GC19M017935
HGNC	HGNC:6193
MIM	600173 600802
neXtProt	NX_P52333
Orphanet	35078
PharmGKB	PA29990
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000049158
HOVERGEN	HBG006195
InParanoid	P52333
KO	K11218
OMA	IAWTQGE
OrthoDB	EOG7BW0HM
PhylomeDB	P52333
TreeFam	TF327041
BRENDA	2.7.10.2
Reactome	REACT_115529 REACT_1695 REACT_19290 REACT_23891 REACT_27283
SignaLink	P52333
EvolutionaryTrace	P52333
GeneWiki	Janus_kinase_3
GenomeRNAi	3718
NextBio	14571
PRO	PR:P52333
Proteomes	UP000005640
Bgee	P52333
CleanEx	HS_JAK3
ExpressionAtlas	P52333
Genevestigator	P52333
GO	GO:0005856 GO:0005829 GO:0012505 GO:0016020 GO:0005524 GO:0004715 GO:0019903 GO:0004713 GO:0030183 GO:0007167 GO:0045087 GO:0035771 GO:0035556 GO:0060397 GO:0002731 GO:0045221 GO:0032693 GO:0032695 GO:0050868 GO:0045626 GO:0070244 GO:0018108 GO:2000670 GO:2001241 GO:0045944 GO:0006468 GO:0070232 GO:0070672 GO:0070669 GO:0070670 GO:0071104 GO:0007262 GO:0043029 GO:0007260
Gene3D	3.30.505.10
InterPro	IPR019749 IPR000299 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR016251 IPR020775
Pfam	PF07714
PIRSF	PIRSF000636
PRINTS	PR01823 PR01826 PR00109
SMART	SM00295 SM00252 SM00219
SUPFAM	SSF55550 SSF56112
PROSITE	PS50057 PS00107 PS50011 PS00109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0070670	response to interleukin-4	PMID:7594533^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070670	response to interleukin-4	PMID:7538655^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070244	negative regulation of thymocyte apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0070232	regulation of T cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0050868	negative regulation of T cell activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0045626	negative regulation of T-helper 1 cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0045221	negative regulation of FasL biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0035771	interleukin-4-mediated signaling pathway	PMID:7538655^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0032695	negative regulation of interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0032693	negative regulation of interleukin-10 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
involved_in	GO:0007167	enzyme linked receptor protein signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	F	Seeded From UniProt	complete
involved_in	GO:0002731	negative regulation of dendritic cell cytokine production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62137	P	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:11909529^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17706	F	Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99928 PANTHER:PTN000700628	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700628 RGD:2940	P	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 PANTHER:PTN002401049	P	Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99928 PANTHER:PTN000700628	P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 MGI:MGI:99928 PANTHER:PTN002401049 RGD:2940 UniProtKB:O60674	P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 PANTHER:PTN002401049 RGD:2939	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020775	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016251 InterPro:IPR017441 InterPro:IPR020775	F	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016251 InterPro:IPR020635 InterPro:IPR020775	P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020775	C	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020775	P	Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8022790^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8022790^[5] Reactome:R-HSA-451942	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071104	response to interleukin-9	PMID:7594533^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070672	response to interleukin-15	PMID:7594533^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070669	response to interleukin-2	PMID:9973401^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	PMID:19290934^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	PMID:19290934^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	PMID:19290934^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:19290934^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038114	interleukin-21-mediated signaling pathway	Reactome:R-HSA-9020958	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038113	interleukin-9-mediated signaling pathway	Reactome:R-HSA-8985947	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038111	interleukin-7-mediated signaling pathway	Reactome:R-HSA-1266695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035723	interleukin-15-mediated signaling pathway	Reactome:R-HSA-8983432	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-8985988 Reactome:R-HSA-8985973 Reactome:R-HSA-8985929 Reactome:R-HSA-8985914 Reactome:R-HSA-8985900	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-919404 Reactome:R-HSA-913424 Reactome:R-HSA-913374 Reactome:R-HSA-912527 Reactome:R-HSA-9025969 Reactome:R-HSA-9006873 Reactome:R-HSA-9006870 Reactome:R-HSA-9006850 Reactome:R-HSA-9006844 Reactome:R-HSA-8985914 Reactome:R-HSA-8983384 Reactome:R-HSA-8983378 Reactome:R-HSA-8983374 Reactome:R-HSA-8983371 Reactome:R-HSA-8983335 Reactome:R-HSA-8983300 Reactome:R-HSA-8983298 Reactome:R-HSA-8983063 Reactome:R-HSA-8983003 Reactome:R-HSA-8963734 Reactome:R-HSA-6786124 Reactome:R-HSA-6786096 Reactome:R-HSA-6786095 Reactome:R-HSA-6786092 Reactome:R-HSA-6786072 Reactome:R-HSA-6786058 Reactome:R-HSA-6785165 Reactome:R-HSA-5672965 Reactome:R-HSA-508513 Reactome:R-HSA-508451 Reactome:R-HSA-508292 Reactome:R-HSA-508282 Reactome:R-HSA-508247 Reactome:R-HSA-453111 Reactome:R-HSA-453104 Reactome:R-HSA-452122 Reactome:R-HSA-452108 Reactome:R-HSA-452100 Reactome:R-HSA-452097 Reactome:R-HSA-452091 Reactome:R-HSA-451942 Reactome:R-HSA-451895 Reactome:R-HSA-450063 Reactome:R-HSA-449958 Reactome:R-HSA-449115 Reactome:R-HSA-1295540	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005768	endosome	Reactome:R-HSA-8983335	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Tortolani, PJ et al. (1995) Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J. Immunol. 155 5220-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Rolling, C et al. (1995) JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering. Oncogene 10 1757-61 PubMed GONUTS page
↑ Simoncic, PD et al. (2002) The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12 446-53 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Kawamura, M et al. (1994) Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. U.S.A. 91 6374-8 PubMed GONUTS page
↑ Eynon, EE et al. (1999) Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J. Immunol. 162 1448-59 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Ghoreschi, K et al. (2009) Janus kinases in immune cell signaling. Immunol. Rev. 228 273-87 PubMed GONUTS page

[PMID:7594533-1] 1.0 ^1.1 ^1.2 Tortolani, PJ et al. (1995) Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J. Immunol. 155 5220-6 PubMed GONUTS page

[PMID:7538655-2] 2.0 ^2.1 Rolling, C et al. (1995) JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering. Oncogene 10 1757-61 PubMed GONUTS page

[PMID:11909529-3] Simoncic, PD et al. (2002) The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr. Biol. 12 446-53 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8022790-5] 5.0 ^5.1 Kawamura, M et al. (1994) Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes. Proc. Natl. Acad. Sci. U.S.A. 91 6374-8 PubMed GONUTS page

[PMID:9973401-6] Eynon, EE et al. (1999) Distinct effects of Jak3 signaling on alphabeta and gammadelta thymocyte development. J. Immunol. 162 1448-59 PubMed GONUTS page

[PMID:19290934-7] 7.0 ^7.1 ^7.2 ^7.3 Ghoreschi, K et al. (2009) Janus kinases in immune cell signaling. Immunol. Rev. 228 273-87 PubMed GONUTS page

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HUMAN:JAK3

Contents

Annotations

Notes

References

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