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HUMAN:ITSN2
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ITSN2 (synonyms: KIAA1256, SH3D1B, SWAP) | |
| Protein Name(s) | Intersectin-2
SH3 domain-containing protein 1B SH3P18 SH3P18-like WASP-associated protein | |
| External Links | ||
| UniProt | Q9NZM3 | |
| EMBL | AF182198 AF182199 AF248540 AB033082 AC008073 AC009228 AK021545 AK000302 AF001630 U61167 | |
| CCDS | CCDS1710.2 CCDS1711.2 CCDS46230.1 | |
| RefSeq | NP_006268.2 NP_062541.3 NP_671494.2 | |
| UniGene | Hs.432562 | |
| PDB | 1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO | |
| PDBsum | 1J3T 1UDL 1UE9 1UFF 1UHF 3GF9 3JZY 4IIO | |
| ProteinModelPortal | Q9NZM3 | |
| SMR | Q9NZM3 | |
| BioGrid | 119098 | |
| IntAct | Q9NZM3 | |
| MINT | MINT-1404321 | |
| STRING | 9606.ENSP00000347244 | |
| PhosphoSite | Q9NZM3 | |
| DMDM | 294862505 | |
| MaxQB | Q9NZM3 | |
| PaxDb | Q9NZM3 | |
| PRIDE | Q9NZM3 | |
| Ensembl | ENST00000355123 ENST00000361999 ENST00000406921 | |
| GeneID | 50618 | |
| KEGG | hsa:50618 | |
| UCSC | uc002rfe.2 uc002rff.2 uc002rfg.3 | |
| CTD | 50618 | |
| GeneCards | GC02M024425 | |
| H-InvDB | HIX0001876 | |
| HGNC | HGNC:6184 | |
| HPA | HPA036475 | |
| MIM | 604464 | |
| neXtProt | NX_Q9NZM3 | |
| PharmGKB | PA29982 | |
| eggNOG | COG5422 | |
| GeneTree | ENSGT00760000118985 | |
| HOVERGEN | HBG052159 | |
| InParanoid | Q9NZM3 | |
| OMA | WQQKSAF | |
| OrthoDB | EOG7WMCJ3 | |
| PhylomeDB | Q9NZM3 | |
| TreeFam | TF324293 | |
| ChiTaRS | ITSN2 | |
| EvolutionaryTrace | Q9NZM3 | |
| GeneWiki | ITSN2 | |
| GenomeRNAi | 50618 | |
| NextBio | 53140 | |
| PRO | PR:Q9NZM3 | |
| Proteomes | UP000005640 | |
| Bgee | Q9NZM3 | |
| CleanEx | HS_ITSN2 | |
| ExpressionAtlas | Q9NZM3 | |
| Genevestigator | Q9NZM3 | |
| GO | GO:0005737 GO:0070062 GO:0005509 GO:0005089 GO:0005070 GO:0006897 GO:0009967 | |
| Gene3D | 1.10.238.10 1.20.900.10 2.30.29.30 2.60.40.150 | |
| InterPro | IPR000008 IPR000219 IPR011992 IPR018247 IPR002048 IPR000261 IPR027029 IPR001849 IPR011993 IPR011511 IPR001452 | |
| PANTHER | PTHR11216:SF29 | |
| Pfam | PF00168 PF00621 PF00018 PF07653 PF14604 | |
| PRINTS | PR00452 | |
| SMART | SM00239 SM00054 SM00027 SM00233 SM00325 SM00326 | |
| SUPFAM | SSF48065 SSF49562 SSF50044 | |
| PROSITE | PS50004 PS50010 PS00018 PS50222 PS50031 PS50003 PS50002 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0005813 |
centrosome |
ECO:0000314 |
C |
Figure 2B. |
complete | |||||
|
involved_in |
GO:1903861 |
positive regulation of dendrite extension |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000148) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005813 |
centrosome |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0070062 |
extracellular exosome |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(UBERON:0001088) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0009967 |
positive regulation of signal transduction |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005070 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005509 |
calcium ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035023 |
regulation of Rho protein signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005070 |
SH3/SH2 adaptor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006897 |
endocytosis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030154 |
cell differentiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Rodriguez-Fraticelli, AE et al. (2010) The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J. Cell Biol. 189 725-38 PubMed GONUTS page
- ↑ Yoo, JC et al. (2013) SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation. J. Dermatol. Sci. 72 246-51 PubMed GONUTS page
- ↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
- ↑ Sparks, AB et al. (1996) Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat. Biotechnol. 14 741-4 PubMed GONUTS page
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