HUMAN:IRS2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IRS2
Protein Name(s)	Insulin receptor substrate 2 IRS-2
External Links
UniProt	Q9Y4H2
EMBL	AB000732 AF073310 AF322115 AF322114 AL162497 AF288517
CCDS	CCDS9510.1
RefSeq	NP_003740.2
UniGene	Hs.442344
PDB	3FQW 3FQX
PDBsum	3FQW 3FQX
ProteinModelPortal	Q9Y4H2
SMR	Q9Y4H2
BioGrid	114209
IntAct	Q9Y4H2
MINT	MINT-156306
STRING	9606.ENSP00000365016
PhosphoSite	Q9Y4H2
BioMuta	IRS2
DMDM	62298062
MaxQB	Q9Y4H2
PaxDb	Q9Y4H2
PRIDE	Q9Y4H2
DNASU	8660
Ensembl	ENST00000375856
GeneID	8660
KEGG	hsa:8660
UCSC	uc001vqv.3
CTD	8660
GeneCards	GC13M110406
HGNC	HGNC:6126
HPA	CAB016944 HPA054664
MIM	600797
neXtProt	NX_Q9Y4H2
PharmGKB	PA375
eggNOG	NOG81285
GeneTree	ENSGT00530000063420
HOVERGEN	HBG000542
InParanoid	Q9Y4H2
KO	K07187
OMA	WYRALTD
OrthoDB	EOG7XM2X6
PhylomeDB	Q9Y4H2
TreeFam	TF325994
Reactome	REACT_111133 REACT_12464 REACT_147727 REACT_150203 REACT_169118 REACT_508 REACT_524 REACT_570 REACT_75829 REACT_976
SignaLink	Q9Y4H2
ChiTaRS	IRS2
EvolutionaryTrace	Q9Y4H2
GeneWiki	IRS2
GenomeRNAi	8660
NextBio	32479
PMAP-CutDB	Q9Y4H2
PRO	PR:Q9Y4H2
Proteomes	UP000005640
Bgee	Q9Y4H2
CleanEx	HS_IRS2
Genevisible	Q9Y4H2
GO	GO:0005829 GO:0005886 GO:0005158 GO:0043548 GO:0004871 GO:0007420 GO:0008283 GO:0071333 GO:0032869 GO:0007173 GO:0038095 GO:0008543 GO:0006006 GO:0045087 GO:0008286 GO:0060397 GO:0055088 GO:0030879 GO:0002903 GO:0033673 GO:0010748 GO:0048011 GO:0048015 GO:0030890 GO:0030335 GO:0008284 GO:0032000 GO:0046326 GO:0010907 GO:0045725 GO:0032024 GO:0002053 GO:0019216 GO:0009749 GO:0007165
Gene3D	2.30.29.30
InterPro	IPR002404 IPR011993 IPR001849
Pfam	PF02174 PF00169
PRINTS	PR00628
SMART	SM00233 SM00310
PROSITE	PS51064 PS50003

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004871	signal transducer activity		ECO:0000304			F	Source: ProtInc	Missing: reference
	GO:0006006	glucose metabolic process		ECO:0000304			P	Source: ProtInc	Missing: reference
involved_in	GO:0046326	positive regulation of glucose import	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:17925406^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P81122	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P81122	P	Seeded From UniProt	complete
involved_in	GO:0032000	positive regulation of fatty acid beta-oxidation	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P81122	P	Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	PMID:16814735^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P81122	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O70360	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:17925406^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002903	negative regulation of B cell apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P81122	P	Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109334 MGI:MGI:1194882 MGI:MGI:99454 PANTHER:PTN000064809 RGD:2922 RGD:69316 UniProtKB:P35568	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024248 MGI:MGI:109334 PANTHER:PTN000064809 RGD:2922 RGD:69316 UniProtKB:P35568	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109334 MGI:MGI:1194882 MGI:MGI:99454 PANTHER:PTN000064809 RGD:2922 RGD:69317 UniProtKB:P35568	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024248 MGI:MGI:109334 PANTHER:PTN000064809 RGD:2922 RGD:69317 UniProtKB:P35568	C	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024248 PANTHER:PTN000064809 RGD:2922 RGD:69316 UniProtKB:P35568	F	Seeded From UniProt	complete
involved_in	GO:1901653	cellular response to peptide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	P	Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	F	Seeded From UniProt	complete
involved_in	GO:0071333	cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	P	Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	F	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	P	Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	F	Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	P	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1MAL5 ensembl:ENSRNOP00000036862	F	Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	F	Seeded From UniProt	complete
involved_in	GO:0033673	negative regulation of kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	C	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	F	Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	C	Seeded From UniProt	complete
involved_in	GO:0002903	negative regulation of B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P81122 ensembl:ENSMUSP00000038514	P	Seeded From UniProt	complete
enables	GO:0005158	insulin receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039011	F	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039011	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:7675087^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	PMID:9495343^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0055088	lipid homeostasis	PMID:16814735^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019216	regulation of lipid metabolic process	PMID:16814735^[1]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	Reactome:R-HSA-2316434	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0048015	phosphatidylinositol-mediated signaling	Reactome:R-HSA-198203	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	Reactome:R-HSA-9027284	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038111	interleukin-7-mediated signaling pathway	Reactome:R-HSA-1266695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-9027276	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-2428926 Reactome:R-HSA-2428922 Reactome:R-HSA-2400009 Reactome:R-HSA-2316434 Reactome:R-HSA-198266	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9029150 Reactome:R-HSA-9027281 Reactome:R-HSA-9027275 Reactome:R-HSA-9027273 Reactome:R-HSA-9027272 Reactome:R-HSA-9021627 Reactome:R-HSA-9012657 Reactome:R-HSA-8983003 Reactome:R-HSA-8855915 Reactome:R-HSA-74747 Reactome:R-HSA-74737 Reactome:R-HSA-74736 Reactome:R-HSA-74712 Reactome:R-HSA-74711 Reactome:R-HSA-74707 Reactome:R-HSA-5686315 Reactome:R-HSA-5672965 Reactome:R-HSA-2428922 Reactome:R-HSA-198315 Reactome:R-HSA-109823 Reactome:R-HSA-109699	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0807	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page
↑ ^2.0 ^2.1 Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sun, XJ et al. (1995) Role of IRS-2 in insulin and cytokine signalling. Nature 377 173-7 PubMed GONUTS page
↑ Withers, DJ et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391 900-4 PubMed GONUTS page

[PMID:16814735-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page

[PMID:17925406-2] 2.0 ^2.1 Jensen, M et al. (2007) Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses. J. Biol. Chem. 282 35179-86 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7675087-4] Sun, XJ et al. (1995) Role of IRS-2 in insulin and cytokine signalling. Nature 377 173-7 PubMed GONUTS page

[PMID:9495343-5] Withers, DJ et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391 900-4 PubMed GONUTS page

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HUMAN:IRS2

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