HUMAN:IPSP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SERPINA5 (synonyms: PCI, PLANH3, PROCI)
Protein Name(s)	Plasma serine protease inhibitor Acrosomal serine protease inhibitor Plasminogen activator inhibitor 3 PAI-3 PAI3 Protein C inhibitor PCI Serpin A5
External Links
UniProt	P05154
EMBL	J02639 M68516 S69366 S69364 S69574 S69365 U35464 AF361796 AL049839 BC008915 S58545 AL080185
CCDS	CCDS9928.1
PIR	A39339
RefSeq	NP_000615.3
UniGene	Hs.159628 Hs.741309
PDB	1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
PDBsum	1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
ProteinModelPortal	P05154
SMR	P05154
BioGrid	111135
DIP	DIP-29869N
IntAct	P05154
MINT	MINT-1386269
STRING	9606.ENSP00000333203
DrugBank	DB00055 DB00013
MEROPS	I04.004
PhosphoSite	P05154
DMDM	322510122
MaxQB	P05154
PaxDb	P05154
PRIDE	P05154
DNASU	5104
Ensembl	ENST00000329597 ENST00000553780 ENST00000554276 ENST00000554866
GeneID	5104
KEGG	hsa:5104
UCSC	uc001ydm.3
CTD	5104
GeneCards	GC14P095047
H-InvDB	HIX0079547
HGNC	HGNC:8723
HPA	HPA056919 HPA061957
MIM	601841
neXtProt	NX_P05154
eggNOG	COG4826
GeneTree	ENSGT00760000118839
HOGENOM	HOG000238521
HOVERGEN	HBG005957
InParanoid	P05154
KO	K03913
OMA	QRIVFNR
PhylomeDB	P05154
TreeFam	TF343201
Reactome	REACT_1439 REACT_326
ChiTaRS	SERPINA5
EvolutionaryTrace	P05154
GeneWiki	Protein_C_inhibitor
GenomeRNAi	5104
NextBio	19698
PMAP-CutDB	P05154
PRO	PR:P05154
Proteomes	UP000005640
Bgee	P05154
CleanEx	HS_SERPINA5
ExpressionAtlas	P05154
Genevestigator	P05154
GO	GO:0002080 GO:0009897 GO:0005576 GO:0005615 GO:0070062 GO:0016020 GO:0031091 GO:0031094 GO:0097181 GO:0097182 GO:0097183 GO:0036029 GO:0036030 GO:0036026 GO:0036027 GO:0036028 GO:0036025 GO:0036024 GO:0043234 GO:0032190 GO:0005539 GO:0008201 GO:0031210 GO:0002020 GO:0001972 GO:0004867 GO:0007342 GO:0006869 GO:0010951 GO:0030162 GO:0007283
InterPro	IPR023795 IPR023796 IPR000215
PANTHER	PTHR11461
Pfam	PF00079
SMART	SM00093
SUPFAM	SSF56574
PROSITE	PS00284

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	PMID:28327460^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002570)	Seeded From UniProt	complete
involved_in	GO:0051346	negative regulation of hydrolase activity	PMID:8665956^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P07288)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:8665956^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0006530)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8665956^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001969)	Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:8665956^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07288	F		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0097183	protein C inhibitor-coagulation factor XI complex	PMID:2844223^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097182	protein C inhibitor-coagulation factor Xa complex	PMID:6323392^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0097181	protein C inhibitor-coagulation factor V complex	PMID:6323392^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21557262^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:7521127^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036030	protein C inhibitor-plasma kallikrein complex	PMID:8536714^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036030	protein C inhibitor-plasma kallikrein complex	PMID:2844223^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036029	protein C inhibitor-KLK3 complex	PMID:1725227^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036028	protein C inhibitor-thrombin complex	PMID:6323392^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036027	protein C inhibitor-PLAU complex	PMID:8536714^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036027	protein C inhibitor-PLAU complex	PMID:10340997^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036027	protein C inhibitor-PLAU complex	PMID:3501295^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036026	protein C inhibitor-PLAT complex	PMID:10340997^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036025	protein C inhibitor-TMPRSS11E complex	PMID:15328353^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0036024	protein C inhibitor-TMPRSS7 complex	PMID:15853774^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0032190	acrosin binding	PMID:7521127^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10323	F		Seeded From UniProt	complete
enables	GO:0031210	phosphatidylcholine binding	PMID:9556620^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031094	platelet dense tubular network	PMID:9556620^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031091	platelet alpha granule	PMID:9556620^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7521127^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:9556620^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007342	fusion of sperm to egg plasma membrane involved in single fertilization	PMID:9510955^[16]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P70458	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10340997^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8536714^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1725227^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:14718574^[17]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:15853774^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:10340997^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:9510955^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:2844223^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:3501295^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:9556620^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:8536714^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:1725227^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:6323392^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:7521127^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:9510955^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0002080	acrosomal membrane	PMID:7521127^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:14696115^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00749	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:9556620^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12259	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:7521127^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10323	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:1725227^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P07288	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:2844223^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03952	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:2844223^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12259	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:2844223^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03951	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:3501295^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00749	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:6323392^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00742	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:6323392^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00734	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:6323392^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P12259	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:10340997^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00749	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:10340997^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P00750	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:15853774^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BIK6	F		Seeded From UniProt	complete
enables	GO:0001972	retinoic acid binding	PMID:11722589^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0028988 FB:FBgn0265137 PANTHER:PTN000156123 RGD:3249 UniProtKB:P05121 UniProtKB:P29508 UniProtKB:P35237 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q9UIV8	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0015586 FB:FBgn0028986 FB:FBgn0031973 FB:FBgn0262057 FB:FBgn0265137 MGI:MGI:108080 MGI:MGI:1915304 MGI:MGI:87963 MGI:MGI:88278 MGI:MGI:894696 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:2069 RGD:3249 RGD:3326 RGD:3747 RGD:3748 RGD:619833 RGD:631369 RGD:735225 UniProtKB:P01008 UniProtKB:P01009 UniProtKB:P01011 UniProtKB:P01019 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P08697 UniProtKB:P50453 UniProtKB:Q90935 UniProtKB:Q99574 UniProtKB:Q9TTE1	C		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002930 FB:FBgn0028983 FB:FBgn0028988 FB:FBgn0028990 FB:FBgn0265137 MGI:MGI:101780 MGI:MGI:106603 MGI:MGI:1277952 MGI:MGI:2445361 MGI:MGI:2683293 MGI:MGI:891970 MGI:MGI:894696 MGI:MGI:97608 PANTHER:PTN000156123 RGD:1306692 RGD:1307404 RGD:3249 RGD:3326 RGD:3748 RGD:619817 RGD:619896 RGD:619897 UniProtKB:P01009 UniProtKB:P01012 UniProtKB:P05121 UniProtKB:P05154 UniProtKB:P05155 UniProtKB:P07093 UniProtKB:P08697 UniProtKB:P35237 UniProtKB:P48594 UniProtKB:P50452 UniProtKB:P50453 UniProtKB:Q3ZEJ6 UniProtKB:Q86WD7 UniProtKB:Q90935 UniProtKB:Q96P63 UniProtKB:Q99574 UniProtKB:Q9TTE1 UniProtKB:Q9UIV8 WB:WBGene00005643	F		Seeded From UniProt	complete
involved_in	GO:0061107	seminal vesicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7EMJ6 ensembl:ENSRNOP00000013138	P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7EMJ6 ensembl:ENSRNOP00000013138	P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F7EMJ6 ensembl:ENSRNOP00000013138	F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70458 ensembl:ENSMUSP00000021495	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000215	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	PMID:11120760^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:11120760^[21] Reactome:R-HSA-5591086	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005539	glycosaminoglycan binding	PMID:8796266^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-140875	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030414	peptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	F		Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0278	P		Seeded From UniProt	complete
involved_in	GO:0006869	lipid transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0445	P		Seeded From UniProt	complete
enables	GO:0004867	serine-type endopeptidase inhibitor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0722	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
involved_in	GO:0010466	negative regulation of peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0646	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0112	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Kise, H et al. (1996) Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur. J. Biochem. 238 88-96 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Meijers, JC et al. (1988) Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. Biochemistry 27 4231-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Suzuki, K et al. (1984) Mechanism of inhibition of activated protein C by protein C inhibitor. J. Biochem. 95 187-95 PubMed GONUTS page
↑ Li, Y et al. (2011) Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 32 1976-83 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Zheng, X et al. (1994) Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. Am. J. Physiol. 267 C466-72 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 España, F et al. (1995) Complexes of tissue kallikrein with protein C inhibitor in human semen and urine. Eur. J. Biochem. 234 641-9 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 España, F et al. (1991) Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb. Res. 64 309-20 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 He, S et al. (1999) Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. Mol. Hum. Reprod. 5 513-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Stief, TW et al. (1987) Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3. Biol. Chem. Hoppe-Seyler 368 1427-33 PubMed GONUTS page
↑ Hobson, JP et al. (2004) Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J. Biol. Chem. 279 46981-94 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Szabo, R et al. (2005) Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem. J. 390 231-42 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Nishioka, J et al. (1998) Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles. J. Biol. Chem. 273 11281-7 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Elisen, MG et al. (1998) Protein C inhibitor may modulate human sperm-oocyte interactions. Biol. Reprod. 58 670-7 PubMed GONUTS page
↑ Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page
↑ Wakita, T et al. (2004) Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. Int. J. Cancer 108 516-23 PubMed GONUTS page
↑ Jerabek, I et al. (2001) Binding of retinoic acid by the inhibitory serpin protein C inhibitor. Eur. J. Biochem. 268 5989-96 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^21.0 ^21.1 Uhrin, P et al. (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J. Clin. Invest. 106 1531-9 PubMed GONUTS page
↑ Geiger, M et al. (1996) Protein C inhibitor (PCI). Immunopharmacology 32 53-6 PubMed GONUTS page

[PMID:28327460-1] Ragelle, H et al. (2017) Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials 128 147-159 PubMed GONUTS page

[PMID:8665956-2] 2.0 ^2.1 ^2.2 ^2.3 Kise, H et al. (1996) Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. Eur. J. Biochem. 238 88-96 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19056867-4] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:2844223-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Meijers, JC et al. (1988) Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor. Biochemistry 27 4231-7 PubMed GONUTS page

[PMID:6323392-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Suzuki, K et al. (1984) Mechanism of inhibition of activated protein C by protein C inhibitor. J. Biochem. 95 187-95 PubMed GONUTS page

[PMID:21557262-7] Li, Y et al. (2011) Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 32 1976-83 PubMed GONUTS page

[PMID:7521127-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Zheng, X et al. (1994) Inhibition of acrosin by protein C inhibitor and localization of protein C inhibitor to spermatozoa. Am. J. Physiol. 267 C466-72 PubMed GONUTS page

[PMID:8536714-9] 9.0 ^9.1 ^9.2 ^9.3 España, F et al. (1995) Complexes of tissue kallikrein with protein C inhibitor in human semen and urine. Eur. J. Biochem. 234 641-9 PubMed GONUTS page

[PMID:1725227-10] 10.0 ^10.1 ^10.2 ^10.3 España, F et al. (1991) Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen. Thromb. Res. 64 309-20 PubMed GONUTS page

[PMID:10340997-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 He, S et al. (1999) Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility. Mol. Hum. Reprod. 5 513-9 PubMed GONUTS page

[PMID:3501295-12] 12.0 ^12.1 ^12.2 Stief, TW et al. (1987) Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3. Biol. Chem. Hoppe-Seyler 368 1427-33 PubMed GONUTS page

[PMID:15328353-13] Hobson, JP et al. (2004) Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J. Biol. Chem. 279 46981-94 PubMed GONUTS page

[PMID:15853774-14] 14.0 ^14.1 ^14.2 Szabo, R et al. (2005) Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity. Biochem. J. 390 231-42 PubMed GONUTS page

[PMID:9556620-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 Nishioka, J et al. (1998) Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles. J. Biol. Chem. 273 11281-7 PubMed GONUTS page

[PMID:9510955-16] 16.0 ^16.1 ^16.2 Elisen, MG et al. (1998) Protein C inhibitor may modulate human sperm-oocyte interactions. Biol. Reprod. 58 670-7 PubMed GONUTS page

[PMID:14718574-17] Anderson, NL et al. (2004) The human plasma proteome: a nonredundant list developed by combination of four separate sources. Mol. Cell Proteomics 3 311-26 PubMed GONUTS page

[PMID:14696115-18] Wakita, T et al. (2004) Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma. Int. J. Cancer 108 516-23 PubMed GONUTS page

[PMID:11722589-19] Jerabek, I et al. (2001) Binding of retinoic acid by the inhibitory serpin protein C inhibitor. Eur. J. Biochem. 268 5989-96 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:11120760-21] 21.0 ^21.1 Uhrin, P et al. (2000) Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. J. Clin. Invest. 106 1531-9 PubMed GONUTS page

[PMID:8796266-22] Geiger, M et al. (1996) Protein C inhibitor (PCI). Immunopharmacology 32 53-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

HUMAN:IPSP

Contents

Annotations

Notes

References

a

b

c

e

f

g

h

l

m

n

p

r

s

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools