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HUMAN:IL37

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IL37 (synonyms: FIL1Z, IL1F7, IL1H4, IL1RP1)
Protein Name(s) Interleukin-37

FIL1 zeta IL-1X Interleukin-1 family member 7 IL-1F7 Interleukin-1 homolog 4 IL-1H IL-1H4 Interleukin-1 zeta IL-1 zeta Interleukin-1-related protein IL-1RP1 Interleukin-23 IL-37

External Links
UniProt Q9NZH6
EMBL AF200496
AF167368
AF251118
AF251119
AF251120
AF201832
AY071840
AY071841
AY973625
AB451333
AB451478
AC079753
CH471217
BC020637
CCDS CCDS2103.1
CCDS2104.1
CCDS2105.1
CCDS2106.1
CCDS2107.1
RefSeq NP_055254.2
NP_775294.1
NP_775295.1
NP_775296.1
NP_775297.1
UniGene Hs.166371
ProteinModelPortal Q9NZH6
SMR Q9NZH6
BioGrid 118054
IntAct Q9NZH6
MINT MINT-1208512
STRING 9606.ENSP00000263326
DMDM 25008593
PaxDb Q9NZH6
PRIDE Q9NZH6
DNASU 27178
Ensembl ENST00000263326
ENST00000311328
ENST00000349806
ENST00000352179
ENST00000353225
GeneID 27178
KEGG hsa:27178
UCSC uc002tij.3
uc002tik.3
uc002til.3
uc002tim.3
uc002tin.3
CTD 27178
GeneCards GC02P113672
HGNC HGNC:15563
HPA HPA054371
HPA057950
MIM 605510
neXtProt NX_Q9NZH6
PharmGKB PA38390
eggNOG NOG78218
GeneTree ENSGT00530000062899
HOVERGEN HBG052101
InParanoid Q9NZH6
KO K05485
OMA RKHTEFS
OrthoDB EOG7RRF8N
PhylomeDB Q9NZH6
TreeFam TF300203
GeneWiki IL1F7
GenomeRNAi 27178
NextBio 49992
PMAP-CutDB Q9NZH6
PRO PR:Q9NZH6
Proteomes UP000005640
Bgee Q9NZH6
CleanEx HS_IL1F7
Genevestigator Q9NZH6
GO GO:0005829
GO:0005576
GO:0005615
GO:0005634
GO:0005149
GO:0006955
GO:0006954
InterPro IPR008996
IPR000975
IPR003297
IPR027169
PANTHER PTHR10078:SF9
Pfam PF00340
PRINTS PR00264
PR01360
SUPFAM SSF50353

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006955

immune response

PMID:10744718[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:10625660[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10625660[2]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

PMID:10744718[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071222

cellular response to lipopolysaccharide

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000008572
RGD:2891

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96543
PANTHER:PTN000008572
RGD:2891

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96543
PANTHER:PTN000008572
RGD:2891

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859324
MGI:MGI:1916927
MGI:MGI:2449929
MGI:MGI:96543
PANTHER:PTN000008572
RGD:2891

P

Seeded From UniProt

complete

involved_in

GO:0030593

neutrophil chemotaxis

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96543
PANTHER:PTN000008572

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000008572
UniProtKB:P01584

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002560666
UniProtKB:Q9NZH6

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1859324
MGI:MGI:1916927
MGI:MGI:2449929
MGI:MGI:96543
PANTHER:PTN000008572
RGD:2891
RGD:621159
UniProtKB:P01584
UniProtKB:P18510

C

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000008572
RGD:621159
UniProtKB:P18510

F

Seeded From UniProt

complete

part_of

GO:0043231

intracellular membrane-bounded organelle

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

involved_in

GO:0010469

regulation of signaling receptor activity

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0005125

P

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975

F

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003297

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975

C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975

P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000975

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

PMID:10744718[1]
Reactome:R-HSA-9008694
Reactome:R-HSA-9008587
Reactome:R-HSA-9008577
Reactome:R-HSA-8848335

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

enables

GO:0005149

interleukin-1 receptor binding

PMID:10625660[2]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071345

cellular response to cytokine stimulus

Reactome:R-HSA-9008059

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-9012689
Reactome:R-HSA-9012556
Reactome:R-HSA-9012542
Reactome:R-HSA-9009910
Reactome:R-HSA-9008928
Reactome:R-HSA-9008696
Reactome:R-HSA-9008694
Reactome:R-HSA-9008692

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-9008696

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005125

cytokine activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0202

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0091

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Kumar, S et al. (2000) Identification and initial characterization of four novel members of the interleukin-1 family. J. Biol. Chem. 275 10308-14 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Smith, DE et al. (2000) Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 275 1169-75 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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