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HUMAN:IL23R
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL23R | |
| Protein Name(s) | Interleukin-23 receptor
IL-23 receptor IL-23R | |
| External Links | ||
| UniProt | Q5VWK5 | |
| EMBL | AF461422 AY937250 AY937251 AY937252 AY937253 AY937254 AY937255 AL389925 AL109843 AL389925 AL109843 AL109843 AL389925 AL109843 AL389925 BC016829 BC040720 | |
| CCDS | CCDS637.1 | |
| RefSeq | NP_653302.2 XP_005270573.1 XP_005270574.1 | |
| UniGene | Hs.677426 | |
| ProteinModelPortal | Q5VWK5 | |
| SMR | Q5VWK5 | |
| BioGrid | 127199 | |
| PhosphoSite | Q5VWK5 | |
| DMDM | 311033431 | |
| PaxDb | Q5VWK5 | |
| PRIDE | Q5VWK5 | |
| DNASU | 149233 | |
| Ensembl | ENST00000347310 ENST00000395227 | |
| GeneID | 149233 | |
| KEGG | hsa:149233 | |
| UCSC | uc001ddo.3 uc001dds.3 uc001ddt.3 uc010opk.2 uc010opw.2 | |
| CTD | 149233 | |
| GeneCards | GC01P067632 | |
| H-InvDB | HIX0023553 | |
| HGNC | HGNC:19100 | |
| HPA | HPA056427 | |
| MIM | 605606 607562 612261 | |
| neXtProt | NX_Q5VWK5 | |
| Orphanet | 117 206 771 | |
| PharmGKB | PA134935109 | |
| eggNOG | NOG41959 | |
| GeneTree | ENSGT00530000064198 | |
| HOVERGEN | HBG081787 | |
| InParanoid | Q5VWK5 | |
| KO | K05065 | |
| OMA | DEFVSCL | |
| OrthoDB | EOG7C2R0N | |
| PhylomeDB | Q5VWK5 | |
| TreeFam | TF335930 | |
| SignaLink | Q5VWK5 | |
| GeneWiki | Interleukin-23_receptor | |
| GenomeRNAi | 149233 | |
| NextBio | 86105 | |
| PRO | PR:Q5VWK5 | |
| Proteomes | UP000005640 | |
| Bgee | Q5VWK5 | |
| ExpressionAtlas | Q5VWK5 | |
| Genevestigator | Q5VWK5 | |
| GO | GO:0072536 GO:0043235 GO:0050829 GO:0006954 GO:0038155 GO:0032693 GO:0042104 GO:0010535 GO:0002230 GO:0032725 GO:0032729 GO:0032735 GO:0032740 GO:0043382 GO:0032819 GO:0051135 GO:0045672 GO:0001916 GO:0042102 GO:0002827 GO:2000330 GO:2000318 GO:0042517 GO:0042520 GO:0042523 GO:0042510 GO:0034341 GO:0032496 | |
| Gene3D | 2.60.40.10 | |
| InterPro | IPR003961 IPR013783 | |
| SMART | SM00060 | |
| SUPFAM | SSF49265 | |
| PROSITE | PS50853 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:2000330 |
positive regulation of T-helper 17 cell lineage commitment |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:2000318 |
positive regulation of T-helper 17 type immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072536 |
interleukin-23 receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051135 |
positive regulation of NK T cell activation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050829 |
defense response to Gram-negative bacterium |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045672 |
positive regulation of osteoclast differentiation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0043382 |
positive regulation of memory T cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042509 |
regulation of tyrosine phosphorylation of STAT protein |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042104 |
positive regulation of activated T cell proliferation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0042102 |
positive regulation of T cell proliferation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0042020 |
interleukin-23 receptor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
contributes_to |
GO:0042019 |
interleukin-23 binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034341 |
response to interferon-gamma |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032819 |
positive regulation of natural killer cell proliferation |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032740 |
positive regulation of interleukin-17 production |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032735 |
positive regulation of interleukin-12 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032725 |
positive regulation of granulocyte macrophage colony-stimulating factor production |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0032693 |
negative regulation of interleukin-10 production |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010536 |
positive regulation of activation of Janus kinase activity |
ECO:0000305 |
curator inference used in manual assertion |
GO:0042019 |
P |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005143 |
interleukin-12 receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002827 |
positive regulation of T-helper 1 type immune response |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002827 |
positive regulation of T-helper 1 type immune response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002230 |
positive regulation of defense response to virus by host |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001916 |
positive regulation of T cell mediated cytotoxicity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0072536 |
interleukin-23 receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000547892 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0042019 |
interleukin-23 binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000547892 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0019955 |
cytokine binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:104579 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0005143 |
interleukin-12 receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000547892 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004896 |
cytokine receptor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN002745476 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0043235 |
receptor complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032729 |
positive regulation of interferon-gamma production |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0038155 |
interleukin-23-mediated signaling pathway |
Reactome:R-HSA-9020933 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005886 |
plasma membrane |
Reactome:R-HSA-8952823 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005886 |
plasma membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Parham, C et al. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168 5699-708 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 van de Wetering, D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21 145-53 PubMed GONUTS page
- ↑ 3.0 3.1 Smits, HH et al. (2004) Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur. J. Immunol. 34 1371-80 PubMed GONUTS page
- ↑ 4.0 4.1 Yago, T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 9 R96 PubMed GONUTS page
- ↑ 5.0 5.1 Oppmann, B et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13 715-25 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 van de Wetering, D et al. (2009) Salmonella induced IL-23 and IL-1beta allow for IL-12 production by monocytes and Mphi1 through induction of IFN-gamma in CD56 NK/NK-like T cells. PLoS ONE 4 e8396 PubMed GONUTS page
- ↑ Vaknin-Dembinsky, A et al. (2006) IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol. 176 7768-74 PubMed GONUTS page
- ↑ Pirhonen, J et al. (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J. Immunol. 169 5673-8 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 9.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Ghai, R et al. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc. Natl. Acad. Sci. U.S.A. 110 E643-52 PubMed GONUTS page
c
i
- GO:0002376 ! immune system process
- GO:0006954 ! inflammatory response
- GO:0045087 ! innate immune response
- GO:0016021 ! integral component of membrane
- GO:0005143 ! interleukin-12 receptor binding
- GO:0042019 ! interleukin-23 binding
- GO:0042020 ! interleukin-23 receptor activity
- GO:0072536 ! interleukin-23 receptor complex
- GO:0038155 ! interleukin-23-mediated signaling pathway
p
- GO:0005886 ! plasma membrane
- GO:0051135 ! positive regulation of NK T cell activation
- GO:0042104 ! positive regulation of activated T cell proliferation
- GO:0042102 ! positive regulation of T cell proliferation
- GO:0043382 ! positive regulation of memory T cell differentiation
- GO:0045672 ! positive regulation of osteoclast differentiation
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0032735 ! positive regulation of interleukin-12 production
- GO:0032729 ! positive regulation of type II interferon production
- GO:0032819 ! positive regulation of natural killer cell proliferation
- GO:0032740 ! positive regulation of interleukin-17 production
- GO:2000318 ! positive regulation of T-helper 17 type immune response
- GO:0001916 ! positive regulation of T cell mediated cytotoxicity
- GO:0002230 ! positive regulation of defense response to virus by host
- GO:0002827 ! positive regulation of T-helper 1 type immune response
- GO:0032725 ! positive regulation of granulocyte macrophage colony-stimulating factor production
- GO:2000330 ! positive regulation of T-helper 17 cell lineage commitment
- Primates
r
