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HUMAN:IL21R

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IL21R (synonyms: NILR)
Protein Name(s) Interleukin-21 receptor

IL-21 receptor IL-21R Novel interleukin receptor

External Links
UniProt Q9HBE5
EMBL AF254067
AF269133
AY358826
AY064474
AK292663
CH471145
CH471145
CH471145
BC004348
BC007946
CCDS CCDS10630.1
RefSeq NP_068570.1
NP_851564.1
NP_851565.4
UniGene Hs.210546
PDB 3TGX
PDBsum 3TGX
ProteinModelPortal Q9HBE5
SMR Q9HBE5
BioGrid 119095
STRING 9606.ENSP00000338010
DMDM 20454997
MaxQB Q9HBE5
PaxDb Q9HBE5
PRIDE Q9HBE5
DNASU 50615
Ensembl ENST00000337929
ENST00000395754
ENST00000564089
GeneID 50615
KEGG hsa:50615
UCSC uc002doq.2
CTD 50615
GeneCards GC16P027413
H-InvDB HIX0012914
HGNC HGNC:6006
HPA HPA042296
MIM 605383
615207
neXtProt NX_Q9HBE5
Orphanet 357329
PharmGKB PA29821
eggNOG NOG40447
GeneTree ENSGT00510000048783
HOGENOM HOG000013192
HOVERGEN HBG052105
InParanoid Q9HBE5
KO K05075
OMA RDRPYGL
OrthoDB EOG767398
PhylomeDB Q9HBE5
TreeFam TF337874
SignaLink Q9HBE5
GeneWiki Interleukin-21_receptor
GenomeRNAi 50615
NextBio 53120
PRO PR:Q9HBE5
Proteomes UP000005640
Bgee Q9HBE5
CleanEx HS_IL21R
Genevestigator Q9HBE5
GO GO:0016021
GO:0001532
GO:0038114
GO:0030101
Gene3D 2.60.40.10
InterPro IPR003961
IPR003531
IPR013783
SMART SM00060
SUPFAM SSF49265
PROSITE PS50853
PS01355

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0030101

natural killer cell activation

PMID:11081504[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:11081504[1]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0001532

interleukin-21 receptor activity

PMID:11081504[1]

ECO:0000303

author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

PMID:11016959[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004888

transmembrane signaling receptor activity

PMID:11016959[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9JHX3
ensembl:ENSMUSP00000033000

F

Seeded From UniProt

complete

enables

GO:0004896

cytokine receptor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003531

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003531

C

Seeded From UniProt

complete

involved_in

GO:0038114

interleukin-21-mediated signaling pathway

Reactome:R-HSA-9020958

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-9006873
Reactome:R-HSA-9006870
Reactome:R-HSA-9006850
Reactome:R-HSA-9006844
Reactome:R-HSA-9005980

ECO:0000304

author statement supported by traceable reference used in manual assertion





C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Parrish-Novak, J et al. (2000) Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408 57-63 PubMed GONUTS page
  2. 2.0 2.1 Ozaki, K et al. (2000) Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain. Proc. Natl. Acad. Sci. U.S.A. 97 11439-44 PubMed GONUTS page