HUMAN:IL2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IL2
Protein Name(s)	Interleukin-2 IL-2 T-cell growth factor TCGF
External Links
UniProt	P60568
EMBL	X00695 V00564 X01586 J00264 K02056 S77834 S82692 AF359939 BC066255 BC066257 BC070338 M33199 M13879 M22005
CCDS	CCDS3726.1
PIR	A01849
RefSeq	NP_000577.2
UniGene	Hs.89679
PDB	1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1
PDBsum	1ILM 1ILN 1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1
ProteinModelPortal	P60568
SMR	P60568
BioGrid	109773
DIP	DIP-475N
MINT	MINT-1522299
STRING	9606.ENSP00000226730
BindingDB	P60568
ChEMBL	CHEMBL5880
DrugBank	DB00852
PhosphoSite	P60568
UniCarbKB	P60568
DMDM	45593462
PaxDb	P60568
PRIDE	P60568
DNASU	3558
Ensembl	ENST00000226730
GeneID	3558
KEGG	hsa:3558
UCSC	uc003ier.3
CTD	3558
GeneCards	GC04M123372
HGNC	HGNC:6001
HPA	CAB010310
MIM	147680
neXtProt	NX_P60568
PharmGKB	PA195
eggNOG	NOG41211
HOVERGEN	HBG007496
InParanoid	P60568
KO	K05429
OMA	LMSNINV
OrthoDB	EOG72RN13
PhylomeDB	P60568
TreeFam	TF338200
Reactome	REACT_1695 REACT_19290 REACT_23891 REACT_27283
SignaLink	P60568
ChiTaRS	IL2
EvolutionaryTrace	P60568
GeneWiki	Interleukin_2
GenomeRNAi	3558
NextBio	13896
PRO	PR:P60568
Proteomes	UP000005640
Bgee	P60568
CleanEx	HS_IL2
ExpressionAtlas	P60568
Genevestigator	P60568
GO	GO:0005576 GO:0005615 GO:0030246 GO:0005125 GO:0043208 GO:0008083 GO:0005134 GO:0019209 GO:0007155 GO:0007267 GO:0097192 GO:0006955 GO:0030101 GO:0043066 GO:0002903 GO:0045822 GO:0050728 GO:0050672 GO:0001933 GO:0042104 GO:0030890 GO:0030307 GO:0008284 GO:0007204 GO:0060999 GO:0051024 GO:0050729 GO:0032729 GO:0032740 GO:0048304 GO:0045591 GO:0034105 GO:0045944 GO:0042523 GO:0007205 GO:0046013 GO:0030217
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000779
PANTHER	PTHR11443
Pfam	PF00715
PRINTS	PR00265
ProDom	PD003649
SMART	SM00189
SUPFAM	SSF47266
PROSITE	PS00424

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0042102	positive regulation of T cell proliferation	PMID:24416451^[1]	ECO:0000314			P	Figure 1 shows initial reduction of CD4 T-cells when IL-2 is inhibited	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	PMID:16204630^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:16482511^[3]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:19088061^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0034105	positive regulation of tissue remodeling	PMID:16482511^[3]	ECO:0000305	curator inference used in manual assertion	GO:0032740	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	PMID:16482511^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:1830926^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:10072077^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:9184696^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:8262055^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1830926^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10072077^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0002903	negative regulation of B cell apoptotic process	PMID:9184696^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0007204	C	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P	Seeded From UniProt	complete
involved_in	GO:0033674	positive regulation of kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019209	P	Seeded From UniProt	complete
involved_in	GO:2000320	negative regulation of T-helper 17 cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0051024	positive regulation of immunoglobulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0050728	negative regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0050672	negative regulation of lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0048304	positive regulation of isotype switching to IgG isotypes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0046013	regulation of T cell homeostatic proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	C	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P04351 ensembl:ENSMUSP00000029275	F	Seeded From UniProt	complete
involved_in	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0045822	negative regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0045591	positive regulation of regulatory T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
enables	GO:0043208	glycosphingolipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	F	Seeded From UniProt	complete
involved_in	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
enables	GO:0031851	kappa-type opioid receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	F	Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	F	Seeded From UniProt	complete
involved_in	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	C	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P17108 ensembl:ENSRNOP00000023327	P	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	F	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	C	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	F	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030101	natural killer cell activation	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019209	kinase activator activity	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0007267	cell-cell signaling	PMID:8476561^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007155	cell adhesion	PMID:10929056^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:2342538^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:6608729^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:3925347^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045589	regulation of regulatory T cell differentiation	Reactome:R-HSA-8877330	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-919404 Reactome:R-HSA-913424 Reactome:R-HSA-913374 Reactome:R-HSA-912527 Reactome:R-HSA-8877345 Reactome:R-HSA-5672965 Reactome:R-HSA-508292 Reactome:R-HSA-508282 Reactome:R-HSA-508247 Reactome:R-HSA-453111 Reactome:R-HSA-453104 Reactome:R-HSA-452122 Reactome:R-HSA-452108 Reactome:R-HSA-452100 Reactome:R-HSA-452097 Reactome:R-HSA-452091 Reactome:R-HSA-451942 Reactome:R-HSA-450063 Reactome:R-HSA-450054 Reactome:R-HSA-450027	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C	Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F	Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Khattar, M et al. (2014) Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions. PLoS ONE 9 e85882 PubMed GONUTS page
↑ Feng, Y et al. (2005) HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes? J. Leukoc. Biol. 78 1136-41 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page
↑ van de Wetering, D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21 145-53 PubMed GONUTS page
↑ ^5.0 ^5.1 Schorle, H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352 621-4 PubMed GONUTS page
↑ ^6.0 ^6.1 Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page
↑ ^7.0 ^7.1 Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ Zurawski, SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J. 12 5113-9 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Minami, Y et al. (1993) The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11 245-68 PubMed GONUTS page
↑ Ariel, A et al. (2000) Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators. Immunology 100 345-51 PubMed GONUTS page
↑ Weinberg, K & Parkman, R (1990) Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N. Engl. J. Med. 322 1718-23 PubMed GONUTS page
↑ Holbrook, NJ et al. (1984) T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc. Natl. Acad. Sci. U.S.A. 81 1634-8 PubMed GONUTS page
↑ Lowenthal, JW et al. () Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature 315 669-72 PubMed GONUTS page

[PMID:24416451-1] Khattar, M et al. (2014) Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions. PLoS ONE 9 e85882 PubMed GONUTS page

[PMID:16204630-2] Feng, Y et al. (2005) HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes? J. Leukoc. Biol. 78 1136-41 PubMed GONUTS page

[PMID:16482511-3] 3.0 ^3.1 ^3.2 Hoeve, MA et al. (2006) Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells. Eur. J. Immunol. 36 661-70 PubMed GONUTS page

[PMID:19088061-4] van de Wetering, D et al. (2009) IL-23 modulates CD56+/CD3- NK cell and CD56+/CD3+ NK-like T cell function differentially from IL-12. Int. Immunol. 21 145-53 PubMed GONUTS page

[PMID:1830926-5] 5.0 ^5.1 Schorle, H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352 621-4 PubMed GONUTS page

[PMID:10072077-6] 6.0 ^6.1 Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page

[PMID:9184696-7] 7.0 ^7.1 Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page

[PMID:8262055-8] Zurawski, SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J. 12 5113-9 PubMed GONUTS page

[PMID:8476561-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Minami, Y et al. (1993) The IL-2 receptor complex: its structure, function, and target genes. Annu. Rev. Immunol. 11 245-68 PubMed GONUTS page

[PMID:10929056-10] Ariel, A et al. (2000) Induction of interactions between CD44 and hyaluronic acid by a short exposure of human T cells to diverse pro-inflammatory mediators. Immunology 100 345-51 PubMed GONUTS page

[PMID:2342538-11] Weinberg, K & Parkman, R (1990) Severe combined immunodeficiency due to a specific defect in the production of interleukin-2. N. Engl. J. Med. 322 1718-23 PubMed GONUTS page

[PMID:6608729-12] Holbrook, NJ et al. (1984) T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc. Natl. Acad. Sci. U.S.A. 81 1634-8 PubMed GONUTS page

[PMID:3925347-13] Lowenthal, JW et al. () Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes. Nature 315 669-72 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

HUMAN:IL2

Contents

Annotations

Notes

References

a

c

e

g

h

i

k

l

m

n

o

p

r

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools