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HUMAN:IL17
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL17A (synonyms: CTLA8, IL17) | |
| Protein Name(s) | Interleukin-17A
IL-17 IL-17A Cytotoxic T-lymphocyte-associated antigen 8 CTLA-8 | |
| External Links | ||
| UniProt | Q16552 | |
| EMBL | Z58820 U32659 AY460616 AL391221 CH471081 BC066251 BC066252 BC067503 BC067504 BC067505 | |
| CCDS | CCDS4937.1 | |
| RefSeq | NP_002181.1 | |
| UniGene | Hs.41724 | |
| PDB | 2VXS 4HR9 4HSA | |
| PDBsum | 2VXS 4HR9 4HSA | |
| ProteinModelPortal | Q16552 | |
| SMR | Q16552 | |
| BioGrid | 109818 | |
| DIP | DIP-6014N | |
| STRING | 9606.ENSP00000344192 | |
| PhosphoSite | Q16552 | |
| DMDM | 2498481 | |
| PaxDb | Q16552 | |
| PRIDE | Q16552 | |
| DNASU | 3605 | |
| Ensembl | ENST00000340057 | |
| GeneID | 3605 | |
| KEGG | hsa:3605 | |
| UCSC | uc003pak.1 | |
| CTD | 3605 | |
| GeneCards | GC06P052051 | |
| HGNC | HGNC:5981 | |
| HPA | HPA052258 | |
| MIM | 603149 | |
| neXtProt | NX_Q16552 | |
| PharmGKB | PA29794 | |
| eggNOG | NOG42989 | |
| GeneTree | ENSGT00730000110824 | |
| HOGENOM | HOG000064520 | |
| HOVERGEN | HBG006143 | |
| InParanoid | Q16552 | |
| KO | K05489 | |
| OMA | HMNSVPI | |
| OrthoDB | EOG70089V | |
| PhylomeDB | Q16552 | |
| TreeFam | TF314701 | |
| EvolutionaryTrace | Q16552 | |
| GeneWiki | IL17A | |
| GenomeRNAi | 3605 | |
| NextBio | 14089 | |
| PRO | PR:Q16552 | |
| Proteomes | UP000005640 | |
| Bgee | Q16552 | |
| CleanEx | HS_IL17A | |
| ExpressionAtlas | Q16552 | |
| Genevestigator | Q16552 | |
| GO | GO:0009897 GO:0005615 GO:0005125 GO:0006915 GO:0008219 GO:0007267 GO:0071347 GO:0072537 GO:0006955 GO:0006954 GO:1900017 GO:0032747 GO:0045672 GO:0045944 GO:0006486 | |
| Gene3D | 2.10.90.10 | |
| InterPro | IPR029034 IPR020440 IPR010345 | |
| PANTHER | PTHR21295 | |
| Pfam | PF06083 | |
| PRINTS | PR01932 | |
| SUPFAM | SSF57501 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0072537 |
fibroblast activation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045672 |
positive regulation of osteoclast differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0032747 |
positive regulation of interleukin-23 production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:2000778 |
positive regulation of interleukin-6 secretion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:1900017 |
positive regulation of cytokine production involved in inflammatory response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0097530 |
granulocyte migration |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0071347 |
cellular response to interleukin-1 |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0050832 |
defense response to fungus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0009897 |
external side of plasma membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q62386 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008219 |
cell death |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007267 |
cell-cell signaling |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006955 |
immune response |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097400 |
interleukin-17-mediated signaling pathway |
Reactome:R-HSA-448424 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-6785807 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-6789615 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhu, L et al. (2011) IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-κB versus JNK/AP-1 pathways. Mol. Immunol. 48 647-56 PubMed GONUTS page
- ↑ Yago, T et al. (2007) IL-23 induces human osteoclastogenesis via IL-17 in vitro, and anti-IL-23 antibody attenuates collagen-induced arthritis in rats. Arthritis Res. Ther. 9 R96 PubMed GONUTS page
- ↑ Liang, SC et al. (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203 2271-9 PubMed GONUTS page
- ↑ Rouvier, E et al. (1993) CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150 5445-56 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 Yao, Z et al. (1995) Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155 5483-6 PubMed GONUTS page
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- GO:2000778 ! positive regulation of interleukin-6 secretion
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0032747 ! positive regulation of interleukin-23 production
- GO:1900017 ! positive regulation of cytokine production involved in inflammatory response
- GO:0045672 ! positive regulation of osteoclast differentiation
- Primates
