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HUMAN:IFIT1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFIT1 (synonyms: G10P1, IFI56, IFNAI1, ISG56)
Protein Name(s) Interferon-induced protein with tetratricopeptide repeats 1

IFIT-1 Interferon-induced 56 kDa protein IFI-56K P56

External Links
UniProt P09914
EMBL X03557
BT006667
AK092813
AK314588
AL353146
CH471066
CH471066
CH471066
BC007091
X06559
CCDS CCDS31243.1
CCDS59220.1
PIR A25407
RefSeq NP_001257857.1
NP_001257858.1
NP_001257859.1
NP_001539.3
UniGene Hs.20315
PDB 4HOU
PDBsum 4HOU
ProteinModelPortal P09914
SMR P09914
BioGrid 109659
DIP DIP-37898N
IntAct P09914
MINT MINT-153827
STRING 9606.ENSP00000360869
PhosphoSite P09914
DMDM 116242522
MaxQB P09914
PaxDb P09914
PRIDE P09914
DNASU 3434
Ensembl ENST00000371804
ENST00000546318
GeneID 3434
KEGG hsa:3434
UCSC uc001kgi.4
CTD 3434
GeneCards GC10P091142
HGNC HGNC:5407
HPA CAB045980
HPA055380
MIM 147690
neXtProt NX_P09914
PharmGKB PA29648
eggNOG NOG311487
GeneTree ENSGT00390000013876
HOGENOM HOG000001558
HOVERGEN HBG066330
InParanoid P09914
KO K14217
OMA MECPEID
OrthoDB EOG71K62V
PhylomeDB P09914
TreeFam TF342671
Reactome REACT_115831
REACT_25162
GeneWiki IFIT1
GenomeRNAi 3434
NextBio 13540
PRO PR:P09914
Proteomes UP000005640
Bgee P09914
CleanEx HS_IFIT1
Genevestigator P09914
GO GO:0005737
GO:0005829
GO:0003723
GO:0071360
GO:0071357
GO:0019221
GO:0051607
GO:0019060
GO:0050689
GO:0051097
GO:0032091
GO:0045071
GO:0045070
GO:0009615
GO:0060337
Gene3D 1.25.40.10
InterPro IPR024121
IPR013026
IPR011990
IPR001440
IPR013105
IPR019734
PANTHER PTHR10271:SF15
Pfam PF00515
PF07719
SMART SM00028
PROSITE PS50005
PS50293

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0051117

ATPase binding

PMID:19008854[1]

ECO:0000021

UniProtKB:P06789


F

Figure 1B, 1C, 1D, 3B, 3C and 3D. Co-immunoprecipitation assays and immunofluorescence confirm the binding of ATPase HPV18 E1 to the TPR2 domain of P56 (IFIT1) protein.

complete

GO:0051117

ATPase binding

PMID:19008854[1]

ECO:0000021

UniProtKB:P04014


F

Figure S1 and S2. Co-immunoprecipitation assays confirm the binding of ATPase HPV11 E1 to the TPR2 domain of P56 (IFIT1) protein.

complete

GO:0005737

cytoplasm

PMID:19008854[1]

ECO:0000314

C

Figure 1E, panel 2 (left) and 5F (left). Immunofluorescence confirms the location of P56 (IFIT1) in the cytoplasm.

complete

GO:0016482

cytoplasmic transport

PMID:19008854[1]

ECO:0000314

P

Figure 1B, 1C, 1D and 1E panel 2 (middle). Co-immunoprecipitation and pull-down assays were corroborated by immunofluorescence results confirming cytoplasmic translocation of E1 on its interaction with P56 (IFIT1).

complete

GO:0045071

negative regulation of viral genome replication

PMID:19008854[1]

ECO:0000315

P

Figure 5B and 5D. Ablation of P56 (IFIT1) expression by siRNA or shRNAi for P56 substantially alleviating the HPV DNA replication inhibition.

complete

GO:0051097

negative regulation of helicase activity

PMID:19008854[1]

ECO:0000314

P

Figure 7A and 7B confirm that P56 (IFIT1) inhibits the helicase activity of E1.

complete

involved_in

GO:0071360

cellular response to exogenous dsRNA

PMID:19008854[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071357

cellular response to type I interferon

PMID:19008854[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051097

negative regulation of helicase activity

PMID:19008854[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:19008854[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045070

positive regulation of viral genome replication

PMID:19416887[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

PMID:19416887[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019060

intracellular transport of viral protein in host cell

PMID:19008854[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:19416887[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19008854[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21976647[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:21642987[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21642987[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

PMID:21642987[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000814563
UniProtKB:E7FBH4
UniProtKB:Q13325
ZFIN:ZDB-GENE-131120-20

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[5]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000814563
UniProtKB:O14879
UniProtKB:P09914

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043657

host cell

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019060

C

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024121

P

Seeded From UniProt

complete

involved_in

GO:0050688

regulation of defense response to virus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024121

P

Seeded From UniProt

complete

involved_in

GO:0071357

cellular response to type I interferon

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024121

P

Seeded From UniProt

complete

involved_in

GO:0071360

cellular response to exogenous dsRNA

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR024121

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-1678841
Reactome:R-HSA-1169406
Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.00 1.01 1.02 1.03 1.04 1.05 1.06 1.07 1.08 1.09 1.10 1.11 Terenzi, F et al. (2008) Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1. EMBO J. 27 3311-21 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Li, Y et al. (2009) ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc. Natl. Acad. Sci. U.S.A. 106 7945-50 PubMed GONUTS page
  3. ↑ Raychoudhuri, A et al. (2011) ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 85 12881-9 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Pichlmair, A et al. (2011) IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nat. Immunol. 12 624-30 PubMed GONUTS page
  5. ↑ 5.0 5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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