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HUMAN:IBTK

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IBTK (synonyms: BTKI, KIAA1417)
Protein Name(s) Inhibitor of Bruton tyrosine kinase

IBtk

External Links
UniProt Q9P2D0
EMBL DQ005633
DQ005634
DQ005635
AB037838
AL050333
AL050333
BC027490
BC038244
BC042171
BC113696
BC113698
AL050018
AF235049
CCDS CCDS34490.1
PIR T08705
RefSeq NP_001287835.1
NP_056340.2
UniGene Hs.306425
ProteinModelPortal Q9P2D0
SMR Q9P2D0
BioGrid 117474
IntAct Q9P2D0
MINT MINT-215747
PhosphoSite Q9P2D0
DMDM 134034141
MaxQB Q9P2D0
PaxDb Q9P2D0
PRIDE Q9P2D0
DNASU 25998
Ensembl ENST00000306270
GeneID 25998
KEGG hsa:25998
UCSC uc003pjl.1
uc003pjm.2
CTD 25998
GeneCards GC06M082879
HGNC HGNC:17853
HPA HPA023826
MIM 606457
neXtProt NX_Q9P2D0
PharmGKB PA134898277
eggNOG COG5184
GeneTree ENSGT00770000120483
HOVERGEN HBG081779
InParanoid Q9P2D0
OMA VSALHHK
OrthoDB EOG7K6PT6
PhylomeDB Q9P2D0
TreeFam TF323747
ChiTaRS IBTK
GenomeRNAi 25998
NextBio 47714
PRO PR:Q9P2D0
Proteomes UP000005640
Bgee Q9P2D0
ExpressionAtlas Q9P2D0
Genevestigator Q9P2D0
GO GO:0005737
GO:0016020
GO:0005634
GO:0019901
GO:0030292
GO:0001933
GO:0061099
GO:0051209
Gene3D 1.25.40.20
2.130.10.30
InterPro IPR002110
IPR020683
IPR000210
IPR011333
IPR013069
IPR009091
IPR000408
Pfam PF12796
PF00651
PF00415
SMART SM00248
SM00225
SUPFAM SSF48403
SSF50985
SSF54695
PROSITE PS50297
PS50088
PS50097
PS50012

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0051209

release of sequestered calcium ion into cytosol

PMID:11577348[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0030292

protein tyrosine kinase inhibitor activity

PMID:11577348[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

PMID:11577348[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11577348[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0001933

negative regulation of protein phosphorylation

PMID:11577348[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0061099

negative regulation of protein tyrosine kinase activity

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0030292

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Liu, W et al. (2001) Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein. Nat. Immunol. 2 939-46 PubMed GONUTS page