HUMAN:HXK4

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GCK
Protein Name(s)	Glucokinase Hexokinase type IV HK IV Hexokinase-4 HK4 Hexokinase-D
External Links
UniProt	P35557
EMBL	M88011 M69051 M90298 M90298 M90299 AF041022 AF041012 AF041015 AF041016 AF041017 AF041018 AF041019 AF041020 AF041021 AF041022 AF041013 AF041015 AF041016 AF041017 AF041018 AF041019 AF041020 AF041021 AF041022 AF041014 AF041015 AF041016 AF041017 AF041018 AF041019 AF041020 AF041021 AK122876 CH236960 CH236960 CH471128 CH471128 BC001890
CCDS	CCDS5479.1 CCDS5480.1 CCDS5481.1
PIR	A46157 B46157 C46157
RefSeq	NP_000153.1 NP_277042.1 NP_277043.1
UniGene	Hs.1270
PDB	1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH
PDBsum	1GLK 1V4S 1V4T 3A0I 3F9M 3FGU 3FR0 3GOI 3H1V 3ID8 3IDH 3IMX 3QIC 3S41 3VEV 3VEY 3VF6 4DCH 4DHY 4ISE 4ISF 4ISG 4IWV 4IXC 4L3Q 4LC9 4MLE 4MLH 4NO7 4RCH
ProteinModelPortal	P35557
SMR	P35557
BioGrid	108915
IntAct	P35557
STRING	9606.ENSP00000223366
BindingDB	P35557
ChEMBL	CHEMBL3820
GuidetoPHARMACOLOGY	2798
PhosphoSite	P35557
DMDM	547696
PaxDb	P35557
PRIDE	P35557
DNASU	2645
Ensembl	ENST00000345378 ENST00000395796 ENST00000403799 ENST00000616242
GeneID	2645
KEGG	hsa:2645
UCSC	uc003tkj.1 uc003tkk.1 uc003tkl.2
CTD	2645
GeneCards	GC07M044183
GeneReviews	GCK
HGNC	HGNC:4195
HPA	HPA007034 HPA007093
MIM	125851 138079 602485 606391
neXtProt	NX_P35557
Orphanet	79299 552 99885
PharmGKB	PA28610
eggNOG	COG5026
GeneTree	ENSGT00390000017159
HOGENOM	HOG000162670
HOVERGEN	HBG000142
InParanoid	P35557
KO	K12407
OMA	EDHQCEV
PhylomeDB	P35557
TreeFam	TF314238
BioCyc	MetaCyc:HS02935-MONOMER
Reactome	REACT_13819 REACT_212 REACT_6804
SABIO-RK	P35557
ChiTaRS	GCK
EvolutionaryTrace	P35557
GeneWiki	Glucokinase
GenomeRNAi	2645
NextBio	10434
PRO	PR:P35557
Proteomes	UP000005640
Bgee	P35557
CleanEx	HS_GCK
ExpressionAtlas	P35557
Genevestigator	P35557
GO	GO:0005884 GO:0045180 GO:0005829 GO:0005739 GO:0005654 GO:0030141 GO:0043531 GO:0005524 GO:0004340 GO:0005536 GO:0000287 GO:0070509 GO:0005975 GO:0001678 GO:0042149 GO:0032869 GO:0044320 GO:0051594 GO:0031018 GO:0006003 GO:0042593 GO:0006006 GO:0015758 GO:0005978 GO:0006096 GO:0008645 GO:0055088 GO:0006739 GO:0032811 GO:0045721 GO:0007204 GO:0045725 GO:0045821 GO:0032024 GO:0042327 GO:0010827 GO:0006110 GO:0050796 GO:0043266 GO:0019932 GO:0044281 GO:0055085
InterPro	IPR001312 IPR022673 IPR019807 IPR022672
PANTHER	PTHR19443
Pfam	PF00349 PF03727
PRINTS	PR00475
PROSITE	PS00378

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:19146401^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:19146401^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0051156	glucose 6-phosphate metabolic process	PMID:18322640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:18322640^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:22611063^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:20668700^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044320	cellular response to leptin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17712	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:20668700^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P17712	P	Seeded From UniProt	complete
involved_in	GO:0006110	regulation of glycolytic process	PMID:9570959^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051594	detection of glucose	PMID:12941786^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:8878425^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045721	negative regulation of gluconeogenesis	PMID:8878425^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:8132752^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:8878425^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:8132752^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:16173921^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:12941786^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	PMID:8446612^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16173921^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:12941786^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8446612^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:16173921^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:12941786^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:8446612^[10]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455411 UniProtKB:P35557	P	Seeded From UniProt	complete
enables	GO:0019158	mannokinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c	F	Seeded From UniProt	complete
enables	GO:0008865	fructokinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P93834 UniProtKB:Q4WHC3	F	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000000545 SGD:S000001949 SGD:S000003222	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 RGD:2670 RGD:2796 SGD:S000003222 UniProtKB:C6KT76 UniProtKB:P35557	C	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 MGI:MGI:96103 PANTHER:PTN000455350 PomBase:SPAC24H6.04 PomBase:SPAC4F8.07c RGD:2670 RGD:2796 SGD:S000000545 TAIR:locus:2008031 TAIR:locus:2087590 TAIR:locus:2119931 TAIR:locus:2137564 TAIR:locus:2202410 UniProtKB:P35557 UniProtKB:P93834 UniProtKB:Q4WCS2 UniProtKB:Q4WHC3 UniProtKB:Q5W676 UniProtKB:Q8LQ68	F	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1270854 PANTHER:PTN000455350 RGD:2670	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0070509	calcium ion import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0050796	regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0046835	carbohydrate phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0043266	regulation of potassium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0006739	NADP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	C	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	C	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	F	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	F	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P52792 ensembl:ENSMUSP00000099984	P	Seeded From UniProt	complete
involved_in	GO:0001678	cellular glucose homeostasis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312	P	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	F	Seeded From UniProt	complete
enables	GO:0004396	hexokinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR019807 InterPro:IPR022672 InterPro:IPR022673	F	Seeded From UniProt	complete
enables	GO:0005536	glucose binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR039073	F	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001312 InterPro:IPR022672 InterPro:IPR022673	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019807	P	Seeded From UniProt	complete
enables	GO:0016773	phosphotransferase activity, alcohol group as acceptor	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022672 InterPro:IPR022673	F	Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039073	P	Seeded From UniProt	complete
enables	GO:0004340	glucokinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.1.2	F	Seeded From UniProt	complete
involved_in	GO:0061621	canonical glycolysis	Reactome:R-HSA-70171	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006110	regulation of glycolytic process	Reactome:R-HSA-170822	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-70420 Reactome:R-HSA-5661474 Reactome:R-HSA-170825 Reactome:R-HSA-170824 Reactome:R-HSA-170799 Reactome:R-HSA-170796	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-170825 Reactome:R-HSA-170810 Reactome:R-HSA-170796	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0008152	metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0021	P	Seeded From UniProt	complete
involved_in	GO:0006096	glycolytic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0324	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Pal, P & Miller, BG (2009) Activating mutations in the human glucokinase gene revealed by genetic selection. Biochemistry 48 814-6 PubMed GONUTS page
↑ ^2.0 ^2.1 Estalella, I et al. (2008) Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients. J. Hum. Genet. 53 460-6 PubMed GONUTS page
↑ Beer, NL et al. (2012) Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis. Diabetes Care 35 1482-4 PubMed GONUTS page
↑ ^4.0 ^4.1 Hu, C et al. (2010) Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE 5 e11761 PubMed GONUTS page
↑ Hayward, BE et al. (1998) Organization of the human glucokinase regulator gene GCKR. Genomics 49 137-42 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gloyn, AL et al. (2003) Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes 52 2433-40 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Velho, G et al. (1996) Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J. Clin. Invest. 98 1755-61 PubMed GONUTS page
↑ ^8.0 ^8.1 Byrne, MM et al. (1994) Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J. Clin. Invest. 93 1120-30 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Galán, M et al. (2006) Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability. Biochem. J. 393 389-96 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Gidh-Jain, M et al. (1993) Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc. Natl. Acad. Sci. U.S.A. 90 1932-6 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19146401-1] 1.0 ^1.1 Pal, P & Miller, BG (2009) Activating mutations in the human glucokinase gene revealed by genetic selection. Biochemistry 48 814-6 PubMed GONUTS page

[PMID:18322640-2] 2.0 ^2.1 Estalella, I et al. (2008) Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients. J. Hum. Genet. 53 460-6 PubMed GONUTS page

[PMID:22611063-3] Beer, NL et al. (2012) Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis. Diabetes Care 35 1482-4 PubMed GONUTS page

[PMID:20668700-4] 4.0 ^4.1 Hu, C et al. (2010) Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE 5 e11761 PubMed GONUTS page

[PMID:9570959-5] Hayward, BE et al. (1998) Organization of the human glucokinase regulator gene GCKR. Genomics 49 137-42 PubMed GONUTS page

[PMID:12941786-6] 6.0 ^6.1 ^6.2 ^6.3 Gloyn, AL et al. (2003) Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations. Diabetes 52 2433-40 PubMed GONUTS page

[PMID:8878425-7] 7.0 ^7.1 ^7.2 Velho, G et al. (1996) Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects. J. Clin. Invest. 98 1755-61 PubMed GONUTS page

[PMID:8132752-8] 8.0 ^8.1 Byrne, MM et al. (1994) Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J. Clin. Invest. 93 1120-30 PubMed GONUTS page

[PMID:16173921-9] 9.0 ^9.1 ^9.2 Galán, M et al. (2006) Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability. Biochem. J. 393 389-96 PubMed GONUTS page

[PMID:8446612-10] 10.0 ^10.1 ^10.2 Gidh-Jain, M et al. (1993) Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc. Natl. Acad. Sci. U.S.A. 90 1932-6 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

HUMAN:HXK4

Contents

Annotations

Notes

References

a

c

d

e

f

g

h

i

k

m

n

p

r

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools