HUMAN:HSH2D

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HSH2D (synonyms: ALX)
Protein Name(s)	Hematopoietic SH2 domain-containing protein Hematopoietic SH2 protein Adaptor in lymphocytes of unknown function X
External Links
UniProt	Q96JZ2
EMBL	AY319652 AK027792 AK131222 AC008894 AC020911 CH471106 BC025237
CCDS	CCDS74304.1
PIR	JC7781
RefSeq	NP_001278203.1 NP_116244.1
UniGene	Hs.631617
PDB	2CS0
PDBsum	2CS0
ProteinModelPortal	Q96JZ2
SMR	Q96JZ2
BioGrid	124375
IntAct	Q96JZ2
STRING	9606.ENSP00000253680
PhosphoSite	Q96JZ2
DMDM	74732160
MaxQB	Q96JZ2
PaxDb	Q96JZ2
PRIDE	Q96JZ2
DNASU	84941
Ensembl	ENST00000613986 ENST00000616645
GeneID	84941
KEGG	hsa:84941
UCSC	uc002ndp.4 uc002ndr.3
CTD	84941
GeneCards	GC19P016244
HGNC	HGNC:24920
HPA	HPA036616
MIM	608349
neXtProt	NX_Q96JZ2
PharmGKB	PA134927763
eggNOG	NOG70356
GeneTree	ENSGT00570000079047
HOGENOM	HOG000112961
HOVERGEN	HBG081611
InParanoid	Q96JZ2
OMA	KLWRNLK
OrthoDB	EOG751NG5
PhylomeDB	Q96JZ2
TreeFam	TF336893
SignaLink	Q96JZ2
ChiTaRS	HSH2D
EvolutionaryTrace	Q96JZ2
GenomeRNAi	84941
NextBio	75406
PRO	PR:Q96JZ2
Proteomes	UP000005640
Bgee	Q96JZ2
CleanEx	HS_HSH2D
ExpressionAtlas	Q96JZ2
Genevestigator	Q96JZ2
GO	GO:0005829 GO:0005739 GO:0005634 GO:0002903 GO:0051902 GO:0009967 GO:0042110
Gene3D	3.30.505.10
InterPro	IPR000980
Pfam	PF00017
PRINTS	PR00401
SMART	SM00252
SUPFAM	SSF55550
PROSITE	PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005737	cytoplasm		ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919531 PANTHER:PTN001024419	C		Seeded From UniProt	complete
	GO:0006916	anti-apoptosis	PMID:15569688	ECO:0000314			P		FIG. 1. HSH2 blocks BCR-induced apoptosis in WEHI-231 cells. A, WEHI-231 cells were transduced with retrovirus encoding the empty p-MSCV-puro vector (empty vector) or with virus containing either HSH2:p-MSCV-puro or Bcl-xL:p-MSCV-puro, after which the cells were cultured in the presence of puromycin to select for homogeneous expression of HSH2 or Bcl-xL. Empty vector control (open bar), HSH2- (gray bar), and Bcl-xL- (black bar) expressing WEHI-231 cells (1 � 105 cells/ml) were stimulated with polyclonal anti-IgM F(ab�)2 Ab for 24–48 h, after which cells were harvested and stained with PI to measure DNA content. Cells were analyzed using flow cytometry to quantitate the percentage of the total population that contained sub-G0/G1 levels of DNA at 24 and 48 h. B, quantitation of the percentage of viable cells (ANV�,PI�) at 0, 24, or 48 h after stimulation of empty vector control (●), HSH2 (f), or Bcl-xL (OE) WEHI-231 cells with anti-IgM F(ab�)2 Ab. C, quantitation of the percentage of control (open bar), HSH2- (gray bar), and Bcl-xL- (black bar) expressing WEHI-231 cells that are ANV�,PIlo: characteristic of early apoptotic cells.	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR035047	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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References

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